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- W2083429704 abstract "1. The rate constant k of the inactivation of red cell choline transport by 1 mM N-ethylmaleimide has been measured under various conditions. 2. k has a control value between 0.17 and 0.30 min−1; in the presence of a saturating concentration of a competitive inhibitor (decamethonium) outside the cell k is about 0.004 min−1; when there is a saturating concentration of choline inside the cell k is about 0.04 min−1; when there is a saturating concentration of substrate (choline, tetramethylammonium or N-methylpyridinium) outside the cell k is about 0.7 min−1; in the presence of a saturating concentration of competitive inhibitor (metanephrine) inside the cell k is about 1.5. times greater still, and is the same as k in the presence simultaneously of a large concentration of substrate outside and of competitive inhibitor inside. 3. The concentrations of substrate and competitive inhibitor giving half-maximal changes in k are equal to Km and Ki values for transport. 4. These results suggest that the transport system exists in two conformational states, which behave like the inward-facing and outward-facing states of a “carrier”. The results are quantitatively consistent with the hypothesis that N-ethylmaleimide reacts with inward-facing carrier. Non-carrier models of transport proposed recently cannot explain the result." @default.
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- W2083429704 date "1973-06-01" @default.
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- W2083429704 title "Evidence for the carrier model of transport from the inhibition by N-ethylmaleimide of choline transport across the human red cell membrane" @default.
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- W2083429704 doi "https://doi.org/10.1016/0005-2736(73)90260-5" @default.
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