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• W2083419306 abstract "The prescription drugs procainamide (PA) and hydralazine (HYD) are associated with the induction of autoimmunity and a clinical syndrome called drug-induced lupus. Since PA- and HYD-induced autoantibodies are directed primarily against histones and histones are prime acceptors of poly (ADP-ribose) (PADPR), we have investigated the effects of PA and HYD on the activity of poly (ADP-ribose) polymerase (PADPRP). Control substances, with structures similar to PA and HYD but not known to induce lupus, included N-acetylprocainamide (NAPA) and the amino acids phenylalanine, tryptophan and proline, and their amide derivatives. Wil-2 cells were incubated in 0.5-50 μM PA, NAPA and HYD, which included therapeutic concentrations of these drugs. The mean enhancement of incorporation of [ 3 H]-nicotinamide adenine dinucleotide (NAD) into PADPR was 1.84 (P = 0.005) with PA, with HYD 1.48 (P = 0.029), and with NAPA 1.38 (P = 0.036). This increase was suppressed by 3-aminobenzamide, an inhibitor of PADPRP activity. Little or no increase in [ 3 H]-NAD incorporation was observed with equivalent concentrations of phenylalanine, phenylalaninamide or tryptophan. However, a 1.29-fold increase was noted with 0.5 μM tryptophanamide, a 1.26-fold increase with 0.5 μM prolinamide and a 1.4-fold increase with 50 μM proline. PA increased PADPRP activity in B- and T-cell lines but not in promyelocytic leukemia or epithelial cell lines. Since poly (ADP-ribosylation) is important in the cellular response to various agents, the increased ADP-ribosylation of intracellular molecules may be a key event in the induction of autoantibodies." @default.
• W2083419306 created "2016-06-24" @default.
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• W2083419306 date "1993-06-01" @default.
• W2083419306 modified "2023-09-27" @default.
• W2083419306 title "Effect of Procainamide and Hydralazine on Poly (ADP-ribosylation) in Cell Lines" @default.
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• W2083419306 doi "https://doi.org/10.1177/096120339300200307" @default.
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