Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083463199> ?p ?o ?g. }
- W2083463199 endingPage "154" @default.
- W2083463199 startingPage "147" @default.
- W2083463199 abstract "Abstract Hypoxic‐ischemic brain damage (HIBD), a leading cause of perinatal disability and death, has limited therapeutic options. Stem cell therapy has been demonstrated as a potential novel therapy for neurological disorders. Compared with other types of stem cells, umbilical cord blood mesenchymal stem cells (UCB‐MSCs) have several unique characteristics, such as a higher rate of cell proliferation and clonality. However, the limited life span of UCB‐MSCs hinders their clinical application. Therefore, efforts are urgently needed to circumvent this disadvantage. Telomerase reverse transcriptase (TERT), which promotes cell proliferation and survival, plays a protective role in hypoxic‐ischemic (HI) brain injury. Thus, it is reasonable to propose that UCB‐MSCs modified by exogenous TERT expression might have a longer lifespan and increased viability. Moreover, brain‐derived neurotrophic factor (BDNF), a neurotrophin that regulates development, regeneration, survival and maintenance of neurons, facilitates post‐injury recovery when administered by infusion or virus‐mediated delivery. Therefore, TERT‐ and BDNF‐modified UCB‐MSCs may have a longer lifespan and also maintain neural differentiation, thus promoting the recovery of neurological function following hypoxic‐ischemic brain damage (HIBD) and thereby representing a new effective strategy for HIBD in neonates." @default.
- W2083463199 created "2016-06-24" @default.
- W2083463199 creator A5011982092 @default.
- W2083463199 creator A5029801393 @default.
- W2083463199 creator A5054896880 @default.
- W2083463199 creator A5056073315 @default.
- W2083463199 creator A5065769386 @default.
- W2083463199 date "2014-07-03" @default.
- W2083463199 modified "2023-10-15" @default.
- W2083463199 title "Umbilical cord blood mesenchymal stem cells co‐modified by TERT and BDNF: A novel neuroprotective therapy for neonatal hypoxic‐ischemic brain damage" @default.
- W2083463199 cites W1488813153 @default.
- W2083463199 cites W1600543929 @default.
- W2083463199 cites W1751954544 @default.
- W2083463199 cites W1823665952 @default.
- W2083463199 cites W1852458835 @default.
- W2083463199 cites W1964184187 @default.
- W2083463199 cites W1965617341 @default.
- W2083463199 cites W1966087162 @default.
- W2083463199 cites W1966486881 @default.
- W2083463199 cites W1966841015 @default.
- W2083463199 cites W1967033957 @default.
- W2083463199 cites W1967114216 @default.
- W2083463199 cites W1967435113 @default.
- W2083463199 cites W1975682269 @default.
- W2083463199 cites W1976021029 @default.
- W2083463199 cites W1977750724 @default.
- W2083463199 cites W1979612822 @default.
- W2083463199 cites W1980336239 @default.
- W2083463199 cites W1980424869 @default.
- W2083463199 cites W1983827575 @default.
- W2083463199 cites W1984506820 @default.
- W2083463199 cites W1990742974 @default.
- W2083463199 cites W1995926433 @default.
- W2083463199 cites W1997123576 @default.
- W2083463199 cites W2009448733 @default.
- W2083463199 cites W2011732277 @default.
- W2083463199 cites W2012561426 @default.
- W2083463199 cites W2014423429 @default.
- W2083463199 cites W2015013686 @default.
- W2083463199 cites W2015051853 @default.
- W2083463199 cites W2015262351 @default.
- W2083463199 cites W2015362019 @default.
- W2083463199 cites W2016631367 @default.
- W2083463199 cites W2016995671 @default.
- W2083463199 cites W2017112248 @default.
- W2083463199 cites W2023316079 @default.
- W2083463199 cites W2024210866 @default.
- W2083463199 cites W2025791374 @default.
- W2083463199 cites W2026713050 @default.
- W2083463199 cites W2032388214 @default.
- W2083463199 cites W2033027472 @default.
- W2083463199 cites W2038157352 @default.
- W2083463199 cites W2040381138 @default.
- W2083463199 cites W2041019678 @default.
- W2083463199 cites W2041802584 @default.
- W2083463199 cites W2048339036 @default.
- W2083463199 cites W2050555938 @default.
- W2083463199 cites W2051448098 @default.
- W2083463199 cites W2056040676 @default.
- W2083463199 cites W2058387425 @default.
- W2083463199 cites W2059819643 @default.
- W2083463199 cites W2062040648 @default.
- W2083463199 cites W2062380006 @default.
- W2083463199 cites W2065544304 @default.
- W2083463199 cites W2069735923 @default.
- W2083463199 cites W2070860656 @default.
- W2083463199 cites W2071746963 @default.
- W2083463199 cites W2076258288 @default.
- W2083463199 cites W2080082408 @default.
- W2083463199 cites W2081168739 @default.
- W2083463199 cites W2081331892 @default.
- W2083463199 cites W2081878966 @default.
- W2083463199 cites W2082173871 @default.
- W2083463199 cites W2083994698 @default.
- W2083463199 cites W2084498863 @default.
- W2083463199 cites W2086545698 @default.
- W2083463199 cites W2090983815 @default.
- W2083463199 cites W2091198832 @default.
- W2083463199 cites W2091919125 @default.
- W2083463199 cites W2092325185 @default.
- W2083463199 cites W2093377304 @default.
- W2083463199 cites W2093789515 @default.
- W2083463199 cites W2094544368 @default.
- W2083463199 cites W2096180958 @default.
- W2083463199 cites W2099498580 @default.
- W2083463199 cites W2105801231 @default.
- W2083463199 cites W2107087596 @default.
- W2083463199 cites W2109951202 @default.
- W2083463199 cites W2111149177 @default.
- W2083463199 cites W2114099339 @default.
- W2083463199 cites W2114446851 @default.
- W2083463199 cites W2116081750 @default.
- W2083463199 cites W2116813871 @default.
- W2083463199 cites W2118423764 @default.
- W2083463199 cites W2121670270 @default.
- W2083463199 cites W2122899692 @default.
- W2083463199 cites W2123919647 @default.
- W2083463199 cites W2137600062 @default.