FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083457869> ?p ?o ?g. }

• W2083457869 abstract "The morphogenesis of pulmonary injury induced by an impurity present in a commercially important organophosphorus insecticide, O,O,S-trimethyl phosphorothioate (OOS-TMP), was studied by combined light and transmission electron microscopy. Weanling female WAG/Rij rats received OOS-TMP dissolved in corn oil by gavage and were studied at intervals from 6 to 168 h after treatment. Sequestration of neutrophils was initially observed at 12 h after treatment and was accompanied by interstitial oedema. Plasmalemma alterations in endothelium lining capillaries and small arteries and veins were observed from 12 to 120 h after treatment and were accompanied by endothelial cell detachment and separation from the basal lamina. Abundant aggregates of fibrin were sequentially observed in intravascular, interstitial, and alveolar spaces. Platelet aggregation and degranulation were occasionally observed in capillaries as early as 12 h after treatment, and frequently observed in capillaries and small vessels from 24 to 96 h after treatment. Significant increases in wet lung weight and lung water content occurred at the same time that morphologic changes were observed in pulmonary endothelium. Alterations in type I alveolar epithelial cells were initially observed at 24 h after treatment. Cell swelling, fragmentation, and necrosis were observed in both type I and type II cells and resulted in a bare basal lamina. Marked attenuation, hypertrophy, and proliferation of type II epithelial cells followed alveolar epithelial cell injury and loss. Minimal changes were observed in non-ciliated bronchiolar epithelial (Clara) cells; predominant changes included the loss of surface microvilli and apical cytoplasmic bulge. The results of this study indicate that the endothelium and alveolar epithelium are the predominant cell types in the rat lung injured following OOS-TMP administration.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2083457869 created "2016-06-24" @default.
• W2083457869 creator A5034287604 @default.
• W2083457869 creator A5054229306 @default.
• W2083457869 creator A5079256404 @default.
• W2083457869 date "1988-07-01" @default.
• W2083457869 modified "2023-09-23" @default.
• W2083457869 title "Pulmonary endothelial and alveolar epithelial lesions induced byO,O,S-trimethyl phosphorothioate in rats" @default.
• W2083457869 cites W1966178798 @default.
• W2083457869 cites W1968892048 @default.
• W2083457869 cites W1970385846 @default.
• W2083457869 cites W1976236115 @default.
• W2083457869 cites W1976588996 @default.
• W2083457869 cites W1981750321 @default.
• W2083457869 cites W1983001428 @default.
• W2083457869 cites W1993976512 @default.
• W2083457869 cites W1995005422 @default.
• W2083457869 cites W1998679866 @default.
• W2083457869 cites W2014261817 @default.
• W2083457869 cites W2016808790 @default.
• W2083457869 cites W2019388279 @default.
• W2083457869 cites W2033899018 @default.
• W2083457869 cites W2055498031 @default.
• W2083457869 cites W2056103155 @default.
• W2083457869 cites W2089052356 @default.
• W2083457869 cites W2090005133 @default.
• W2083457869 cites W2090924413 @default.
• W2083457869 cites W2094209930 @default.
• W2083457869 cites W2105834903 @default.
• W2083457869 cites W2141113613 @default.
• W2083457869 cites W2335757080 @default.
• W2083457869 cites W2342764320 @default.
• W2083457869 doi "https://doi.org/10.1002/path.1711550311" @default.
• W2083457869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3411385" @default.
• W2083457869 hasPublicationYear "1988" @default.
• W2083457869 type Work @default.
• W2083457869 sameAs 2083457869 @default.
• W2083457869 citedByCount "12" @default.
• W2083457869 countsByYear W20834578692016 @default.
• W2083457869 crossrefType "journal-article" @default.
• W2083457869 hasAuthorship W2083457869A5034287604 @default.
• W2083457869 hasAuthorship W2083457869A5054229306 @default.
• W2083457869 hasAuthorship W2083457869A5079256404 @default.
• W2083457869 hasConcept C105702510 @default.
• W2083457869 hasConcept C123012128 @default.
• W2083457869 hasConcept C126322002 @default.
• W2083457869 hasConcept C134018914 @default.
• W2083457869 hasConcept C142724271 @default.
• W2083457869 hasConcept C185592680 @default.
• W2083457869 hasConcept C202751555 @default.
• W2083457869 hasConcept C2776992346 @default.
• W2083457869 hasConcept C2777714996 @default.
• W2083457869 hasConcept C2779333224 @default.
• W2083457869 hasConcept C2909420118 @default.
• W2083457869 hasConcept C529295009 @default.
• W2083457869 hasConcept C55493867 @default.
• W2083457869 hasConcept C71924100 @default.
• W2083457869 hasConcept C86803240 @default.
• W2083457869 hasConcept C87555872 @default.
• W2083457869 hasConceptScore W2083457869C105702510 @default.
• W2083457869 hasConceptScore W2083457869C123012128 @default.
• W2083457869 hasConceptScore W2083457869C126322002 @default.
• W2083457869 hasConceptScore W2083457869C134018914 @default.
• W2083457869 hasConceptScore W2083457869C142724271 @default.
• W2083457869 hasConceptScore W2083457869C185592680 @default.
• W2083457869 hasConceptScore W2083457869C202751555 @default.
• W2083457869 hasConceptScore W2083457869C2776992346 @default.
• W2083457869 hasConceptScore W2083457869C2777714996 @default.
• W2083457869 hasConceptScore W2083457869C2779333224 @default.
• W2083457869 hasConceptScore W2083457869C2909420118 @default.
• W2083457869 hasConceptScore W2083457869C529295009 @default.
• W2083457869 hasConceptScore W2083457869C55493867 @default.
• W2083457869 hasConceptScore W2083457869C71924100 @default.
• W2083457869 hasConceptScore W2083457869C86803240 @default.
• W2083457869 hasConceptScore W2083457869C87555872 @default.
• W2083457869 hasLocation W20834578691 @default.
• W2083457869 hasLocation W20834578692 @default.
• W2083457869 hasOpenAccess W2083457869 @default.
• W2083457869 hasPrimaryLocation W20834578691 @default.
• W2083457869 hasRelatedWork W1966843303 @default.
• W2083457869 hasRelatedWork W1981626910 @default.
• W2083457869 hasRelatedWork W1998058741 @default.
• W2083457869 hasRelatedWork W2024472168 @default.
• W2083457869 hasRelatedWork W2074530197 @default.
• W2083457869 hasRelatedWork W2081831421 @default.
• W2083457869 hasRelatedWork W2083312306 @default.
• W2083457869 hasRelatedWork W2129363868 @default.
• W2083457869 hasRelatedWork W2143598529 @default.
• W2083457869 hasRelatedWork W2460430048 @default.
• W2083457869 isParatext "false" @default.
• W2083457869 isRetracted "false" @default.
• W2083457869 magId "2083457869" @default.
• W2083457869 workType "article" @default.