FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083462015> ?p ?o ?g. }

• W2083462015 endingPage "1008" @default.
• W2083462015 startingPage "1006" @default.
• W2083462015 abstract "This cross-sectional study examined 1,096 midlife women, associating menopausal symptoms, including hot flashes, vaginal dryness, sore joints, incontinence, irritability, mood changes, and headache, with quality of life (QOL), as measured using Cantril’s Ladder of Life. The results showed that low QOL may be significantly associated with feeling tense and mood changes, but not the other selected symptoms. This cross-sectional study examined 1,096 midlife women, associating menopausal symptoms, including hot flashes, vaginal dryness, sore joints, incontinence, irritability, mood changes, and headache, with quality of life (QOL), as measured using Cantril’s Ladder of Life. The results showed that low QOL may be significantly associated with feeling tense and mood changes, but not the other selected symptoms. Researchers estimate that more than a million women in the United States will reach the menopausal transition each year (1Joffe H. Soares C.N. Cohen L.S. Assessment and treatment of hot flushes and menopausal mood disturbance.Psychiatr Clin North Am. 2003; 26: 563-580Abstract Full Text Full Text PDF PubMed Scopus (61) Google Scholar). A variety of physical and psychologic symptoms are commonly experienced during the menopausal transition, including vasomotor disturbances (hot flashes and night sweats), insomnia, depression, lability of mood, headache, memory loss, and decreased libido (2Whiteman M.K. Staropoli C.A. Langenberg P.W. McCarter R.J. Kjerulff K.H. Flaws J.A. Smoking, body mass, and hot flashes in midlife women.Obstet Gynecol. 2003; 101: 264-272Crossref PubMed Scopus (174) Google Scholar, 3Senanayake P. Women and reproductive health in a graying world.Int J Gynaecol Obstet. 2000; 70: 59-67Abstract Full Text Full Text PDF PubMed Scopus (17) Google Scholar, 4Whiteman M.K. Staropoli C.A. Benedict J.C. Borgeest C. Flaws J.A. Risk factors for hot flashes in midlife women.J Womens Health. 2003; 12: 459-472Crossref Scopus (101) Google Scholar). These symptoms affect approximately 40%–70% of all midlife women (2Whiteman M.K. Staropoli C.A. Langenberg P.W. McCarter R.J. Kjerulff K.H. Flaws J.A. Smoking, body mass, and hot flashes in midlife women.Obstet Gynecol. 2003; 101: 264-272Crossref PubMed Scopus (174) Google Scholar, 3Senanayake P. Women and reproductive health in a graying world.Int J Gynaecol Obstet. 2000; 70: 59-67Abstract Full Text Full Text PDF PubMed Scopus (17) Google Scholar, 4Whiteman M.K. Staropoli C.A. Benedict J.C. Borgeest C. Flaws J.A. Risk factors for hot flashes in midlife women.J Womens Health. 2003; 12: 459-472Crossref Scopus (101) Google Scholar, 5Schwingl P.J. Hulka B.S. Harlow S.D. Risk factors for menopausal hot flashes.Obstet Gynecol. 1994; 84: 29-34PubMed Google Scholar) and lead to innumerable physician visits with a cost to society in the billions of dollars (6Utian W.H. Psychosocial and socioeconomic burden of vasomotor symptoms in menopause: a comprehensive review.Health Qual Life Outcomes. 2005; 3: 47Crossref PubMed Scopus (272) Google Scholar). With the average life expectancy continuing to rise, quality of life (QOL) is increasingly considered to be an important parameter of health for the aging population (3Senanayake P. Women and reproductive health in a graying world.Int J Gynaecol Obstet. 2000; 70: 59-67Abstract Full Text Full Text PDF PubMed Scopus (17) Google Scholar, 6Utian W.H. Psychosocial and socioeconomic burden of vasomotor symptoms in menopause: a comprehensive review.Health Qual Life Outcomes. 2005; 3: 47Crossref PubMed Scopus (272) Google Scholar). Few studies, however, have examined which treatable menopausal symptoms are independently associated with QOL during the menopausal transition. The majority of the studies examining an association between menopausal symptoms and QOL have been limited in the number and type of symptoms that have been evaluated. Further, among studies that have reported on similar symptoms, findings have been inconsistent (7Dennerstein L. Dudley E. Burger H. Well-being and the menopausal transition.J Psychosom Obstet Gynecol. 