Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083430802> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2083430802 abstract "We investigated dihydropyrimidine dehydrogenase (DPD) activity and its expression in breast cancer cases, and evaluated the prognostic significance of DPD expression in invasive breast cancer. A total of 49 paired of breast cancer tissues and the adjacent normal breast tissues were evaluated in this study. DPD expression of 191 patients with invasive breast cancer was also evaluated immunohistochemically. DPD activity in breast cancer ranged from 13.4-360.0 pmol/mg/min (mean, 162.9 pmol/mg/min). DPD activity in breast cancer tissues was significantly (p<0.001) higher than in adjacent normal breast tissue. DPD activity was significantly higher in DPD expression-positive tumors than DPD expression-negative tumors. The level of DPD activity was correlated with DPD expression. Patients with DPD expression-positive tumors had a significantly (p<0.05) poorer prognosis in disease-free survival compared to those with DPD-negative tumors. When evaluated in patients treated with 5-FU or 5-FU derivatives, DPD expression was a significantly (p<0.05) poorer prognostic factor in disease-free and overall survival. Using a Cox proportional hazards model, nodal status, ER status, and DPD expression were independent prognostic factors for both disease-free and overall survival. In conclusion, DPD expression may function as a marker of DPD activity and may be a prognostic indicator for patients with breast cancer." @default.
- W2083430802 created "2016-06-24" @default.
- W2083430802 creator A5002514266 @default.
- W2083430802 creator A5011614398 @default.
- W2083430802 creator A5025060410 @default.
- W2083430802 creator A5028112304 @default.
- W2083430802 creator A5040999321 @default.
- W2083430802 creator A5052407595 @default.
- W2083430802 creator A5089611935 @default.
- W2083430802 creator A5090509013 @default.
- W2083430802 creator A5091788286 @default.
- W2083430802 date "2004-01-01" @default.
- W2083430802 modified "2023-09-27" @default.
- W2083430802 title "DPD activity and immunohistochemical DPD expression in human breast cancer" @default.
- W2083430802 doi "https://doi.org/10.3892/or.11.1.65" @default.
- W2083430802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14654904" @default.
- W2083430802 hasPublicationYear "2004" @default.
- W2083430802 type Work @default.
- W2083430802 sameAs 2083430802 @default.
- W2083430802 citedByCount "9" @default.
- W2083430802 countsByYear W20834308022013 @default.
- W2083430802 countsByYear W20834308022014 @default.
- W2083430802 countsByYear W20834308022021 @default.
- W2083430802 countsByYear W20834308022023 @default.
- W2083430802 crossrefType "journal-article" @default.
- W2083430802 hasAuthorship W2083430802A5002514266 @default.
- W2083430802 hasAuthorship W2083430802A5011614398 @default.
- W2083430802 hasAuthorship W2083430802A5025060410 @default.
- W2083430802 hasAuthorship W2083430802A5028112304 @default.
- W2083430802 hasAuthorship W2083430802A5040999321 @default.
- W2083430802 hasAuthorship W2083430802A5052407595 @default.
- W2083430802 hasAuthorship W2083430802A5089611935 @default.
- W2083430802 hasAuthorship W2083430802A5090509013 @default.
- W2083430802 hasAuthorship W2083430802A5091788286 @default.
- W2083430802 hasConcept C121608353 @default.
- W2083430802 hasConcept C123321153 @default.
- W2083430802 hasConcept C126322002 @default.
- W2083430802 hasConcept C143998085 @default.
- W2083430802 hasConcept C204232928 @default.
- W2083430802 hasConcept C2778050828 @default.
- W2083430802 hasConcept C2780456651 @default.
- W2083430802 hasConcept C2781018059 @default.
- W2083430802 hasConcept C29537977 @default.
- W2083430802 hasConcept C502942594 @default.
- W2083430802 hasConcept C50382708 @default.
- W2083430802 hasConcept C530470458 @default.
- W2083430802 hasConcept C67082663 @default.
- W2083430802 hasConcept C71924100 @default.
- W2083430802 hasConceptScore W2083430802C121608353 @default.
- W2083430802 hasConceptScore W2083430802C123321153 @default.
- W2083430802 hasConceptScore W2083430802C126322002 @default.
- W2083430802 hasConceptScore W2083430802C143998085 @default.
- W2083430802 hasConceptScore W2083430802C204232928 @default.
- W2083430802 hasConceptScore W2083430802C2778050828 @default.
- W2083430802 hasConceptScore W2083430802C2780456651 @default.
- W2083430802 hasConceptScore W2083430802C2781018059 @default.
- W2083430802 hasConceptScore W2083430802C29537977 @default.
- W2083430802 hasConceptScore W2083430802C502942594 @default.
- W2083430802 hasConceptScore W2083430802C50382708 @default.
- W2083430802 hasConceptScore W2083430802C530470458 @default.
- W2083430802 hasConceptScore W2083430802C67082663 @default.
- W2083430802 hasConceptScore W2083430802C71924100 @default.
- W2083430802 hasLocation W20834308021 @default.
- W2083430802 hasLocation W20834308022 @default.
- W2083430802 hasOpenAccess W2083430802 @default.
- W2083430802 hasPrimaryLocation W20834308021 @default.
- W2083430802 hasRelatedWork W1965419066 @default.
- W2083430802 hasRelatedWork W1966302763 @default.
- W2083430802 hasRelatedWork W1967421271 @default.
- W2083430802 hasRelatedWork W1978718921 @default.
- W2083430802 hasRelatedWork W1979000353 @default.
- W2083430802 hasRelatedWork W1994923686 @default.
- W2083430802 hasRelatedWork W1997056244 @default.
- W2083430802 hasRelatedWork W2017593808 @default.
- W2083430802 hasRelatedWork W2025354192 @default.
- W2083430802 hasRelatedWork W2033873587 @default.
- W2083430802 hasRelatedWork W2039026077 @default.
- W2083430802 hasRelatedWork W2041958241 @default.
- W2083430802 hasRelatedWork W2059229658 @default.
- W2083430802 hasRelatedWork W2076290497 @default.
- W2083430802 hasRelatedWork W2096410299 @default.
- W2083430802 hasRelatedWork W2107222746 @default.
- W2083430802 hasRelatedWork W2153400362 @default.
- W2083430802 hasRelatedWork W2169532459 @default.
- W2083430802 hasRelatedWork W2170140374 @default.
- W2083430802 hasRelatedWork W224553751 @default.
- W2083430802 isParatext "false" @default.
- W2083430802 isRetracted "false" @default.
- W2083430802 magId "2083430802" @default.
- W2083430802 workType "article" @default.