FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083417257> ?p ?o ?g. }

• W2083417257 endingPage "446" @default.
• W2083417257 startingPage "437" @default.
• W2083417257 abstract "Peripheral T-cell antigen receptor V beta (TCRV beta) repertoire is influenced by clonal deletion both in the thymus and periphery. Developing thymocytes expressing certain TCRV beta are deleted by endogenous superantigens presented on major histocompatibility complex (MHC) molecules in the thymus. Likewise, mature T cells bearing particular TCRV beta chains can be clonally deleted by superantigens in the periphery. The efficiency with which T cells expressing particular V beta subunits are deleted differs depending upon which coreceptor is expressed. Indeed, while deletion of V beta 11+ splenic T cells in CBA/J (Mls-1, a I-E, + MTV 9+) mice is quite efficient for CD4+ spleen T cells, it is much less efficient for CD8+ splenic T cells. If the difference in the efficiency of deletion is due solely to the coreceptor expressed, then a transgene encoding CD4 should increase the efficiency with which CD8+ cells are deleted. To address this question, we have produced CD4 transgenic (TG) mice that express physiologic levels of CD4 on all thymocytes and peripheral CD8 T cells. CD4 molecules expressed on CD8+ splenic T cells were associated with P56lck tyrosine kinase, and were functional as evidenced by their ability to facilitate class II alloreactivity. Furthermore, we found that ectopic expression of TG CD4 molecules on CD8+ cells was able to affect the efficiency of deletion in response to superantigen stimulation. In particular, deletion of TCRV beta 11+ T cells was much less efficient for CD8+ than for CD4+ T-cell subpopulations in (CBA/J x B6) F1 mice. However, expression of the CD4 transgene on CD8+ splenic T cells from these mice increased the efficiency of deletion in the CD8+ V beta 11 T cells. Interestingly, this effect was not observed in a mature CD8+ thymocyte subpopulation. The results in this report demonstrate that CD4 molecules are involved in peripheral deletion of TCRV beta 11+ T cells in (CBA/J x B6) F1 mice, and that the TCRV beta repertoire can be altered by ectopic expression of CD4 on all T-lineage cells." @default.
• W2083417257 created "2016-06-24" @default.
• W2083417257 creator A5013005567 @default.
• W2083417257 creator A5016460755 @default.
• W2083417257 creator A5053359905 @default.
• W2083417257 creator A5061720798 @default.
• W2083417257 creator A5068524115 @default.
• W2083417257 creator A5081014415 @default.
• W2083417257 creator A5091790780 @default.
• W2083417257 date "1997-12-01" @default.
• W2083417257 modified "2023-09-23" @default.
• W2083417257 title "CD4 regulates the efficiency of an endogenous superantigen‐induced clonal deletion of TCRVβ11 + cells in the periphery" @default.
• W2083417257 cites W1551490627 @default.
• W2083417257 cites W1708580610 @default.
• W2083417257 cites W18630108 @default.
• W2083417257 cites W1945938648 @default.
• W2083417257 cites W1961132966 @default.
• W2083417257 cites W1967456581 @default.
• W2083417257 cites W1967979720 @default.
• W2083417257 cites W1972354503 @default.
• W2083417257 cites W1975791322 @default.
• W2083417257 cites W1977542956 @default.
• W2083417257 cites W1978018492 @default.
• W2083417257 cites W1986356667 @default.
• W2083417257 cites W1995205975 @default.
• W2083417257 cites W1995313125 @default.
• W2083417257 cites W1999918512 @default.
• W2083417257 cites W2003501749 @default.
• W2083417257 cites W2007362831 @default.
• W2083417257 cites W2008299115 @default.
• W2083417257 cites W2009603041 @default.
• W2083417257 cites W2009907090 @default.
• W2083417257 cites W2017037387 @default.
• W2083417257 cites W2022978700 @default.
• W2083417257 cites W2024441858 @default.
• W2083417257 cites W2025081899 @default.
• W2083417257 cites W2028669354 @default.
• W2083417257 cites W2028862502 @default.
• W2083417257 cites W2033360952 @default.
• W2083417257 cites W2035079622 @default.
• W2083417257 cites W2036368914 @default.
• W2083417257 cites W2036419095 @default.
• W2083417257 cites W2043066069 @default.
• W2083417257 cites W2047372570 @default.
• W2083417257 cites W2047674370 @default.
• W2083417257 cites W2053275476 @default.
• W2083417257 cites W2058265969 @default.
• W2083417257 cites W2058885870 @default.
• W2083417257 cites W2060199817 @default.
• W2083417257 cites W2062999278 @default.
• W2083417257 cites W2070437307 @default.
• W2083417257 cites W2070442757 @default.
• W2083417257 cites W2072983673 @default.
• W2083417257 cites W2073753720 @default.
• W2083417257 cites W2078457332 @default.
• W2083417257 cites W2083393665 @default.
• W2083417257 cites W2083717129 @default.
• W2083417257 cites W2086764321 @default.
• W2083417257 cites W2087183640 @default.
• W2083417257 cites W208730735 @default.
• W2083417257 cites W2089703669 @default.
• W2083417257 cites W2099534464 @default.
• W2083417257 cites W2103228071 @default.
• W2083417257 cites W2123030732 @default.
• W2083417257 cites W2134352843 @default.
• W2083417257 cites W2136242443 @default.
• W2083417257 cites W2148426299 @default.
• W2083417257 cites W2154264945 @default.
• W2083417257 cites W2159049396 @default.
• W2083417257 cites W2165835604 @default.
• W2083417257 cites W2174800991 @default.
• W2083417257 doi "https://doi.org/10.1046/j.1365-2567.1997.00382.x" @default.
• W2083417257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1364148" @default.
• W2083417257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9497484" @default.
• W2083417257 hasPublicationYear "1997" @default.
• W2083417257 type Work @default.
• W2083417257 sameAs 2083417257 @default.
• W2083417257 citedByCount "2" @default.
• W2083417257 crossrefType "journal-article" @default.
• W2083417257 hasAuthorship W2083417257A5013005567 @default.
• W2083417257 hasAuthorship W2083417257A5016460755 @default.
• W2083417257 hasAuthorship W2083417257A5053359905 @default.
• W2083417257 hasAuthorship W2083417257A5061720798 @default.
• W2083417257 hasAuthorship W2083417257A5068524115 @default.
• W2083417257 hasAuthorship W2083417257A5081014415 @default.
• W2083417257 hasAuthorship W2083417257A5091790780 @default.
• W2083417257 hasBestOaLocation W20834172572 @default.
• W2083417257 hasConcept C147483822 @default.
• W2083417257 hasConcept C153911025 @default.
• W2083417257 hasConcept C154317977 @default.
• W2083417257 hasConcept C167672396 @default.
• W2083417257 hasConcept C19317047 @default.
• W2083417257 hasConcept C202751555 @default.
• W2083417257 hasConcept C203014093 @default.
• W2083417257 hasConcept C207936829 @default.
• W2083417257 hasConcept C2776090121 @default.
• W2083417257 hasConcept C2777868816 @default.
• W2083417257 hasConcept C36333154 @default.

• next