Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083470764> ?p ?o ?g. }
- W2083470764 endingPage "286" @default.
- W2083470764 startingPage "278" @default.
- W2083470764 abstract "The mechanisms for the different proarrhythmic potential of antiarrhythmic drugs in the presence of comparable QT prolongation are not completely understood. The reasons for the lower proarrhythmic potential of amiodarone as compared with other class-III antiarrhythmic drugs such as sotalol, a fact that has been well established for years, is insufficiently known. Therefore, the aim of our study was to assess the different electrophysiologic effects of amiodarone and sotalol in a previously developed experimental model of proarrhythmia. In eight male rabbits, amiodarone (280-340 mg/d) was fed over a period of six weeks. Hearts were excised and retrogradely perfused. Up to eight simultaneous epi- and endocardial monophasic action potentials (MAP) were recorded. Results were compared with sotalol-treated (10-50-100 microM) hearts (n = 13). Amiodarone and sotalol (50 microM and 100 microM) led to a significant increase in QT interval (mean increase: amiodarone: 31 +/- 6 ms; sotalol: 41 +/- 4 ms and 61 +/- 9 ms) and MAP-duration (mean increase-MAP90: amiodarone: 20 +/- 5 ms; sotalol: 17 +/- 5 ms and 25 +/- 8 ms) (P < 0.01). In bradycardic (AV-blocked) hearts, MAP-recordings demonstrated reverse-use dependence and a significant increase in dispersion of repolarization (MAP90) in the presence of sotalol (P < 0.01), but not in amiodarone-treated hearts (10%; p = ns). Sotalol led to early afterdepolarizations (EAD) and torsade de pointes (TdP) after lowering of potassium concentration (6 of 13 hearts). In amiodarone-treated, hypokalemic hearts, no EAD or TdP occurred. Sotalol changed the MAP configuration to a triangular pattern (ratio-MAP90/50: 1.52 as compared with 1.36 at baseline) whereas amiodarone caused a rectangular pattern of MAP prolongation (ratio-MAP90/50: 1.36). In conclusion, these results show no direct correlation between the occurrence of TdP and the degree of QT prolongation. Several factors including reverse-use dependence, dispersion of repolarization, and the propensity to induce early afterdepolarizations but also differences in the action potential configuration may help to understand proarrhythmic side effects of drugs." @default.
- W2083470764 created "2016-06-24" @default.
- W2083470764 creator A5007851719 @default.
- W2083470764 creator A5029898297 @default.
- W2083470764 creator A5033620690 @default.
- W2083470764 creator A5036147033 @default.
- W2083470764 creator A5068593789 @default.
- W2083470764 creator A5079013897 @default.
- W2083470764 creator A5080895047 @default.
- W2083470764 creator A5086140235 @default.
- W2083470764 date "2004-09-01" @default.
- W2083470764 modified "2023-10-08" @default.
- W2083470764 title "Comparison of the In Vitro Electrophysiologic and Proarrhythmic Effects of Amiodarone and Sotalol in a Rabbit Model of Acute Atrioventricular Block" @default.
- W2083470764 cites W1484642847 @default.
- W2083470764 cites W1575021701 @default.
- W2083470764 cites W1965681659 @default.
- W2083470764 cites W1967151871 @default.
- W2083470764 cites W1975869151 @default.
- W2083470764 cites W1980240868 @default.
- W2083470764 cites W1982121419 @default.
- W2083470764 cites W1982762147 @default.
- W2083470764 cites W1997871210 @default.
- W2083470764 cites W2002711428 @default.
- W2083470764 cites W2005534939 @default.
- W2083470764 cites W2013973612 @default.
- W2083470764 cites W2015744609 @default.
- W2083470764 cites W2020900154 @default.
- W2083470764 cites W2022777362 @default.
- W2083470764 cites W2034800157 @default.
- W2083470764 cites W2037470056 @default.
