FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083466960> ?p ?o ?g. }

• W2083466960 endingPage "878" @default.
• W2083466960 startingPage "870" @default.
• W2083466960 abstract "OBJECTIVE To determine the early effects of oestrogen on the ultrastructure of the pudendal nerve and distal nerve fascicles near the external urethra sphincter (EUS) after a pudendal nerve crush injury. The pudendal nerve is one of the pelvic floor tissues injured during vaginal delivery, possibly contributing to the development of stress urinary incontinence (SUI) in women, the symptoms of which often do not appear until menopause, implicating hormonal factors. MATERIALS AND METHODS Twenty‐seven virgin female Sprague‐Dawley rats were anaesthetized and underwent ovariectomy. Three days later, they had one of four procedures: bilateral pudendal nerve crush plus implant of a subcutaneous oestrogen‐containing capsule (NC+E); nerve crush plus implant of a sham saline‐containing capsule (NC+S); no nerve crush with an oestrogen capsule; or no nerve crush with a sham capsule. After 2 weeks the pudendal nerves and urethral tissues were prepared for light and electron microscopy. The number of axons, myelin figures and endoneurial nuclei in the pudendal nerve segment distal to the lesion were counted. Nerve fascicles near the EUS were also counted and categorized as normal or showing signs of degeneration and/or regeneration. The location of each nerve fascicle was specified as either ventral or dorsal. RESULTS As there were no significant differences between the two control groups they were combined to form a single control group. In the distal pudendal nerve there were significantly fewer myelinated axons and large myelinated axons in the NC+E and NC+S groups than in the control group. There were three times as many large unmyelinated axons in the NC+E group than in either the NC+S or control groups ( P < 0.05). There were only half as many nerve fascicles near the ventral side of the EUS in the NC+S group than in both the control and NC+E groups ( P < 0.05). CONCLUSION Oestrogen appears to affect large unmyelinated axons in both the injured pudendal nerve and at the denervated EUS target. After pudendal nerve crush, nerve fascicles with evidence of degeneration or regeneration near the EUS appear to be spared with oestrogen treatment, particularly in the ventral region. These observations may reflect the early stages of a neuroregenerative effect of oestrogen. Additional studies are needed to confirm these results at later periods and with functional methods." @default.
• W2083466960 created "2016-06-24" @default.
• W2083466960 creator A5002082077 @default.
• W2083466960 creator A5017579123 @default.
• W2083466960 creator A5036588955 @default.
• W2083466960 creator A5039524414 @default.
• W2083466960 date "2004-03-25" @default.
• W2083466960 modified "2023-10-17" @default.
• W2083466960 title "Early structural effects of oestrogen on pudendal nerve regeneration in the rat" @default.
• W2083466960 cites W130612560 @default.
• W2083466960 cites W142080826 @default.
• W2083466960 cites W1485329507 @default.
• W2083466960 cites W1498065596 @default.
• W2083466960 cites W1973920492 @default.
• W2083466960 cites W1985601572 @default.
• W2083466960 cites W1994025114 @default.
• W2083466960 cites W1994855240 @default.
• W2083466960 cites W2002879969 @default.
• W2083466960 cites W2007980908 @default.
• W2083466960 cites W2008055766 @default.
• W2083466960 cites W2012291650 @default.
• W2083466960 cites W2016494506 @default.
• W2083466960 cites W2025923976 @default.
• W2083466960 cites W2027567588 @default.
• W2083466960 cites W2028498492 @default.
• W2083466960 cites W2030983661 @default.
• W2083466960 cites W2032336982 @default.
• W2083466960 cites W2042053041 @default.
• W2083466960 cites W2045548034 @default.
• W2083466960 cites W2049144045 @default.
• W2083466960 cites W2050130404 @default.
• W2083466960 cites W2056203425 @default.
• W2083466960 cites W2060107042 @default.
• W2083466960 cites W2064057862 @default.
• W2083466960 cites W2069100127 @default.
• W2083466960 cites W2075071484 @default.
• W2083466960 cites W2077191174 @default.
• W2083466960 cites W2077554611 @default.
• W2083466960 cites W2078430845 @default.
• W2083466960 cites W2079241211 @default.
• W2083466960 cites W2086158683 @default.
• W2083466960 cites W2086891220 @default.
• W2083466960 cites W2093917662 @default.
• W2083466960 cites W2095008783 @default.
• W2083466960 cites W2096210867 @default.
• W2083466960 cites W2108031357 @default.
• W2083466960 cites W2119504151 @default.
• W2083466960 cites W2125231862 @default.
• W2083466960 cites W2146313494 @default.
• W2083466960 cites W2401012573 @default.
• W2083466960 cites W2426096478 @default.
• W2083466960 cites W2444541437 @default.
• W2083466960 cites W39364382 @default.
• W2083466960 cites W4229848480 @default.
• W2083466960 cites W4293154522 @default.
• W2083466960 doi "https://doi.org/10.1111/j.1464-410x.2003.04792.x" @default.
• W2083466960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15050008" @default.
• W2083466960 hasPublicationYear "2004" @default.
• W2083466960 type Work @default.
• W2083466960 sameAs 2083466960 @default.
• W2083466960 citedByCount "25" @default.
• W2083466960 countsByYear W20834669602012 @default.
• W2083466960 countsByYear W20834669602014 @default.
• W2083466960 countsByYear W20834669602016 @default.
• W2083466960 countsByYear W20834669602020 @default.
• W2083466960 countsByYear W20834669602022 @default.
• W2083466960 countsByYear W20834669602023 @default.
• W2083466960 crossrefType "journal-article" @default.
• W2083466960 hasAuthorship W2083466960A5002082077 @default.
• W2083466960 hasAuthorship W2083466960A5017579123 @default.
• W2083466960 hasAuthorship W2083466960A5036588955 @default.
• W2083466960 hasAuthorship W2083466960A5039524414 @default.
• W2083466960 hasConcept C105702510 @default.
• W2083466960 hasConcept C141071460 @default.
• W2083466960 hasConcept C2777085111 @default.
• W2083466960 hasConcept C2777107032 @default.
• W2083466960 hasConcept C2778778583 @default.
• W2083466960 hasConcept C2780682423 @default.
• W2083466960 hasConcept C2781411149 @default.
• W2083466960 hasConcept C59822182 @default.
• W2083466960 hasConcept C71924100 @default.
• W2083466960 hasConcept C86803240 @default.
• W2083466960 hasConcept C88537330 @default.
• W2083466960 hasConceptScore W2083466960C105702510 @default.
• W2083466960 hasConceptScore W2083466960C141071460 @default.
• W2083466960 hasConceptScore W2083466960C2777085111 @default.
• W2083466960 hasConceptScore W2083466960C2777107032 @default.
• W2083466960 hasConceptScore W2083466960C2778778583 @default.
• W2083466960 hasConceptScore W2083466960C2780682423 @default.
• W2083466960 hasConceptScore W2083466960C2781411149 @default.
• W2083466960 hasConceptScore W2083466960C59822182 @default.
• W2083466960 hasConceptScore W2083466960C71924100 @default.
• W2083466960 hasConceptScore W2083466960C86803240 @default.
• W2083466960 hasConceptScore W2083466960C88537330 @default.
• W2083466960 hasIssue "6" @default.
• W2083466960 hasLocation W20834669601 @default.
• W2083466960 hasLocation W20834669602 @default.
• W2083466960 hasOpenAccess W2083466960 @default.

• next