1997; 18: 95-101Crossref PubMed Scopus (42) Google Scholar, 8Li S. Holm K. Gulanick M. Lanuza D. Perimenopause and the quality of life.Clin Nurs Res. 2000; 9: 6-26PubMed Google Scholar). Because of the inconsistency of published results and the limited number of reports on menopausal symptoms other than vasomotor symptoms, little information is available on which to base targeted interventions. In this study, we used Cantril’s Self-Anchoring Ladder of Life (9Cantril H. The pattern of human concerns. Rutgers University Press, New Brunswick, NJ1965Google Scholar), a validated measure of overall life satisfaction in which responses range from 1 to 10, to examine which of 12 menopausal symptoms were independently associated with QOL in a cross-sectional sample of midlife women. Data were collected from 1,129 women aged 40 to 60 living in the Baltimore metropolitan region who reported their menopausal status, history of menopausal symptoms, QOL, and other information through a mailed survey as previously described (2Whiteman M.K. Staropoli C.A. Langenberg P.W. McCarter R.J. Kjerulff K.H. Flaws J.A. Smoking, body mass, and hot flashes in midlife women.Obstet Gynecol. 2003; 101: 264-272Crossref PubMed Scopus (174) Google Scholar, 10Whiteman M.K. Miller K.P. Tomic D. Langenberg P. Flaws J.A. Tubal ligation and hot flashes.Fertil Steril. 2004; 82: 502-504Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar). The 15-page questionnaire took 15 to 25 minutes to complete and asked questions regarding demographics, reproductive history, use of hormone therapy or oral contraception, general medical and family history, and lifestyle behaviors, including smoking and alcohol use. The questionnaire also obtained information about QOL and menopausal symptoms. The study was approved by the Institutional Review Board at the University of Maryland. Menopausal status was categorized as premenopausal, perimenopausal, and postmenopausal as described by Whiteman et al. (2Whiteman M.K. Staropoli C.A. Langenberg P.W. McCarter R.J. Kjerulff K.H. Flaws J.A. Smoking, body mass, and hot flashes in midlife women.Obstet Gynecol. 2003; 101: 264-272Crossref PubMed Scopus (174) Google Scholar). The experiencing of menopausal symptoms was assessed using questions that ascertained whether the woman had experienced the symptom within the previous 2 weeks and the frequency with which she suffered from the symptom over the previous 2 weeks (not at all, 1–5 days, 6–8 days, 9–13 days, or every day). The symptoms queried included hot flashes, cold sweats, vaginal dryness, dizziness, feeling tense, forgetfulness, incontinence, headache, irritability, mood changes, stiff neck, and stiffness in joint. QOL was examined as the main outcome variable. Because the distribution of the QOL responses was skewed, the QOL data were grouped into three categories for ordinal logistic regression analyses based on the distribution of the data. The three categories of QOL were as follows: “low,” QOL score of 1–6; “average,” QOL score of 7–8; and “high,” QOL score of 9–10. Of the 1,129 women who completed and returned questionnaires, 33 were excluded from this analysis because of missing data. Specifically, 12 women were missing data on QOL and 22 subjects were missing data on menopausal status (1 woman was missing data on both). Thus, a total of 1,096 women were included in the final analysis for this study. Overall, 78.1% of the participants were of white race and 56.2% were postmenopausal. Most of the women in the study sample had a high school degree, were married or living with a partner, and were employed. Further, most of the women in the sample reported never smoking and being in good or excellent health. Menopausal status was not significantly associated with QOL (data not shown). However, among all of the women, experiencing any one of the menopausal symptoms aside