FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083434189> ?p ?o ?g. }

• W2083434189 endingPage "36844" @default.
• W2083434189 startingPage "36837" @default.
• W2083434189 abstract "Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system caused by binding of anti-aquaporin-4 (AQP4) autoantibodies (NMO-IgG) to AQP4 on astrocytes. A screen was developed to identify inhibitors of NMO-IgG-dependent, complement-dependent cytotoxicity. Screening of 50,000 synthetic small molecules was done using CHO cells expressing human AQP4 and a human NMO recombinant monoclonal antibody (rAb-53). The screen yielded pyrano[2,3-c]pyrazoles that blocked rAb-53 binding to AQP4 and prevented cytotoxicity in cell culture and spinal cord slice models of NMO. Structure-activity analysis of 82 analogs yielded a blocker with IC(50) ∼ 6 μm. Analysis of the blocker mechanism indicated idiotype specificity, as (i) pyrano[2,3-c]pyrazoles did not prevent AQP4 binding or cytotoxicity of other NMO-IgGs, and (ii) surface plasmon resonance showed specific rAb-53 binding. Antibody structure modeling and docking suggested a putative binding site near the complementarity-determining regions. Small molecules with idiotype-specific antibody targeting may be useful as research tools and therapeutics." @default.
• W2083434189 created "2016-06-24" @default.
• W2083434189 creator A5016397545 @default.
• W2083434189 creator A5025269471 @default.
• W2083434189 creator A5025355667 @default.
• W2083434189 creator A5027298425 @default.
• W2083434189 creator A5027982493 @default.
• W2083434189 creator A5037051366 @default.
• W2083434189 creator A5042356327 @default.
• W2083434189 creator A5056450584 @default.
• W2083434189 date "2012-10-01" @default.
• W2083434189 modified "2023-09-28" @default.
• W2083434189 title "A Small-molecule Screen Yields Idiotype-specific Blockers of Neuromyelitis Optica Immunoglobulin G Binding to Aquaporin-4" @default.
• W2083434189 cites W1527139044 @default.
• W2083434189 cites W1535419310 @default.
• W2083434189 cites W1970547229 @default.
• W2083434189 cites W1971242419 @default.
• W2083434189 cites W1978994973 @default.
• W2083434189 cites W2002083743 @default.
• W2083434189 cites W2015868606 @default.
• W2083434189 cites W2018439132 @default.
• W2083434189 cites W2021512471 @default.
• W2083434189 cites W2027358863 @default.
• W2083434189 cites W2036172456 @default.
• W2083434189 cites W2056405400 @default.
• W2083434189 cites W2065303540 @default.
• W2083434189 cites W2065960244 @default.
• W2083434189 cites W2066056753 @default.
• W2083434189 cites W2066657308 @default.
• W2083434189 cites W2067927161 @default.
• W2083434189 cites W2072845515 @default.
• W2083434189 cites W2077427574 @default.
• W2083434189 cites W2091085852 @default.
• W2083434189 cites W2093787075 @default.
• W2083434189 cites W2096729219 @default.
• W2083434189 cites W2111296273 @default.
• W2083434189 cites W2124292468 @default.
• W2083434189 cites W2134389315 @default.
• W2083434189 cites W2136132690 @default.
• W2083434189 cites W2147444468 @default.
• W2083434189 cites W2156918730 @default.
• W2083434189 cites W2157805786 @default.
• W2083434189 cites W2157925921 @default.
• W2083434189 cites W2162561057 @default.
• W2083434189 cites W2171013521 @default.
• W2083434189 cites W2172238479 @default.
• W2083434189 doi "https://doi.org/10.1074/jbc.m112.408716" @default.
• W2083434189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3481286" @default.
• W2083434189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22989877" @default.
• W2083434189 hasPublicationYear "2012" @default.
• W2083434189 type Work @default.
• W2083434189 sameAs 2083434189 @default.
• W2083434189 citedByCount "13" @default.
• W2083434189 countsByYear W20834341892013 @default.
• W2083434189 countsByYear W20834341892014 @default.
• W2083434189 countsByYear W20834341892015 @default.
• W2083434189 countsByYear W20834341892016 @default.
• W2083434189 countsByYear W20834341892018 @default.
• W2083434189 countsByYear W20834341892020 @default.
• W2083434189 countsByYear W20834341892023 @default.
• W2083434189 crossrefType "journal-article" @default.
• W2083434189 hasAuthorship W2083434189A5016397545 @default.
• W2083434189 hasAuthorship W2083434189A5025269471 @default.
• W2083434189 hasAuthorship W2083434189A5025355667 @default.
• W2083434189 hasAuthorship W2083434189A5027298425 @default.
• W2083434189 hasAuthorship W2083434189A5027982493 @default.
• W2083434189 hasAuthorship W2083434189A5037051366 @default.
• W2083434189 hasAuthorship W2083434189A5042356327 @default.
• W2083434189 hasAuthorship W2083434189A5056450584 @default.
• W2083434189 hasBestOaLocation W20834341891 @default.
• W2083434189 hasConcept C109316439 @default.
• W2083434189 hasConcept C153911025 @default.
• W2083434189 hasConcept C15755913 @default.
• W2083434189 hasConcept C159654299 @default.
• W2083434189 hasConcept C163764329 @default.
• W2083434189 hasConcept C185592680 @default.
• W2083434189 hasConcept C202751555 @default.
• W2083434189 hasConcept C203014093 @default.
• W2083434189 hasConcept C2781137167 @default.
• W2083434189 hasConcept C542903549 @default.
• W2083434189 hasConcept C55493867 @default.
• W2083434189 hasConcept C74505204 @default.
• W2083434189 hasConcept C86803240 @default.
• W2083434189 hasConceptScore W2083434189C109316439 @default.
• W2083434189 hasConceptScore W2083434189C153911025 @default.
• W2083434189 hasConceptScore W2083434189C15755913 @default.
• W2083434189 hasConceptScore W2083434189C159654299 @default.
• W2083434189 hasConceptScore W2083434189C163764329 @default.
• W2083434189 hasConceptScore W2083434189C185592680 @default.
• W2083434189 hasConceptScore W2083434189C202751555 @default.
• W2083434189 hasConceptScore W2083434189C203014093 @default.
• W2083434189 hasConceptScore W2083434189C2781137167 @default.
• W2083434189 hasConceptScore W2083434189C542903549 @default.
• W2083434189 hasConceptScore W2083434189C55493867 @default.
• W2083434189 hasConceptScore W2083434189C74505204 @default.
• W2083434189 hasConceptScore W2083434189C86803240 @default.
• W2083434189 hasIssue "44" @default.
• W2083434189 hasLocation W20834341891 @default.

• next