FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083440158> ?p ?o ?g. }

• W2083440158 endingPage "20991" @default.
• W2083440158 startingPage "20978" @default.
• W2083440158 abstract "Memory formation requires learning-based molecular and structural changes in neurons, whereas matrix metalloproteinase (MMP) 9 is involved in the synaptic plasticity by cleaving extracellular matrix proteins and, thus, is associated with learning processes in the mammalian brain. Because the mechanisms of MMP-9 transcription in the brain are poorly understood, this study aimed to elucidate regulation of MMP-9 gene expression in the mouse brain after fear learning. We show here that contextual fear conditioning markedly increases MMP-9 transcription, followed by enhanced enzymatic levels in the three major brain structures implicated in fear learning, i.e. the amygdala, hippocampus, and prefrontal cortex. To reveal the role of AP-1 transcription factor in MMP-9 gene expression, we have used reporter gene constructs with specifically mutated AP-1 gene promoter sites. The constructs were introduced into the medial prefrontal cortex of neonatal mouse pups by electroporation, and the regulation of MMP-9 transcription was studied after contextual fear conditioning in the adult animals. Specifically, -42/-50- and -478/-486-bp AP-1 binding motifs of the mouse MMP-9 promoter sequence have been found to play a major role in MMP-9 gene activation. Furthermore, increases in MMP-9 gene promoter binding by the AP-1 transcription factor proteins c-Fos and c-Jun have been demonstrated in all three brain structures under investigation. Hence, our results suggest that AP-1 acts as a positive regulator of MMP-9 transcription in the brain following fear learning." @default.
• W2083440158 created "2016-06-24" @default.
• W2083440158 creator A5010975119 @default.
• W2083440158 creator A5014816544 @default.
• W2083440158 creator A5052689587 @default.
• W2083440158 creator A5081808095 @default.
• W2083440158 creator A5084163212 @default.
• W2083440158 creator A5088677160 @default.
• W2083440158 date "2013-07-01" @default.
• W2083440158 modified "2023-10-16" @default.
• W2083440158 title "Matrix Metalloproteinase (MMP) 9 Transcription in Mouse Brain Induced by Fear Learning" @default.
• W2083440158 cites W140013419 @default.
• W2083440158 cites W1488829562 @default.
• W2083440158 cites W1583835478 @default.
• W2083440158 cites W1619234695 @default.
• W2083440158 cites W1706443485 @default.
• W2083440158 cites W1977637789 @default.
• W2083440158 cites W1978053309 @default.
• W2083440158 cites W1984704306 @default.
• W2083440158 cites W1989777389 @default.
• W2083440158 cites W1992146533 @default.
• W2083440158 cites W1995954315 @default.
• W2083440158 cites W1997208014 @default.
• W2083440158 cites W1997218140 @default.
• W2083440158 cites W1998802487 @default.
• W2083440158 cites W2001528712 @default.
• W2083440158 cites W2019507419 @default.
• W2083440158 cites W2024570326 @default.
• W2083440158 cites W2026644728 @default.
• W2083440158 cites W2030320309 @default.
• W2083440158 cites W2042094805 @default.
• W2083440158 cites W2044424240 @default.
• W2083440158 cites W2048047884 @default.
• W2083440158 cites W2050568435 @default.
• W2083440158 cites W2061601835 @default.
• W2083440158 cites W2066977229 @default.
• W2083440158 cites W2068554197 @default.
• W2083440158 cites W2073259535 @default.
• W2083440158 cites W2073357074 @default.
• W2083440158 cites W2080822716 @default.
• W2083440158 cites W2088446997 @default.
• W2083440158 cites W2091187766 @default.
• W2083440158 cites W2093424312 @default.
• W2083440158 cites W2102444756 @default.
• W2083440158 cites W2109213714 @default.
• W2083440158 cites W2117308838 @default.
• W2083440158 cites W2117958894 @default.
• W2083440158 cites W2120495407 @default.
• W2083440158 cites W2123994513 @default.
• W2083440158 cites W2125886581 @default.
• W2083440158 cites W2128049766 @default.
• W2083440158 cites W2132751375 @default.
• W2083440158 cites W2134940624 @default.
• W2083440158 cites W2138347804 @default.
• W2083440158 cites W2154793195 @default.
• W2083440158 cites W2159526401 @default.
• W2083440158 cites W2168383728 @default.
• W2083440158 cites W4232755968 @default.
• W2083440158 cites W4245129714 @default.
• W2083440158 cites W4296759731 @default.
• W2083440158 doi "https://doi.org/10.1074/jbc.m113.457903" @default.
• W2083440158 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3774367" @default.
• W2083440158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23720741" @default.
• W2083440158 hasPublicationYear "2013" @default.
• W2083440158 type Work @default.
• W2083440158 sameAs 2083440158 @default.
• W2083440158 citedByCount "83" @default.
• W2083440158 countsByYear W20834401582013 @default.
• W2083440158 countsByYear W20834401582014 @default.
• W2083440158 countsByYear W20834401582015 @default.
• W2083440158 countsByYear W20834401582016 @default.
• W2083440158 countsByYear W20834401582017 @default.
• W2083440158 countsByYear W20834401582018 @default.
• W2083440158 countsByYear W20834401582019 @default.
• W2083440158 countsByYear W20834401582020 @default.
• W2083440158 countsByYear W20834401582021 @default.
• W2083440158 countsByYear W20834401582022 @default.
• W2083440158 countsByYear W20834401582023 @default.
• W2083440158 crossrefType "journal-article" @default.
• W2083440158 hasAuthorship W2083440158A5010975119 @default.
• W2083440158 hasAuthorship W2083440158A5014816544 @default.
• W2083440158 hasAuthorship W2083440158A5052689587 @default.
• W2083440158 hasAuthorship W2083440158A5081808095 @default.
• W2083440158 hasAuthorship W2083440158A5084163212 @default.
• W2083440158 hasAuthorship W2083440158A5088677160 @default.
• W2083440158 hasBestOaLocation W20834401581 @default.
• W2083440158 hasConcept C101762097 @default.
• W2083440158 hasConcept C104317684 @default.
• W2083440158 hasConcept C138885662 @default.
• W2083440158 hasConcept C150194340 @default.
• W2083440158 hasConcept C165864922 @default.
• W2083440158 hasConcept C16837860 @default.
• W2083440158 hasConcept C169760540 @default.
• W2083440158 hasConcept C169900460 @default.
• W2083440158 hasConcept C179926584 @default.
• W2083440158 hasConcept C2779144063 @default.
• W2083440158 hasConcept C2779555244 @default.
• W2083440158 hasConcept C2781195155 @default.

• next