Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083437626> ?p ?o ?g. }
- W2083437626 endingPage "463" @default.
- W2083437626 startingPage "454" @default.
- W2083437626 abstract "Hox genes play important roles in the specification of spatial identity during development of vertebrate embryos. Retinoic acid regulates the transcription of Hox genes in vertebrates. We identified an epidermal enhancer in the 5' flanking region of an ortholog of Hox1 (Ci-Hox1) in the ascidian Ciona intestinalis. This enhancer element drives the transcription of a lacZ reporter gene in the epidermis in the posterior trunk and the anterior tail region of tailbud-stage embryos. Inhibition of retinoic acid synthesis resulted in inactivation of the expression of the reporter gene. The enhancer contains a putative retinoic acid response element. When this element was mutagenized, the expression of the reporter gene disappeared from the epidermis. This sequence was also required for the response to exogenously administered retinoic acid. A heterodimeric nuclear receptor, consisting of the retinoic acid receptor and retinoid X receptor, bound to this sequence. These results indicate that retinoic acid directly activates the epidermal enhancer of Ci-Hox1. This is the first demonstration that retinoic acid is necessary for endogenous gene expression in ascidian embryos." @default.
- W2083437626 created "2016-06-24" @default.
- W2083437626 creator A5032691944 @default.
- W2083437626 creator A5034537316 @default.
- W2083437626 creator A5070743648 @default.
- W2083437626 date "2009-11-01" @default.
- W2083437626 modified "2023-10-16" @default.
- W2083437626 title "Epidermal expression of Hox1 is directly activated by retinoic acid in the Ciona intestinalis embryo" @default.
- W2083437626 cites W1491580744 @default.
- W2083437626 cites W1527331090 @default.
- W2083437626 cites W1634383009 @default.
- W2083437626 cites W1900387077 @default.
- W2083437626 cites W1906119900 @default.
- W2083437626 cites W1965015728 @default.
- W2083437626 cites W1970255608 @default.
- W2083437626 cites W1981292447 @default.
- W2083437626 cites W1994299057 @default.
- W2083437626 cites W1994597456 @default.
- W2083437626 cites W1996306915 @default.
- W2083437626 cites W2004346300 @default.
- W2083437626 cites W2009371644 @default.
- W2083437626 cites W2009414541 @default.
- W2083437626 cites W2010564301 @default.
- W2083437626 cites W2011467252 @default.
- W2083437626 cites W2012345206 @default.
- W2083437626 cites W2019571014 @default.
- W2083437626 cites W2023003508 @default.
- W2083437626 cites W2026665158 @default.
- W2083437626 cites W2027183934 @default.
- W2083437626 cites W2031019063 @default.
- W2083437626 cites W2034071939 @default.
- W2083437626 cites W2035157530 @default.
- W2083437626 cites W2038167511 @default.
- W2083437626 cites W2040050815 @default.
- W2083437626 cites W2040398187 @default.
- W2083437626 cites W2046901241 @default.
- W2083437626 cites W2049588762 @default.
- W2083437626 cites W2056609435 @default.
- W2083437626 cites W2072716955 @default.
- W2083437626 cites W2076877143 @default.
- W2083437626 cites W2077309447 @default.
- W2083437626 cites W2087485172 @default.
- W2083437626 cites W2087916342 @default.
- W2083437626 cites W2092047281 @default.
- W2083437626 cites W2093425338 @default.
- W2083437626 cites W2118374041 @default.
- W2083437626 cites W2122878396 @default.
- W2083437626 cites W2133197725 @default.
- W2083437626 cites W2136942954 @default.
- W2083437626 cites W2141568746 @default.
- W2083437626 cites W2141942684 @default.
- W2083437626 cites W2170258388 @default.
- W2083437626 cites W2181933303 @default.
- W2083437626 cites W2184148586 @default.
- W2083437626 cites W2211286533 @default.
- W2083437626 cites W2403920751 @default.
- W2083437626 doi "https://doi.org/10.1016/j.ydbio.2009.09.027" @default.
- W2083437626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19782671" @default.
- W2083437626 hasPublicationYear "2009" @default.
- W2083437626 type Work @default.
- W2083437626 sameAs 2083437626 @default.
- W2083437626 citedByCount "28" @default.
- W2083437626 countsByYear W20834376262012 @default.
- W2083437626 countsByYear W20834376262013 @default.
- W2083437626 countsByYear W20834376262014 @default.
- W2083437626 countsByYear W20834376262015 @default.
- W2083437626 countsByYear W20834376262016 @default.
- W2083437626 countsByYear W20834376262017 @default.
- W2083437626 countsByYear W20834376262018 @default.
- W2083437626 countsByYear W20834376262019 @default.
- W2083437626 countsByYear W20834376262021 @default.
- W2083437626 crossrefType "journal-article" @default.
- W2083437626 hasAuthorship W2083437626A5032691944 @default.
- W2083437626 hasAuthorship W2083437626A5034537316 @default.
- W2083437626 hasAuthorship W2083437626A5070743648 @default.
- W2083437626 hasBestOaLocation W20834376261 @default.
- W2083437626 hasConcept C104317684 @default.
- W2083437626 hasConcept C111039654 @default.
- W2083437626 hasConcept C111936080 @default.
- W2083437626 hasConcept C119775778 @default.
- W2083437626 hasConcept C120197328 @default.
- W2083437626 hasConcept C139522298 @default.
- W2083437626 hasConcept C150194340 @default.
- W2083437626 hasConcept C153911025 @default.
- W2083437626 hasConcept C161733203 @default.
- W2083437626 hasConcept C162253465 @default.
- W2083437626 hasConcept C19431177 @default.
- W2083437626 hasConcept C2779528156 @default.
- W2083437626 hasConcept C2781121885 @default.
- W2083437626 hasConcept C54355233 @default.
- W2083437626 hasConcept C86339819 @default.
- W2083437626 hasConcept C86803240 @default.
- W2083437626 hasConcept C89364313 @default.
- W2083437626 hasConcept C95444343 @default.
- W2083437626 hasConceptScore W2083437626C104317684 @default.
- W2083437626 hasConceptScore W2083437626C111039654 @default.
- W2083437626 hasConceptScore W2083437626C111936080 @default.
- W2083437626 hasConceptScore W2083437626C119775778 @default.