Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083466039> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2083466039 endingPage "S52" @default.
- W2083466039 startingPage "S52" @default.
- W2083466039 abstract "75 The mechanisms underlying enhanced myogenic contraction (MC) in coronary resistance arteries isolated from exercise-trained (ET) pigs are unknown. The purpose of this study was to test the hypothesis that ET-induced adaptations in protein kinase C (PKC) signaling underlie enhanced MC. Male Yucatan miniature swine (n=7) trained 75% of VO2max for 16 weeks (6 mph, 10% grade, 60 min) or remained sedentary (SED; n=6). Vasoreactivity was evaluated in cannulated resistance arteries (100 μm) in response to intraluminal pressure (60, 75, 90 cmH2O) or potassium chloride (KCL; 60 mM) with and without the PKC blocker chelerythrine (CE; 10 μM). Diameter measurements were expressed relative to passive diameter (after 100 μM sodium nitroprusside). CE elicited greater reductions in MC in ET vs SED (p<0.01). At 90 cmH2O, CE decreased MC by 44% vs 25% in ET and SED, respectively (p<0.01). KCL constriction was also less in ET vs SED (18% vs 34%; p<0.01). Western blotting revealed significant increases in PKC-α but not PKC-∊ levels in resistance arteries isolated from ET. Interestingly, voltage-gated Ca2+ current was blocked by CE in cells isolated from resistance arteries. These data suggest that PKC-dependent effects on MC are greater in resistance arteries isolated from ET. These data further suggest that effects on MC may be mediated, at least in part, by ET effects on PKC-dependent modulation of voltage-gated Ca2+ channels. (Supported by NIH grants PO1-HL-52490 and T32-HD-07460-04)." @default.
- W2083466039 created "2016-06-24" @default.
- W2083466039 creator A5004527252 @default.
- W2083466039 creator A5024602587 @default.
- W2083466039 creator A5025227099 @default.
- W2083466039 creator A5037673510 @default.
- W2083466039 date "1999-05-01" @default.
- W2083466039 modified "2023-09-26" @default.
- W2083466039 title "ENHANCED MYOGENIC CONTRACTION BY EXERCISE TRAINING IN PORCINE CORONARY RESISTANCE ARTERIES IS MEDIATED BY PKC-DEPENDENT MECHANISMS" @default.
- W2083466039 doi "https://doi.org/10.1097/00005768-199905001-00075" @default.
- W2083466039 hasPublicationYear "1999" @default.
- W2083466039 type Work @default.
- W2083466039 sameAs 2083466039 @default.
- W2083466039 citedByCount "3" @default.
- W2083466039 countsByYear W20834660392015 @default.
- W2083466039 crossrefType "journal-article" @default.
- W2083466039 hasAuthorship W2083466039A5004527252 @default.
- W2083466039 hasAuthorship W2083466039A5024602587 @default.
- W2083466039 hasAuthorship W2083466039A5025227099 @default.
- W2083466039 hasAuthorship W2083466039A5037673510 @default.
- W2083466039 hasBestOaLocation W20834660391 @default.
- W2083466039 hasConcept C126322002 @default.
- W2083466039 hasConcept C126707884 @default.
- W2083466039 hasConcept C134018914 @default.
- W2083466039 hasConcept C163415756 @default.
- W2083466039 hasConcept C164705383 @default.
- W2083466039 hasConcept C174940676 @default.
- W2083466039 hasConcept C184235292 @default.
- W2083466039 hasConcept C185592680 @default.
- W2083466039 hasConcept C195794163 @default.
- W2083466039 hasConcept C2776108454 @default.
- W2083466039 hasConcept C2776820930 @default.
- W2083466039 hasConcept C2778742706 @default.
- W2083466039 hasConcept C2779395532 @default.
- W2083466039 hasConcept C2779610285 @default.
- W2083466039 hasConcept C2779961880 @default.
- W2083466039 hasConcept C2992686903 @default.
- W2083466039 hasConcept C519581460 @default.
- W2083466039 hasConcept C55493867 @default.
- W2083466039 hasConcept C58245268 @default.
- W2083466039 hasConcept C58336856 @default.
- W2083466039 hasConcept C71924100 @default.
- W2083466039 hasConcept C72859922 @default.
- W2083466039 hasConcept C84393581 @default.
- W2083466039 hasConceptScore W2083466039C126322002 @default.
- W2083466039 hasConceptScore W2083466039C126707884 @default.
- W2083466039 hasConceptScore W2083466039C134018914 @default.
- W2083466039 hasConceptScore W2083466039C163415756 @default.
- W2083466039 hasConceptScore W2083466039C164705383 @default.
- W2083466039 hasConceptScore W2083466039C174940676 @default.
- W2083466039 hasConceptScore W2083466039C184235292 @default.
- W2083466039 hasConceptScore W2083466039C185592680 @default.
- W2083466039 hasConceptScore W2083466039C195794163 @default.
- W2083466039 hasConceptScore W2083466039C2776108454 @default.
- W2083466039 hasConceptScore W2083466039C2776820930 @default.
- W2083466039 hasConceptScore W2083466039C2778742706 @default.
- W2083466039 hasConceptScore W2083466039C2779395532 @default.
- W2083466039 hasConceptScore W2083466039C2779610285 @default.
- W2083466039 hasConceptScore W2083466039C2779961880 @default.
- W2083466039 hasConceptScore W2083466039C2992686903 @default.
- W2083466039 hasConceptScore W2083466039C519581460 @default.
- W2083466039 hasConceptScore W2083466039C55493867 @default.
- W2083466039 hasConceptScore W2083466039C58245268 @default.
- W2083466039 hasConceptScore W2083466039C58336856 @default.
- W2083466039 hasConceptScore W2083466039C71924100 @default.
- W2083466039 hasConceptScore W2083466039C72859922 @default.
- W2083466039 hasConceptScore W2083466039C84393581 @default.
- W2083466039 hasIssue "Supplement" @default.
- W2083466039 hasLocation W20834660391 @default.
- W2083466039 hasLocation W20834660392 @default.
- W2083466039 hasOpenAccess W2083466039 @default.
- W2083466039 hasPrimaryLocation W20834660391 @default.
- W2083466039 hasRelatedWork W1967851866 @default.
- W2083466039 hasRelatedWork W1972653373 @default.
- W2083466039 hasRelatedWork W2008016552 @default.
- W2083466039 hasRelatedWork W2100588235 @default.
- W2083466039 hasRelatedWork W2340864374 @default.
- W2083466039 hasRelatedWork W2395477385 @default.
- W2083466039 hasRelatedWork W2417344859 @default.
- W2083466039 hasRelatedWork W4296312527 @default.
- W2083466039 hasRelatedWork W966309862 @default.
- W2083466039 hasRelatedWork W2498419824 @default.
- W2083466039 hasVolume "31" @default.
- W2083466039 isParatext "false" @default.
- W2083466039 isRetracted "false" @default.
- W2083466039 magId "2083466039" @default.
- W2083466039 workType "article" @default.