FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083418897> ?p ?o ?g. }

• W2083418897 endingPage "463" @default.
• W2083418897 startingPage "457" @default.
• W2083418897 abstract "A subpopulation of the CF-1 mouse strain contains a spontaneous mutation in the P-glycoprotein (Pgp) mdr1a gene, which leads to a lack of mdr1a expression in the placenta as well as brain and intestine. Individual CF-1 mice can be identified according to their Pgp status by a restriction fragment length polymorphism. Male and female mice selected on the basis of Pgp genotype were mated and the pregnant dams exposed during gestation to the known Pgp substrate, L-652,280, the 8,9 Z photoisomer of the naturally occurring avermectin Bla, which is known to produce cleft palate in mice. Fetal examination demonstrated that within individual litters, fetuses deficient in Pgp (-/-) were 100% susceptible to cleft palate, whereas their +/- heterozygote littermates were less sensitive. The homozygous +/+ fetuses with abundant Pgp were totally insensitive at the doses tested. The degree of chemical exposure of fetuses within each litter was inversely related to expression of placental Pgp, which was determined by the fetal genotype. These results demonstrate the importance of placental Pgp in protecting the fetus from potential teratogens and suggest that Pgp inhibitors should be carefully evaluated for their potential to increase susceptibility to chemical-induced teratogenesis." @default.
• W2083418897 created "2016-06-24" @default.
• W2083418897 creator A5009394304 @default.
• W2083418897 creator A5025204088 @default.
• W2083418897 creator A5032599842 @default.
• W2083418897 creator A5035602203 @default.
• W2083418897 creator A5084589380 @default.
• W2083418897 date "1998-07-01" @default.
• W2083418897 modified "2023-10-07" @default.
• W2083418897 title "Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice" @default.
• W2083418897 cites W1583339960 @default.
• W2083418897 cites W1858200607 @default.
• W2083418897 cites W1984631756 @default.
• W2083418897 cites W1984820569 @default.
• W2083418897 cites W2005223159 @default.
• W2083418897 cites W2007931369 @default.
• W2083418897 cites W2009961226 @default.
• W2083418897 cites W2021759214 @default.
• W2083418897 cites W2024463580 @default.
• W2083418897 cites W2025271457 @default.
• W2083418897 cites W2038293434 @default.
• W2083418897 cites W2052229830 @default.
• W2083418897 cites W2062903328 @default.
• W2083418897 cites W2068979346 @default.
• W2083418897 cites W2078877172 @default.
• W2083418897 cites W2094536655 @default.
• W2083418897 cites W2102458361 @default.
• W2083418897 cites W2112001901 @default.
• W2083418897 cites W2118234018 @default.
• W2083418897 cites W2166153381 @default.
• W2083418897 cites W2169212793 @default.
• W2083418897 cites W2198182531 @default.
• W2083418897 doi "https://doi.org/10.1016/s0890-6238(98)00027-6" @default.
• W2083418897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9717696" @default.
• W2083418897 hasPublicationYear "1998" @default.
• W2083418897 type Work @default.
• W2083418897 sameAs 2083418897 @default.
• W2083418897 citedByCount "294" @default.
• W2083418897 countsByYear W20834188972012 @default.
• W2083418897 countsByYear W20834188972013 @default.
• W2083418897 countsByYear W20834188972014 @default.
• W2083418897 countsByYear W20834188972015 @default.
• W2083418897 countsByYear W20834188972016 @default.
• W2083418897 countsByYear W20834188972017 @default.
• W2083418897 countsByYear W20834188972018 @default.
• W2083418897 countsByYear W20834188972019 @default.
• W2083418897 countsByYear W20834188972020 @default.
• W2083418897 countsByYear W20834188972021 @default.
• W2083418897 countsByYear W20834188972022 @default.
• W2083418897 countsByYear W20834188972023 @default.
• W2083418897 crossrefType "journal-article" @default.
• W2083418897 hasAuthorship W2083418897A5009394304 @default.
• W2083418897 hasAuthorship W2083418897A5025204088 @default.
• W2083418897 hasAuthorship W2083418897A5032599842 @default.
• W2083418897 hasAuthorship W2083418897A5035602203 @default.
• W2083418897 hasAuthorship W2083418897A5084589380 @default.
• W2083418897 hasConcept C104317684 @default.
• W2083418897 hasConcept C126322002 @default.
• W2083418897 hasConcept C133936738 @default.
• W2083418897 hasConcept C134018914 @default.
• W2083418897 hasConcept C135763542 @default.
• W2083418897 hasConcept C153471976 @default.
• W2083418897 hasConcept C16685009 @default.
• W2083418897 hasConcept C172680121 @default.
• W2083418897 hasConcept C2776953305 @default.
• W2083418897 hasConcept C2777928079 @default.
• W2083418897 hasConcept C2778707650 @default.
• W2083418897 hasConcept C2779234561 @default.
• W2083418897 hasConcept C2779429622 @default.
• W2083418897 hasConcept C46973012 @default.
• W2083418897 hasConcept C501593827 @default.
• W2083418897 hasConcept C54355233 @default.
• W2083418897 hasConcept C6557445 @default.
• W2083418897 hasConcept C71924100 @default.
• W2083418897 hasConcept C86803240 @default.
• W2083418897 hasConceptScore W2083418897C104317684 @default.
• W2083418897 hasConceptScore W2083418897C126322002 @default.
• W2083418897 hasConceptScore W2083418897C133936738 @default.
• W2083418897 hasConceptScore W2083418897C134018914 @default.
• W2083418897 hasConceptScore W2083418897C135763542 @default.
• W2083418897 hasConceptScore W2083418897C153471976 @default.
• W2083418897 hasConceptScore W2083418897C16685009 @default.
• W2083418897 hasConceptScore W2083418897C172680121 @default.
• W2083418897 hasConceptScore W2083418897C2776953305 @default.
• W2083418897 hasConceptScore W2083418897C2777928079 @default.
• W2083418897 hasConceptScore W2083418897C2778707650 @default.
• W2083418897 hasConceptScore W2083418897C2779234561 @default.
• W2083418897 hasConceptScore W2083418897C2779429622 @default.
• W2083418897 hasConceptScore W2083418897C46973012 @default.
• W2083418897 hasConceptScore W2083418897C501593827 @default.
• W2083418897 hasConceptScore W2083418897C54355233 @default.
• W2083418897 hasConceptScore W2083418897C6557445 @default.
• W2083418897 hasConceptScore W2083418897C71924100 @default.
• W2083418897 hasConceptScore W2083418897C86803240 @default.
• W2083418897 hasIssue "4" @default.
• W2083418897 hasLocation W20834188971 @default.
• W2083418897 hasLocation W20834188972 @default.
• W2083418897 hasOpenAccess W2083418897 @default.

• next