Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083436699> ?p ?o ?g. }
- W2083436699 endingPage "156" @default.
- W2083436699 startingPage "149" @default.
- W2083436699 abstract "In an attempt to identify the cell subpopulation involved in the humoral leukocyte adherence inhibition (H-LAI) reaction, mononuclear leukocytes were fractionated and the response with the different cell populations was measured in the H-LAI assay using sera from lung cancer patients and a lung cancer associated antigen. The monocytes were found to exhibit a suppressive effect on the H-LAI response. The B-lymphocytes seemed not to take an active part in the reaction. Depletion of the T-lymphocytes abolished the reaction. Subsequent studies on the T-lymphocyte subpopulations revealed that removal of the T4-cells had little effect while removal of the T8-cells resulted in complete abrogation of the H-LAI response. Direct blocking by monoclonal antibodies against the T4 and T8 surface determinants gave additional support for the T8-cell dependency of the H-LAI assay. The cells that specifically were induced to loose adherence in the H-LAI assay upon incubation with serum from a lung cancer patient and lung cancer associated antigen were also analyzed. Compared to the total mononuclear leukocyte population, the relative content of monocytes and B-cells were lower in the non-adherent population. An increase was found in the relative number of T-cells. While the relative number of T4-cells decreased, the content of T8-cells was significantly increased. Furthermore, a direct correlation was found between the loss of adherence of the T8-subpopulation and the index of the H-LAI response. The present study indicates the T8-subpopulation of the T-lymphocytes to be involved both in the effector and responder side of the H-LAI reaction and gives implications for an immunological reaction behind the response of the H-LAI assay." @default.
- W2083436699 created "2016-06-24" @default.
- W2083436699 creator A5012642760 @default.
- W2083436699 creator A5050192655 @default.
- W2083436699 creator A5085579062 @default.
- W2083436699 date "1987-02-01" @default.
- W2083436699 modified "2023-09-25" @default.
- W2083436699 title "Cell-populations involved in the humoral leukocyte adherence inhibition reaction. The T8-suppressor/cytotoxic cells are both effectors and responders" @default.
- W2083436699 cites W1528280015 @default.
- W2083436699 cites W1923145851 @default.
- W2083436699 cites W1963984598 @default.
- W2083436699 cites W1980334184 @default.
- W2083436699 cites W1981070246 @default.
- W2083436699 cites W1982379191 @default.
- W2083436699 cites W1984853686 @default.
- W2083436699 cites W1988227412 @default.
- W2083436699 cites W1997141186 @default.
- W2083436699 cites W2008384204 @default.
- W2083436699 cites W2014746177 @default.
- W2083436699 cites W2022930957 @default.
- W2083436699 cites W2052154101 @default.
- W2083436699 cites W2053412939 @default.
- W2083436699 cites W2065272367 @default.
- W2083436699 cites W2065965178 @default.
- W2083436699 cites W2067615306 @default.
- W2083436699 cites W2081888949 @default.
- W2083436699 cites W2088995866 @default.
- W2083436699 cites W2117085010 @default.
- W2083436699 cites W2124568244 @default.
- W2083436699 cites W2126616695 @default.
- W2083436699 cites W2160274453 @default.
- W2083436699 cites W2400896855 @default.
- W2083436699 cites W2492681023 @default.
- W2083436699 cites W4313313433 @default.
- W2083436699 cites W85114604 @default.
- W2083436699 doi "https://doi.org/10.1016/0277-5379(87)90008-3" @default.
- W2083436699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2965016" @default.
- W2083436699 hasPublicationYear "1987" @default.
- W2083436699 type Work @default.
- W2083436699 sameAs 2083436699 @default.
- W2083436699 citedByCount "0" @default.
- W2083436699 crossrefType "journal-article" @default.
- W2083436699 hasAuthorship W2083436699A5012642760 @default.
- W2083436699 hasAuthorship W2083436699A5050192655 @default.
- W2083436699 hasAuthorship W2083436699A5085579062 @default.
- W2083436699 hasConcept C126322002 @default.
- W2083436699 hasConcept C137061746 @default.
- W2083436699 hasConcept C147483822 @default.
- W2083436699 hasConcept C1491633281 @default.
- W2083436699 hasConcept C153911025 @default.
- W2083436699 hasConcept C154317977 @default.
- W2083436699 hasConcept C159654299 @default.
- W2083436699 hasConcept C202751555 @default.
- W2083436699 hasConcept C203014093 @default.
- W2083436699 hasConcept C2776090121 @default.
- W2083436699 hasConcept C2776256026 @default.
- W2083436699 hasConcept C2777761686 @default.
- W2083436699 hasConcept C2778740727 @default.
- W2083436699 hasConcept C2908647359 @default.
- W2083436699 hasConcept C55493867 @default.
- W2083436699 hasConcept C71924100 @default.
- W2083436699 hasConcept C86803240 @default.
- W2083436699 hasConcept C8891405 @default.
- W2083436699 hasConcept C99454951 @default.
- W2083436699 hasConceptScore W2083436699C126322002 @default.
- W2083436699 hasConceptScore W2083436699C137061746 @default.
- W2083436699 hasConceptScore W2083436699C147483822 @default.
- W2083436699 hasConceptScore W2083436699C1491633281 @default.
- W2083436699 hasConceptScore W2083436699C153911025 @default.
- W2083436699 hasConceptScore W2083436699C154317977 @default.
- W2083436699 hasConceptScore W2083436699C159654299 @default.
- W2083436699 hasConceptScore W2083436699C202751555 @default.
- W2083436699 hasConceptScore W2083436699C203014093 @default.
- W2083436699 hasConceptScore W2083436699C2776090121 @default.
- W2083436699 hasConceptScore W2083436699C2776256026 @default.
- W2083436699 hasConceptScore W2083436699C2777761686 @default.
- W2083436699 hasConceptScore W2083436699C2778740727 @default.
- W2083436699 hasConceptScore W2083436699C2908647359 @default.
- W2083436699 hasConceptScore W2083436699C55493867 @default.
- W2083436699 hasConceptScore W2083436699C71924100 @default.
- W2083436699 hasConceptScore W2083436699C86803240 @default.
- W2083436699 hasConceptScore W2083436699C8891405 @default.
- W2083436699 hasConceptScore W2083436699C99454951 @default.
- W2083436699 hasIssue "2" @default.
- W2083436699 hasLocation W20834366991 @default.
- W2083436699 hasLocation W20834366992 @default.
- W2083436699 hasOpenAccess W2083436699 @default.
- W2083436699 hasPrimaryLocation W20834366991 @default.
- W2083436699 hasRelatedWork W1484759019 @default.
- W2083436699 hasRelatedWork W2040191638 @default.
- W2083436699 hasRelatedWork W2056385328 @default.
- W2083436699 hasRelatedWork W2220102944 @default.
- W2083436699 hasRelatedWork W2409441623 @default.
- W2083436699 hasRelatedWork W3180719608 @default.
- W2083436699 hasRelatedWork W339756260 @default.
- W2083436699 hasRelatedWork W4210976760 @default.
- W2083436699 hasRelatedWork W1988261318 @default.
- W2083436699 hasRelatedWork W4290123648 @default.