from hot flashes was significantly associated with a lower QOL score in the univariate analyses (Table 1). When all of the menopausal symptoms were included in the regression model, headache, mood changes, and feeling tense were significantly associated with low QOL (Table 1, Model 1). After further adjustment for age, self-reported health, diagnosis of depression, education, race, marital status, employment, having a sexual partner, smoking, and current hormone therapy use, mood changes and feeling tense remained significantly associated with low QOL (Table 1, Model 2). Hot flashes, cold sweats, vaginal dryness, dizziness, forgetfulness, headache, incontinence, and stiff neck or joints were not independently associated with low QOL in either model.TABLE 1Association of menopausal symptoms with quality of life (QOL) in univariate analysis and low QOL in multivariable ordinal logistic regression analyses.Menopausal symptomsnMean QOL score (SD)Model 1,aIndividual symptom odds ratio adjusted for other menopausal symptoms listed in Table. odds ratio (95% CI)Model 2,bIndividual symptom odds ratio adjusted for other menopausal symptoms listed in Table and age, self-reported health, diagnosis of depression, education, marital status, employment, smoking, and current hormone therapy or oral contraceptive use. odds ratio (95% CI)Hot flashes No4857.6 (1.7)1.00 (reference)1.00 (reference) Yes6107.5 (1.8)1.04 (0.81, 1.34)0.94 (0.69, 1.27)Cold sweatscP<.05 in univariate analysis of variance procedures. No9087.6 (1.7)1.00 (reference)1.00 (reference) Yes1147.1 (2.0)1.12 (0.77, 1.63)0.93 (0.63, 1.39)Vaginal drynesscP<.05 in univariate analysis of variance procedures. No7547.7 (1.7)1.00 (reference)1.00 (reference) Yes2957.3 (1.8)1.16 (0.88, 1.53)1.26 (0.94, 1.69)DizzinesscP<.05 in univariate analysis of variance procedures. No8377.7 (1.7)1.00 (reference)1.00 (reference) Yes2157.1 (2.0)1.30 (0.95, 1.79)1.09 (0.78, 1.53)Feeling tensecP<.05 in univariate analysis of variance procedures. No3858.1 (1.6)1.00 (reference)1.00 (reference) Yes6727.3 (1.8)1.58 (1.18, 2.10)1.52 (1.12, 2.07)ForgetfulnesscP<.05 in univariate analysis of variance procedures. No4157.9 (1.5)1.00 (reference)1.00 (reference) Yes6537.3 (1.9)1.16 (0.88, 1.52)1.20 (0.89, 1.61)IncontinencecP<.05 in univariate analysis of variance procedures. No6957.7 (1.7)1.00 (reference)1.00 (reference) Yes3677.3 (1.8)1.14 (0.88, 1.49)1.07 (0.80, 1.41)HeadachecP<.05 in univariate analysis of variance procedures. No4567.9 (1.6)1.00 (reference)1.00 (reference) Yes6157.3 (1.8)1.37 (1.06, 1.77)1.31 (0.99, 1.72)IrritabilitycP<.05 in univariate analysis of variance procedures. No4118.0 (1.5)1.00 (reference)1.00 (reference) Yes6467.3 (1.8)1.16 (0.86, 1.58)1.25 (0.91, 1.73)Mood changescP<.05 in univariate analysis of variance procedures. No5558.0 (1.5)1.00 (reference)1.00 (reference) Yes5017.1 (1.9)1.52 (1.13, 2.05)1.42 (1.03, 1.95)Stiff neckcP<.05 in univariate analysis of variance procedures. No4247.8 (1.7)1.00 (reference)1.00 (reference) Yes6407.4 (1.8)0.99 (0.76, 1.30)0.89 (0.67, 1.18)Stiffness, other jointscP<.05 in univariate analysis of variance procedures. No3517.8 (1.6)1.00 (reference)1.00 (reference) Yes7117.4 (1.8)1.00 (0.75, 1.32)0.91 (0.67, 1.22)Bankowski. Menopausal symptoms and quality of life. Fertil Steril 2006.a Individual symptom odds ratio adjusted for other menopausal symptoms listed in Table.b Individual symptom odds ratio adjusted for other menopausal symptoms listed in Table and age, self-reported health, diagnosis of depression, education, marital status, employment, smoking, and current hormone therapy or oral contraceptive use.c P<.05 in univariate analysis of variance procedures. Open table in a new tab Bankowski. Menopausal symptoms and quality of life. Fertil Steril 2006. The results of this cross-sectional survey of midlife women suggest that feeling tense and mood changes are associated with a low QOL independent of other menopausal symptoms, including hot flashes and joint pain, and other characteristics such as self-reported health. These results are not surprising because findings from several previous studies suggest that psychosomatic symptoms such as mood changes and feeling tense may be a more important determinant of QOL than vasomotor symptoms during the menopausal transition (8Li S. Holm K. Gulanick M. Lanuza D. Perimenopause and the quality of life.Clin Nurs Res. 2000; 9: 6-26PubMed Google Scholar, 11Boulet M.J. Oddens B.J. Lehert P. Vemer H.M. Visser A. Climacteric and menopause in seven south-east Asian countries.Maturitas. 