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- W2083407361 abstract "According to recent data, gramicidin A analogues having positively charged amino acid sequences at the C-termini exhibit two types of channel activity in lipid membranes: classical cation-selective channels and large unselective pores. The induction of unselective pores was shown here to strongly depend on the redox state of the membrane-bathing solution, if the gramicidin analogue contained a cysteine residue in the sequence GSGPKKKRKVC attached to the C-terminus. In particular, the addition of H 2 O 2 led to an increase in the transmembrane current and the loss of cationic selectivity on planar bilayer lipid membranes and an increase in the carboxyfluorescein leakage of liposomes. The effect was observed at high concentration of the peptide while was absent at the single-channel level. It was concluded that oxidation led to possible formation of dimers of the peptide, which promoted the formation of large unselective pores." @default.
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- W2083407361 date "2006-04-01" @default.
- W2083407361 modified "2023-09-24" @default.
- W2083407361 title "Redox-regulated ion channel activity of a cysteine-containing gramicidin A analogue" @default.
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- W2083407361 doi "https://doi.org/10.1016/j.bbamem.2006.02.028" @default.
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