Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083467937> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2083467937 endingPage "1111" @default.
- W2083467937 startingPage "1101" @default.
- W2083467937 abstract "The aim of the present study was to commence a characterisation of some of the basic pharmacological properties of venom from the soldierfish ( Gymnapistes marmoratus ). Soldierfish venom was prepared by extraction into 10% glycerol and centrifugation to remove insoluble material. Protein content was determined and venom concentrations were expressed as μg venom protein. Soldierfish venom (0.5–15 μg/ml) produced concentration-dependent contractile responses in guinea-pig isolated ileum (GPI) and longitudinal smooth muscle (LSM) preparations. The muscarinic receptor antagonist atropine (10 nM) significantly inhibited responses of LSM to soldierfish venom (2.5 μg/ml). Responses to soldierfish venom (4–5 μg/ml) in GPI were not significantly affected by the ganglion-blocking drug mecamylamine (10 μM) or by incubation with blood cholinesterase. The cyclooxygenase inhibitor indomethacin (2 μM) significantly inhibited responses to soldierfish venom (2.5 μg/ml) in LSM. Neither the thromboxane A 2 /prostaglandin H 2 receptor antagonist GR32191B (1 μM) nor the leukotriene receptor antagonist SB205312 (10 nM) significantly affected responses to soldierfish venom (5 μg/ml) in GPI. Responses to soldierfish venom (2.5-5 μg/ml) were not significantly inhibited by the histamine receptor antagonist mepyramine (0.5 μM), the angiotensin-converting enzyme inhibitor captopril (2 μM) or the neurokinin-1 receptor antagonist CP-99,994 (0.1 μM) in LSM. The angiotensin AT 1 receptor antagonist EXP3174 (0.1 μM) also failed to inhibit significantly the responses to soldierfish venom (5 μg/ml) in GPI. A fluorometric assay for the detection of 5-hydroxytryptamine (5-HT) and related compounds indicated a level in soldierfish venom of 1.60 ± 0.01 ng of 5-HT-like substance per μg venom protein. Soldierfish venom (0.5–10 μg/ml) produced concentration-dependent contractile responses in rat isolated stomach fundus strips, and these responses (2.5 μg/ml) were significantly inhibited by the 5-HT 1 5-HT 2 receptor antagonist methysergide (0.1 μM). These results suggest that soldierfish venom may stimulate the release of acetylcholine to act at muscarinic receptors on guinea-pig gastrointestinal smooth muscle. The venom also appears to be causing the release of cyclooxygenase products, such as prostaglandins, and contains 5-HT, or a 5-HT-like substance, that acts directly at 5-HT receptors." @default.
- W2083467937 created "2016-06-24" @default.
- W2083467937 creator A5040849398 @default.
- W2083467937 creator A5041003152 @default.
- W2083467937 creator A5064326411 @default.
- W2083467937 date "1997-07-01" @default.
- W2083467937 modified "2023-10-16" @default.
- W2083467937 title "An in vitro pharmacological examination of venom from the soldierfish gymnapistes marmoratus" @default.
- W2083467937 cites W1496403520 @default.
- W2083467937 cites W1939653974 @default.
- W2083467937 cites W1985980835 @default.
- W2083467937 cites W1990070700 @default.
- W2083467937 cites W2020231880 @default.
- W2083467937 cites W2021311015 @default.
- W2083467937 cites W2028836971 @default.
- W2083467937 cites W2036934442 @default.
- W2083467937 cites W2046029794 @default.
- W2083467937 cites W2056283267 @default.
- W2083467937 cites W2074274023 @default.
- W2083467937 cites W2128635872 @default.
- W2083467937 cites W2395627450 @default.
- W2083467937 cites W2421597719 @default.
- W2083467937 cites W2426661946 @default.
- W2083467937 cites W2767264184 @default.
- W2083467937 doi "https://doi.org/10.1016/s0041-0101(96)00213-9" @default.
- W2083467937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9248008" @default.
- W2083467937 hasPublicationYear "1997" @default.
- W2083467937 type Work @default.
- W2083467937 sameAs 2083467937 @default.
- W2083467937 citedByCount "14" @default.
- W2083467937 countsByYear W20834679372015 @default.
- W2083467937 countsByYear W20834679372016 @default.
- W2083467937 countsByYear W20834679372020 @default.
- W2083467937 crossrefType "journal-article" @default.
- W2083467937 hasAuthorship W2083467937A5040849398 @default.
- W2083467937 hasAuthorship W2083467937A5041003152 @default.
- W2083467937 hasAuthorship W2083467937A5064326411 @default.
- W2083467937 hasConcept C1122143 @default.
- W2083467937 hasConcept C170493617 @default.
- W2083467937 hasConcept C185592680 @default.
- W2083467937 hasConcept C2776885963 @default.
- W2083467937 hasConcept C2778122271 @default.
- W2083467937 hasConcept C2779090179 @default.
- W2083467937 hasConcept C2779448229 @default.
- W2083467937 hasConcept C55493867 @default.
- W2083467937 hasConcept C86803240 @default.
- W2083467937 hasConcept C98274493 @default.
- W2083467937 hasConceptScore W2083467937C1122143 @default.
- W2083467937 hasConceptScore W2083467937C170493617 @default.
- W2083467937 hasConceptScore W2083467937C185592680 @default.
- W2083467937 hasConceptScore W2083467937C2776885963 @default.
- W2083467937 hasConceptScore W2083467937C2778122271 @default.
- W2083467937 hasConceptScore W2083467937C2779090179 @default.
- W2083467937 hasConceptScore W2083467937C2779448229 @default.
- W2083467937 hasConceptScore W2083467937C55493867 @default.
- W2083467937 hasConceptScore W2083467937C86803240 @default.
- W2083467937 hasConceptScore W2083467937C98274493 @default.
- W2083467937 hasIssue "7" @default.
- W2083467937 hasLocation W20834679371 @default.
- W2083467937 hasLocation W20834679372 @default.
- W2083467937 hasOpenAccess W2083467937 @default.
- W2083467937 hasPrimaryLocation W20834679371 @default.
- W2083467937 hasRelatedWork W1970028894 @default.
- W2083467937 hasRelatedWork W1988331001 @default.
- W2083467937 hasRelatedWork W2002313556 @default.
- W2083467937 hasRelatedWork W2002314697 @default.
- W2083467937 hasRelatedWork W2047267473 @default.
- W2083467937 hasRelatedWork W2078342627 @default.
- W2083467937 hasRelatedWork W2242618686 @default.
- W2083467937 hasRelatedWork W2398319461 @default.
- W2083467937 hasRelatedWork W2412057469 @default.
- W2083467937 hasRelatedWork W165475594 @default.
- W2083467937 hasVolume "35" @default.
- W2083467937 isParatext "false" @default.
- W2083467937 isRetracted "false" @default.
- W2083467937 magId "2083467937" @default.
- W2083467937 workType "article" @default.