FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083465863> ?p ?o ?g. }

• W2083465863 endingPage "59" @default.
• W2083465863 startingPage "51" @default.
• W2083465863 abstract "A 2071-bp DNA fragment, containing a gene (lys1) encoding a protein that showed 71.1% identical amino acids with the Yarrowia lipolytica homocitrate synthase and 71.7% identity with the Saccharomyces cerevisiae homologous enzyme, was cloned from a genomic library of Penicillium chrysogenum. The lys1 gene contained three introns and encoded a protein of 474 amino acids with a deduced molecular mass of 52 kDa. lys1 was located in chromosome II (9.6 Mb) in the wild-type P. chrysogenum NRRL 1951, whereas it hybridized with chromosome III (7.5 Mb) in the high penicillin production strain AS-P-78. The lys1 gene is transcribed as a monocistronic transcript of 2.0 kb. Levels of the lys1 transcript were high in P. chrysogenum Wis 54–1255 cultures in defined penicillin production medium at 24 and 48 h, coinciding with the rapid growth phase, but clearly decreased during the penicillin production phase, suggesting that α-aminoadipic acid formation for penicillin biosynthesis may be limited at the homocitrate synthase level. Expression of lys1 was partially repressed by high concentrations of lysine in the culture medium, but lysine repression seems to be a weak mechanism of control of the lysine pathway as compared to lysine inhibition of homocitrate synthase." @default.
• W2083465863 created "2016-06-24" @default.
• W2083465863 creator A5018899140 @default.
• W2083465863 creator A5019891152 @default.
• W2083465863 creator A5061222660 @default.
• W2083465863 creator A5071784570 @default.
• W2083465863 creator A5075426691 @default.
• W2083465863 creator A5077467718 @default.
• W2083465863 date "1999-01-01" @default.
• W2083465863 modified "2023-09-23" @default.
• W2083465863 title "Characterization and lysine control of expression of the lys1 gene of Penicillium chrysogenum encoding homocitrate synthase" @default.
• W2083465863 cites W1273387433 @default.
• W2083465863 cites W1524986936 @default.
• W2083465863 cites W1551076656 @default.
• W2083465863 cites W1568037618 @default.
• W2083465863 cites W1580408986 @default.
• W2083465863 cites W1704706975 @default.
• W2083465863 cites W1733154868 @default.
• W2083465863 cites W1815019682 @default.
• W2083465863 cites W1918792962 @default.
• W2083465863 cites W1977819162 @default.
• W2083465863 cites W1981132422 @default.
• W2083465863 cites W1990073542 @default.
• W2083465863 cites W1992689612 @default.
• W2083465863 cites W1995232418 @default.
• W2083465863 cites W2000374491 @default.
• W2083465863 cites W2005474936 @default.
• W2083465863 cites W200845854 @default.
• W2083465863 cites W2024828771 @default.
• W2083465863 cites W2025955941 @default.
• W2083465863 cites W2032462421 @default.
• W2083465863 cites W2033905101 @default.
• W2083465863 cites W2039704790 @default.
• W2083465863 cites W2042179571 @default.
• W2083465863 cites W2079910536 @default.
• W2083465863 cites W2080416549 @default.
• W2083465863 cites W2081499792 @default.
• W2083465863 cites W2099462729 @default.
• W2083465863 cites W2100861681 @default.
• W2083465863 cites W2111561341 @default.
• W2083465863 cites W2125398207 @default.
• W2083465863 cites W2129779495 @default.
• W2083465863 cites W2135967789 @default.
• W2083465863 cites W2138270253 @default.
• W2083465863 cites W2198958677 @default.
• W2083465863 cites W2227494418 @default.
• W2083465863 cites W2237827975 @default.
• W2083465863 cites W4301360785 @default.
• W2083465863 cites W6509195 @default.
• W2083465863 cites W73225049 @default.
• W2083465863 doi "https://doi.org/10.1016/s0378-1119(98)00551-4" @default.
• W2083465863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9889317" @default.
• W2083465863 hasPublicationYear "1999" @default.
• W2083465863 type Work @default.
• W2083465863 sameAs 2083465863 @default.
• W2083465863 citedByCount "21" @default.
• W2083465863 countsByYear W20834658632012 @default.
• W2083465863 countsByYear W20834658632014 @default.
• W2083465863 countsByYear W20834658632020 @default.
• W2083465863 countsByYear W20834658632023 @default.
• W2083465863 crossrefType "journal-article" @default.
• W2083465863 hasAuthorship W2083465863A5018899140 @default.
• W2083465863 hasAuthorship W2083465863A5019891152 @default.
• W2083465863 hasAuthorship W2083465863A5061222660 @default.
• W2083465863 hasAuthorship W2083465863A5071784570 @default.
• W2083465863 hasAuthorship W2083465863A5075426691 @default.
• W2083465863 hasAuthorship W2083465863A5077467718 @default.
• W2083465863 hasConcept C104317684 @default.
• W2083465863 hasConcept C153911025 @default.
• W2083465863 hasConcept C2776016237 @default.
• W2083465863 hasConcept C2777270571 @default.
• W2083465863 hasConcept C515207424 @default.
• W2083465863 hasConcept C55493867 @default.
• W2083465863 hasConcept C86803240 @default.
• W2083465863 hasConceptScore W2083465863C104317684 @default.
• W2083465863 hasConceptScore W2083465863C153911025 @default.
• W2083465863 hasConceptScore W2083465863C2776016237 @default.
• W2083465863 hasConceptScore W2083465863C2777270571 @default.
• W2083465863 hasConceptScore W2083465863C515207424 @default.
• W2083465863 hasConceptScore W2083465863C55493867 @default.
• W2083465863 hasConceptScore W2083465863C86803240 @default.
• W2083465863 hasIssue "1" @default.
• W2083465863 hasLocation W20834658631 @default.
• W2083465863 hasLocation W20834658632 @default.
• W2083465863 hasOpenAccess W2083465863 @default.
• W2083465863 hasPrimaryLocation W20834658631 @default.
• W2083465863 hasRelatedWork W1594530831 @default.
• W2083465863 hasRelatedWork W1918792962 @default.
• W2083465863 hasRelatedWork W2009966535 @default.
• W2083465863 hasRelatedWork W2039704790 @default.
• W2083465863 hasRelatedWork W2056895342 @default.
• W2083465863 hasRelatedWork W2081940762 @default.
• W2083465863 hasRelatedWork W2093059412 @default.
• W2083465863 hasRelatedWork W2125398207 @default.
• W2083465863 hasRelatedWork W2171277769 @default.
• W2083465863 hasRelatedWork W2415312109 @default.
• W2083465863 hasVolume "226" @default.
• W2083465863 isParatext "false" @default.

• next