1994; 19: 157-176Abstract Full Text PDF PubMed Scopus (294) Google Scholar). Some researchers have suggested that psychosomatic symptoms may reflect current life events and personal difficulties, such as decline of sexual function, an ailing spouse or parent, marital disharmony, or movement of children out of the home, rather than menopausal status (8Li S. Holm K. Gulanick M. Lanuza D. Perimenopause and the quality of life.Clin Nurs Res. 2000; 9: 6-26PubMed Google Scholar). If this is the case, identifying midlife women who experience the most severe personal difficulties for behavioral interventions, such as psychologic counseling, may help to alleviate psychosomatic symptoms and resulting reductions in QOL. In contrast, it is also possible that the experiencing of psychosomatic symptoms during perimenopause is due to biologic changes within a woman’s body, such as an imbalance in the levels of neurotransmitters of the gamma-aminobutyric acid and serotonin systems (8Li S. Holm K. Gulanick M. Lanuza D. Perimenopause and the quality of life.Clin Nurs Res. 2000; 9: 6-26PubMed Google Scholar). If the experiencing of psychosomatic symptoms is truly a result of biologic changes, maintaining balance within the serotonin system through medications may result in alleviation of bothersome psychosomatic symptoms. Interestingly, in this study, we observed that self-reported QOL was not associated with menopausal status. Some, but not all, previous studies have reported lower QOL or well-being during perimenopause and have suggested that this is due to the experiencing of menopausal symptoms (7Dennerstein L. Dudley E. Burger H. Well-being and the menopausal transition.J Psychosom Obstet Gynecol. 1997; 18: 95-101Crossref PubMed Scopus (42) Google Scholar, 12Groeneveld F.P. Bareman F.P. Barentsen R. Dokter H.J. Drogendijk A.C. Hoes A.W. Vasomotor symptoms and well-being in the climacteric years.Maturitas. 1996; 23: 293-299Abstract Full Text PDF PubMed Scopus (33) Google Scholar). In this study, a higher frequency of both perimenopausal and postmenopausal women reported experiencing each of the symptoms that were examined in this study. Moreover, women who were perimenopausal or postmenopausal reported experiencing a significantly greater number of symptoms than the premenopausal women in this sample. It may be that the perimenopausal and postmenopausal women who responded to our survey were, in general, more tolerant of the menopausal symptoms and, perhaps, were experiencing less severe symptoms. Therefore, these women may have had a better QOL overall than the general population of women who are undergoing or who have undergone the menopausal transition. Future study is needed to investigate the optimal strategies to evaluate and treat psychosomatic symptoms in the midlife period. Further work should address differences in clinical situations and treatments between ethnicities and cultures to illuminate particular domains of women’s lives that impact their quality of life. As we gain a greater understanding of the menopausal transition, emphasis should be placed on using our wide armamentarium of therapeutic approaches to target particular symptoms to have the greatest effect to improve women’s quality of life." @default.
• W2083462015 created "2016-06-24" @default.
• W2083462015 creator A5023232025 @default.
• W2083462015 creator A5030970287 @default.
• W2083462015 creator A5040540252 @default.
• W2083462015 creator A5040949438 @default.
• W2083462015 creator A5045794217 @default.
• W2083462015 creator A5062024086 @default.