- W2083470764 cites W2038031676 @default.
- W2083470764 cites W2053397482 @default.
- W2083470764 cites W2057257908 @default.
- W2083470764 cites W2065572778 @default.
- W2083470764 cites W2068112205 @default.
- W2083470764 cites W2075751878 @default.
- W2083470764 cites W2076845323 @default.
- W2083470764 cites W2078754141 @default.
- W2083470764 cites W2088806653 @default.
- W2083470764 cites W2100819109 @default.
- W2083470764 cites W2143518969 @default.
- W2083470764 cites W2149059176 @default.
- W2083470764 cites W2156953901 @default.
- W2083470764 cites W2159496782 @default.
- W2083470764 cites W2166807056 @default.
- W2083470764 cites W2171708115 @default.
- W2083470764 cites W2174038367 @default.
- W2083470764 cites W2322423167 @default.
- W2083470764 cites W2334835878 @default.
- W2083470764 doi "https://doi.org/10.1097/01.fjc.0000129581.81508.78" @default.
- W2083470764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15475823" @default.
- W2083470764 hasPublicationYear "2004" @default.
- W2083470764 type Work @default.
- W2083470764 sameAs 2083470764 @default.
- W2083470764 citedByCount "75" @default.
- W2083470764 countsByYear W20834707642012 @default.
- W2083470764 countsByYear W20834707642013 @default.
- W2083470764 countsByYear W20834707642014 @default.
- W2083470764 countsByYear W20834707642015 @default.
- W2083470764 countsByYear W20834707642016 @default.
- W2083470764 countsByYear W20834707642017 @default.
- W2083470764 countsByYear W20834707642018 @default.
- W2083470764 countsByYear W20834707642019 @default.
- W2083470764 countsByYear W20834707642020 @default.
- W2083470764 countsByYear W20834707642022 @default.
- W2083470764 countsByYear W20834707642023 @default.
- W2083470764 crossrefType "journal-article" @default.
- W2083470764 hasAuthorship W2083470764A5007851719 @default.
- W2083470764 hasAuthorship W2083470764A5029898297 @default.
- W2083470764 hasAuthorship W2083470764A5033620690 @default.
- W2083470764 hasAuthorship W2083470764A5036147033 @default.
- W2083470764 hasAuthorship W2083470764A5068593789 @default.
- W2083470764 hasAuthorship W2083470764A5079013897 @default.
- W2083470764 hasAuthorship W2083470764A5080895047 @default.
- W2083470764 hasAuthorship W2083470764A5086140235 @default.
- W2083470764 hasBestOaLocation W20834707641 @default.
- W2083470764 hasConcept C118441451 @default.
- W2083470764 hasConcept C126322002 @default.
- W2083470764 hasConcept C146403970 @default.
- W2083470764 hasConcept C155730078 @default.
- W2083470764 hasConcept C164705383 @default.
- W2083470764 hasConcept C185263204 @default.
- W2083470764 hasConcept C2776639339 @default.
- W2083470764 hasConcept C2777008848 @default.
- W2083470764 hasConcept C2778094803 @default.
- W2083470764 hasConcept C2778131192 @default.
- W2083470764 hasConcept C2779161974 @default.
- W2083470764 hasConcept C2780074459 @default.
- W2083470764 hasConcept C2780486423 @default.
- W2083470764 hasConcept C42219234 @default.
- W2083470764 hasConcept C71924100 @default.
- W2083470764 hasConceptScore W2083470764C118441451 @default.
- W2083470764 hasConceptScore W2083470764C126322002 @default.
- W2083470764 hasConceptScore W2083470764C146403970 @default.
- W2083470764 hasConceptScore W2083470764C155730078 @default.
- W2083470764 hasConceptScore W2083470764C164705383 @default.
- W2083470764 hasConceptScore W2083470764C185263204 @default.
- W2083470764 hasConceptScore W2083470764C2776639339 @default.