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- W2083465006 abstract "Fibrinogen adsorbed on material surfaces undergoes conformational changes that expose the platelet binding epitope located in the gamma-chain dodecapeptide. Circulating blood platelets bind to this exposed region, leading to platelet adhesion and activation, eventually forming a surface-induced thrombus. We have developed an AFM technique utilizing an antibody-modified probe that allows us to calculate the probability of this epitope being available following fibrinogen adsorption to solid surfaces, and have shown that the time-dependent changes in this probability of antibody binding correlate with temporal changes in platelet adhesion to materials. Recently, we have begun to explore how well this probability of adhesion correlates to platelet adhesion across a variety of different polymeric biomaterials. Results demonstrate that there is a strong relationship between this probability and measured platelet adhesion for 3 different homopolymer materials (figure 1), but two different phase-separated polyurethane (PU) materials possessing heterogeneous surface chemistries appear to deviate from this probability/adhesion relationship. These results suggest that the ∼50 to 100 nm sized phases in PU materials may affect the ability of platelets to bind to fibrinogen in a manner that leads to the improved blood compatibility seen with PU materials.View Large Image | View Hi-Res Image | Download PowerPoint Slide" @default.
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- W2083465006 date "2012-01-01" @default.
- W2083465006 modified "2023-09-28" @default.
- W2083465006 title "Effects of Biomaterial Chemical Heterogeneity on Fibrinogen Activity-Platelet Adhesion Relationships" @default.
- W2083465006 doi "https://doi.org/10.1016/j.bpj.2011.11.3883" @default.
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