• W2083462015 date "2006-10-01" @default.
• W2083462015 modified "2023-10-03" @default.
• W2083462015 title "The association between menopausal symptoms and quality of life in midlife women" @default.
• W2083462015 cites W1975296576 @default.
• W2083462015 cites W2000066513 @default.
• W2083462015 cites W2004668568 @default.
• W2083462015 cites W2007012878 @default.
• W2083462015 cites W2075124549 @default.
• W2083462015 cites W2086198131 @default.
• W2083462015 cites W2135256516 @default.
• W2083462015 cites W2150127964 @default.
• W2083462015 cites W4246369984 @default.
• W2083462015 doi "https://doi.org/10.1016/j.fertnstert.2006.03.031" @default.
• W2083462015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16962115" @default.
• W2083462015 hasPublicationYear "2006" @default.
• W2083462015 type Work @default.
• W2083462015 sameAs 2083462015 @default.
• W2083462015 citedByCount "15" @default.
• W2083462015 countsByYear W20834620152012 @default.
• W2083462015 countsByYear W20834620152013 @default.
• W2083462015 countsByYear W20834620152014 @default.
• W2083462015 countsByYear W20834620152015 @default.
• W2083462015 countsByYear W20834620152016 @default.
• W2083462015 countsByYear W20834620152022 @default.
• W2083462015 crossrefType "journal-article" @default.
• W2083462015 hasAuthorship W2083462015A5023232025 @default.
• W2083462015 hasAuthorship W2083462015A5030970287 @default.
• W2083462015 hasAuthorship W2083462015A5040540252 @default.
• W2083462015 hasAuthorship W2083462015A5040949438 @default.
• W2083462015 hasAuthorship W2083462015A5045794217 @default.
• W2083462015 hasAuthorship W2083462015A5062024086 @default.
• W2083462015 hasBestOaLocation W20834620151 @default.
• W2083462015 hasConcept C142853389 @default.
• W2083462015 hasConcept C144024400 @default.
• W2083462015 hasConcept C149923435 @default.
• W2083462015 hasConcept C15744967 @default.
• W2083462015 hasConcept C2779951463 @default.
• W2083462015 hasConcept C29456083 @default.
• W2083462015 hasConcept C542102704 @default.
• W2083462015 hasConcept C71924100 @default.
• W2083462015 hasConcept C74909509 @default.
• W2083462015 hasConceptScore W2083462015C142853389 @default.
• W2083462015 hasConceptScore W2083462015C144024400 @default.
• W2083462015 hasConceptScore W2083462015C149923435 @default.
• W2083462015 hasConceptScore W2083462015C15744967 @default.
• W2083462015 hasConceptScore W2083462015C2779951463 @default.
• W2083462015 hasConceptScore W2083462015C29456083 @default.
• W2083462015 hasConceptScore W2083462015C542102704 @default.
• W2083462015 hasConceptScore W2083462015C71924100 @default.
• W2083462015 hasConceptScore W2083462015C74909509 @default.
• W2083462015 hasIssue "4" @default.
• W2083462015 hasLocation W20834620151 @default.
• W2083462015 hasLocation W20834620152 @default.
• W2083462015 hasOpenAccess W2083462015 @default.
• W2083462015 hasPrimaryLocation W20834620151 @default.
• W2083462015 hasRelatedWork W2024166604 @default.
• W2083462015 hasRelatedWork W2062852819 @default.
• W2083462015 hasRelatedWork W2107258778 @default.
• W2083462015 hasRelatedWork W2298482518 @default.
• W2083462015 hasRelatedWork W2339531101 @default.
• W2083462015 hasRelatedWork W2515067198 @default.
• W2083462015 hasRelatedWork W2731674637 @default.
• W2083462015 hasRelatedWork W2748952813 @default.
• W2083462015 hasRelatedWork W2899084033 @default.
• W2083462015 hasRelatedWork W51496479 @default.
• W2083462015 hasVolume "86" @default.
• W2083462015 isParatext "false" @default.
• W2083462015 isRetracted "false" @default.
• W2083462015 magId "2083462015" @default.
• W2083462015 workType "article" @default.