FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083426921> ?p ?o ?g. }

• W2083426921 endingPage "2929" @default.
• W2083426921 startingPage "2919" @default.
• W2083426921 abstract "Abstract NY‐ESO‐1 is a germ cell antigen aberrantly expressed by different tumor types that elicits strong humoral and cellular immune responses, representing one of the most promising candidates for vaccination of cancer patients. A detailed analysis of CD8 + T cells generated in vaccine trials using NY‐ESO‐1‐derived peptides (157–165 and 157–167) revealed that the dominant immune response was directed against a cryptic epitope (159–167) diverting the immune response from tumor recognition. Only CTL reactivity to the NY‐ESO‐1 157–165 peptide appeared to be capable of lysing NY‐ESO‐1/HLA‐A0201‐expressing tumor cells. To study the process of NY‐ESO‐1 peptide presentation by tumor cells in more detail we generated a high‐affinity (K D =60 nM) antibody fragment that specifically recognizes the NY‐ESO‐1 157–165 peptide/HLA‐A0201 complex. Peptide variants such as the NY‐ESO‐1 157–167 peptide or the cryptic NY‐ESO‐1 159–167 peptide were not recognized. The antibody fragment blocked in a dose‐dependent fashion the recognition of NY‐ESO‐1/HLA‐A2‐positive tumor cells by NY‐ESO‐1 157–165 peptide‐specific CD8 + T cells. This antibody fragment is a novel reagent that binds with TCR‐like specificity to the NY‐ESO‐1 157–165 /HLA‐A2 complex thus distinguishing between CTL responses against immunological meaningful or cryptic NY‐ESO‐1‐derived peptides. It may therefore become a useful monitoring tool for the development of NY‐ESO‐1‐based cancer vaccines." @default.
• W2083426921 created "2016-06-24" @default.
• W2083426921 creator A5010497741 @default.
• W2083426921 creator A5022980245 @default.
• W2083426921 creator A5024404816 @default.
• W2083426921 creator A5030025370 @default.
• W2083426921 creator A5038456003 @default.
• W2083426921 creator A5039405774 @default.
• W2083426921 creator A5045248612 @default.
• W2083426921 creator A5046912050 @default.
• W2083426921 creator A5050408747 @default.
• W2083426921 creator A5052238969 @default.
• W2083426921 creator A5052721036 @default.
• W2083426921 creator A5078046623 @default.
• W2083426921 creator A5089344430 @default.
• W2083426921 date "2004-08-24" @default.
• W2083426921 modified "2023-10-15" @default.
• W2083426921 title "Dissecting cytotoxic T cell responses towards the NY-ESO-1 protein by peptide/MHC-specific antibody fragments" @default.
• W2083426921 cites W1558740094 @default.
• W2083426921 cites W1656802595 @default.
• W2083426921 cites W1941694730 @default.
• W2083426921 cites W1975213486 @default.
• W2083426921 cites W1986216579 @default.
• W2083426921 cites W2003156803 @default.
• W2083426921 cites W2006987944 @default.
• W2083426921 cites W2015737099 @default.
• W2083426921 cites W2025827008 @default.
• W2083426921 cites W2027271084 @default.
• W2083426921 cites W2034846292 @default.
• W2083426921 cites W2035244690 @default.
• W2083426921 cites W2036851895 @default.
• W2083426921 cites W2042174530 @default.
• W2083426921 cites W2055724916 @default.
• W2083426921 cites W2065042783 @default.
• W2083426921 cites W2067069532 @default.
• W2083426921 cites W2075649737 @default.
• W2083426921 cites W2077861376 @default.
• W2083426921 cites W2096385955 @default.
• W2083426921 cites W2105480051 @default.
• W2083426921 cites W2117289217 @default.
• W2083426921 cites W2143935255 @default.
• W2083426921 cites W2163357710 @default.
• W2083426921 cites W2165142928 @default.
• W2083426921 cites W4231014363 @default.
• W2083426921 cites W4245127498 @default.
• W2083426921 doi "https://doi.org/10.1002/eji.200425297" @default.
• W2083426921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15368308" @default.
• W2083426921 hasPublicationYear "2004" @default.
• W2083426921 type Work @default.
• W2083426921 sameAs 2083426921 @default.
• W2083426921 citedByCount "67" @default.
• W2083426921 countsByYear W20834269212012 @default.
• W2083426921 countsByYear W20834269212013 @default.
• W2083426921 countsByYear W20834269212015 @default.
• W2083426921 countsByYear W20834269212017 @default.
• W2083426921 countsByYear W20834269212018 @default.
• W2083426921 countsByYear W20834269212019 @default.
• W2083426921 countsByYear W20834269212020 @default.
• W2083426921 countsByYear W20834269212021 @default.
• W2083426921 countsByYear W20834269212022 @default.
• W2083426921 countsByYear W20834269212023 @default.
• W2083426921 crossrefType "journal-article" @default.
• W2083426921 hasAuthorship W2083426921A5010497741 @default.
• W2083426921 hasAuthorship W2083426921A5022980245 @default.
• W2083426921 hasAuthorship W2083426921A5024404816 @default.
• W2083426921 hasAuthorship W2083426921A5030025370 @default.
• W2083426921 hasAuthorship W2083426921A5038456003 @default.
• W2083426921 hasAuthorship W2083426921A5039405774 @default.
• W2083426921 hasAuthorship W2083426921A5045248612 @default.
• W2083426921 hasAuthorship W2083426921A5046912050 @default.
• W2083426921 hasAuthorship W2083426921A5050408747 @default.
• W2083426921 hasAuthorship W2083426921A5052238969 @default.
• W2083426921 hasAuthorship W2083426921A5052721036 @default.
• W2083426921 hasAuthorship W2083426921A5078046623 @default.
• W2083426921 hasAuthorship W2083426921A5089344430 @default.
• W2083426921 hasBestOaLocation W20834269211 @default.
• W2083426921 hasConcept C147483822 @default.
• W2083426921 hasConcept C147969180 @default.
• W2083426921 hasConcept C153911025 @default.
• W2083426921 hasConcept C154317977 @default.
• W2083426921 hasConcept C159654299 @default.
• W2083426921 hasConcept C167672396 @default.
• W2083426921 hasConcept C195616568 @default.
• W2083426921 hasConcept C202751555 @default.
• W2083426921 hasConcept C203014093 @default.
• W2083426921 hasConcept C207936829 @default.
• W2083426921 hasConcept C2776789287 @default.
• W2083426921 hasConcept C2777701055 @default.
• W2083426921 hasConcept C2779281246 @default.
• W2083426921 hasConcept C2780674031 @default.
• W2083426921 hasConcept C55493867 @default.
• W2083426921 hasConcept C86803240 @default.
• W2083426921 hasConcept C8891405 @default.
• W2083426921 hasConceptScore W2083426921C147483822 @default.
• W2083426921 hasConceptScore W2083426921C147969180 @default.
• W2083426921 hasConceptScore W2083426921C153911025 @default.
• W2083426921 hasConceptScore W2083426921C154317977 @default.
• W2083426921 hasConceptScore W2083426921C159654299 @default.

• next