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- W2083467900 abstract "Background: The biologically active component of a hormone is the unbound or free fraction. Changes in cortisol-binding protein could give misleading results if only total cortisol is measured for the interpretation of dynamic function tests. Methods: This study aimed to measure serum free cortisol using a steady-state gel-filtration method and then to evaluate the correlation between the serum free cortisol and the free cortisol index (FCI), defined as serum total cortisol/cortisol-binding globulin (CBG). Results: Forty-eight serum samples from healthy volunteers undergoing a short Synacthen test were analysed for total cortisol, free cortisol and CBG. The FCI correlated well with a previously established, but more complex, calculation of serum free cortisol ( R = 0·98, P <0·001) and with measured serum free cortisol ( R = 0·90, P < 0·001). Conclusion: Free cortisol index is a reliable and user-friendly measure of serum free cortisol." @default.
- W2083467900 created "2016-06-24" @default.
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- W2083467900 date "2002-07-01" @default.
- W2083467900 modified "2023-10-09" @default.
- W2083467900 title "Free cortisol index as a surrogate marker for serum free cortisol" @default.
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- W2083467900 doi "https://doi.org/10.1258/000456302760042182" @default.
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