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• W2083443721 abstract "Therapeutics targeting specific mechanisms of asthma have shown promising results in mouse models of asthma. However, these successes have not transferred well to the clinic or to the treatment of asthma sufferers. We suggest a reason for this incongruity is that mast cell-dependent responses, which may play an important role in the pathogenesis of both atopic and non-atopic asthma, are not a key component in most of the current asthma mouse models. Two reasons for this are that wild type mice have, in contrast to humans, a negligible number of mast cells localized in the smaller airways and in the parenchyma, and that only specific protocols show mast cell-dependent reactions. The development of mast cell-deficient mice and the reconstitution of mast cells within these mice have opened up the possibility to generate mouse models of asthma with a marked role of mast cells. In addition, mast cell-deficient mice engrafted with mast cells have a distribution of mast cells more similar to humans. In this article we review and highlight the mast cell-dependent and -independent responses with respect to airway hyperresponsiveness and inflammation in asthma models using mast cell-deficient and mast cell-engrafted mice." @default.
• W2083443721 created "2016-06-24" @default.
• W2083443721 creator A5003449723 @default.
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• W2083443721 creator A5016859188 @default.
• W2083443721 date "2013-10-01" @default.
• W2083443721 modified "2023-10-17" @default.
• W2083443721 title "Insights into mast cell functions in asthma using mouse models" @default.
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• W2083443721 doi "https://doi.org/10.1016/j.pupt.2013.03.019" @default.
• W2083443721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23583635" @default.
• W2083443721 hasPublicationYear "2013" @default.
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