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• W2083436660 endingPage "3588" @default.
• W2083436660 startingPage "3573" @default.
• W2083436660 abstract "We have previously identified a novel family of proteins called the GGAs (Golgi-localized, gamma-ear-containing, ADP-ribosylation factor-binding proteins). These proteins consist of an NH(2)-terminal VHS domain, followed by a GAT domain, a variable domain, and a gamma-adaptin ear homology domain. Studies from our own laboratory and others, making use of both yeast and mammals cells, indicate that the GGAs facilitate trafficking from the trans-Golgi network to endosomes. Here we have further investigated the function of the GGAs. We find that GGA-deficient yeast are not only defective in vacuolar protein sorting but they are also impaired in their ability to process alpha-factor. Using deletion mutants and chimeras, we show that the VHS domain is required for GGA function and that the VHS domain from Vps27p will not substitute for the GGA VHS domain. In contrast, the gamma-adaptin ear homology domain contributes to GGA function but is not absolutely required, and full function can be restored by replacing the GGA ear domain with the gamma-adaptin ear domain. Deleting the gamma-adaptin gene together with the two GGA genes exacerbates the phenotype in yeast, suggesting that they function on parallel pathways. In mammalian cells, the association of GGAs with the membrane is extremely unstable, which may account for their absence from purified clathrin-coated vesicles. Double- and triple-labeling immunofluorescence experiments indicate that the GGAs and AP-1 are associated with distinct populations of clathrin-coated vesicles budding from the trans-Golgi network. Together with results from other studies, our findings suggest that the GGAs act as monomeric adaptors, with the four domains involved in cargo selection, membrane localization, clathrin binding, and accessory protein recruitment." @default.
• W2083436660 created "2016-06-24" @default.
• W2083436660 creator A5013650036 @default.
• W2083436660 creator A5035413956 @default.
• W2083436660 creator A5085256243 @default.
• W2083436660 date "2001-11-01" @default.
• W2083436660 modified "2023-09-27" @default.
• W2083436660 title "Golgi-localized, γ-Ear-containing, ADP-Ribosylation Factor-binding Proteins: Roles of the Different Domains and Comparison with AP-1 and Clathrin" @default.
• W2083436660 cites W149688775 @default.
• W2083436660 cites W1564784444 @default.
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• W2083436660 cites W1976483253 @default.
• W2083436660 cites W1979815209 @default.
• W2083436660 cites W1985859776 @default.
• W2083436660 cites W1986805207 @default.
• W2083436660 cites W1987119713 @default.
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• W2083436660 cites W1992968802 @default.
• W2083436660 cites W1994266010 @default.
• W2083436660 cites W1997957892 @default.
• W2083436660 cites W2003560862 @default.
• W2083436660 cites W2003589540 @default.
• W2083436660 cites W2004404376 @default.
• W2083436660 cites W2006037420 @default.
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• W2083436660 cites W2015610211 @default.
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• W2083436660 cites W2043835841 @default.
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• W2083436660 doi "https://doi.org/10.1091/mbc.12.11.3573" @default.
• W2083436660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/60277" @default.
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