Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083446822> ?p ?o ?g. }
- W2083446822 endingPage "379" @default.
- W2083446822 startingPage "371" @default.
- W2083446822 abstract "IκBNS regulates a subset of Toll-like receptor (TLR)-dependent genes including interleukin-6 (IL-6) by inhibiting nuclear factor-κB (NF-κB). IL-6 is an inflammatory biomarker for cardiovascular diseases. The aim of this study was to determine whether IκBNS changes arterial inflammation and intimal hyperplasia after vascular injury.We investigated neointimal formation in IκBNS-deficient (IκBNS(-/-); C57BL/6 background) and wild-type (IκBNS(+/+)) mice 2 weeks after cuff injury. The mean intimal area and the intima/media ratio of IκBNS(-/-) mice increased 89% (8066 ± 1141 vs. 4267 ± 1095 μm(2); P = 0.027) and 100% (0.72 ± 0.13 vs. 0.36 ± 0.09; P = 0.032) compared with IκBNS(+/+) mice. We observed significant up-regulation of TLR4 in injured arteries of IκBNS(-/-) mice. NF-κB activity in the intima of IκBNS(-/-) mice was 5.1-fold higher (P = 0.008) compared with IκBNS(+/+) mice at 7 days post-injury. IL-6 mRNA levels in injured arteries of IκBNS(-/-) mice were 1.8-fold higher (P = 0.002) compared with those of IκBNS(+/+) mice at 3 days post-injury. Vascular smooth muscle cells from IκBNS(-/-) mice showed a significant increase in cell migration compared with those from IκBNS(+/+) mice after IL-6 stimulation in the scratch-wound healing assay. Furthermore, anti-mouse IL-6 receptor antibody (MR16-1) significantly reduced intimal hyperplasia compared with control IgG injection in IκBNS(-/-) mice. These findings suggest that IL-6 participates in the development of neointimal hyperplasia after vascular injury in IκBNS(-/-) mice.IκBNS down-regulates TLR4 expression, NF-κB activity, and IL-6 production after vascular injury. IκBNS might suppress intimal hyperplasia caused by vascular inflammation such as atherosclerosis, and restenosis after angioplasty." @default.
- W2083446822 created "2016-06-24" @default.
- W2083446822 creator A5004021508 @default.
- W2083446822 creator A5021463605 @default.
- W2083446822 creator A5029275273 @default.
- W2083446822 creator A5036654496 @default.
- W2083446822 creator A5058894672 @default.
- W2083446822 creator A5065736621 @default.
- W2083446822 creator A5068044071 @default.
- W2083446822 creator A5069084767 @default.
- W2083446822 creator A5076502886 @default.
- W2083446822 date "2011-12-01" @default.
- W2083446822 modified "2023-10-18" @default.
- W2083446822 title "I BNS regulates interleukin-6 production and inhibits neointimal formation after vascular injury in mice" @default.
- W2083446822 cites W1497514376 @default.
- W2083446822 cites W1586229903 @default.
- W2083446822 cites W1965772617 @default.
- W2083446822 cites W1977706612 @default.
- W2083446822 cites W1983068219 @default.
- W2083446822 cites W1984937747 @default.
- W2083446822 cites W1995744610 @default.
- W2083446822 cites W1997215979 @default.
- W2083446822 cites W2001271520 @default.
- W2083446822 cites W2016902297 @default.
- W2083446822 cites W2023647145 @default.
- W2083446822 cites W2037371398 @default.
- W2083446822 cites W2056034929 @default.
- W2083446822 cites W2060780133 @default.
- W2083446822 cites W2066406328 @default.
- W2083446822 cites W2068218731 @default.
- W2083446822 cites W2074284980 @default.
- W2083446822 cites W2086309499 @default.
- W2083446822 cites W2090743807 @default.
- W2083446822 cites W2096014011 @default.
- W2083446822 cites W2098664290 @default.
- W2083446822 cites W2100592123 @default.
- W2083446822 cites W2103403492 @default.
- W2083446822 cites W2112855847 @default.
- W2083446822 cites W2119340324 @default.
- W2083446822 cites W2121718174 @default.
- W2083446822 cites W2134461080 @default.
- W2083446822 cites W2139660685 @default.
- W2083446822 cites W2142340468 @default.
- W2083446822 cites W2145327750 @default.
- W2083446822 cites W2158135412 @default.
- W2083446822 cites W2163139958 @default.
- W2083446822 cites W2324841714 @default.
- W2083446822 cites W4229941561 @default.
- W2083446822 cites W4235745237 @default.
- W2083446822 doi "https://doi.org/10.1093/cvr/cvr323" @default.
- W2083446822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22135163" @default.
- W2083446822 hasPublicationYear "2011" @default.
- W2083446822 type Work @default.
- W2083446822 sameAs 2083446822 @default.
- W2083446822 citedByCount "17" @default.
- W2083446822 countsByYear W20834468222013 @default.
- W2083446822 countsByYear W20834468222014 @default.
- W2083446822 countsByYear W20834468222015 @default.
- W2083446822 countsByYear W20834468222016 @default.
- W2083446822 countsByYear W20834468222017 @default.
- W2083446822 countsByYear W20834468222019 @default.
- W2083446822 countsByYear W20834468222020 @default.
- W2083446822 countsByYear W20834468222022 @default.
- W2083446822 countsByYear W20834468222023 @default.
- W2083446822 crossrefType "journal-article" @default.
- W2083446822 hasAuthorship W2083446822A5004021508 @default.
- W2083446822 hasAuthorship W2083446822A5021463605 @default.
- W2083446822 hasAuthorship W2083446822A5029275273 @default.
- W2083446822 hasAuthorship W2083446822A5036654496 @default.
- W2083446822 hasAuthorship W2083446822A5058894672 @default.
- W2083446822 hasAuthorship W2083446822A5065736621 @default.
- W2083446822 hasAuthorship W2083446822A5068044071 @default.
- W2083446822 hasAuthorship W2083446822A5069084767 @default.
- W2083446822 hasAuthorship W2083446822A5076502886 @default.
- W2083446822 hasBestOaLocation W20834468221 @default.
- W2083446822 hasConcept C134018914 @default.
- W2083446822 hasConcept C142724271 @default.
- W2083446822 hasConcept C203014093 @default.
- W2083446822 hasConcept C2776070231 @default.
- W2083446822 hasConcept C2776914184 @default.
- W2083446822 hasConcept C2777562237 @default.
- W2083446822 hasConcept C2779395532 @default.
- W2083446822 hasConcept C2779751240 @default.
- W2083446822 hasConcept C2992686903 @default.
- W2083446822 hasConcept C71924100 @default.
- W2083446822 hasConceptScore W2083446822C134018914 @default.
- W2083446822 hasConceptScore W2083446822C142724271 @default.
- W2083446822 hasConceptScore W2083446822C203014093 @default.
- W2083446822 hasConceptScore W2083446822C2776070231 @default.
- W2083446822 hasConceptScore W2083446822C2776914184 @default.
- W2083446822 hasConceptScore W2083446822C2777562237 @default.
- W2083446822 hasConceptScore W2083446822C2779395532 @default.
- W2083446822 hasConceptScore W2083446822C2779751240 @default.
- W2083446822 hasConceptScore W2083446822C2992686903 @default.
- W2083446822 hasConceptScore W2083446822C71924100 @default.
- W2083446822 hasIssue "2" @default.
- W2083446822 hasLocation W20834468221 @default.
- W2083446822 hasLocation W20834468222 @default.