FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083480768> ?p ?o ?g. }

• W2083480768 endingPage "603" @default.
• W2083480768 startingPage "591" @default.
• W2083480768 abstract "Characteristics of M Cells. Introduction: Recent studies have described the existence of M cells in the deep structures of the canine and human ventricle. The present study was designed to further characterize the M cell with respect to its distribution across the canine left ventricular free wall and the dependence of its action potential on [K+]0. Methods and Results: We used standard microelectrode techniques to record transmembrane activity from deep subepicardial or transmural strips isolated from the canine left ventricular free wall near the base as well as subendocardial Purkinje fibers. M cell behavior (steep APD-rate relation) was observed at depths of 1 to 7 mm from the epicardial surface (deep subepicardium to mid-myocardium). M cells were found to be distributed uniformly in the deep subepicardium and did not appear in discrete bundles. We observed transitional behavior throughout the wall. The maximum rate of rise of the action potential upstroke, Vmax, increased sharply between epicardium and deep subepicardium (176 ± 13 to 332 ± 61 V/sec), remained high throughout the mid-myocardium and deep subendocardium, and returned to lower values only in the superficial layers of the endocardium (205 ± 21 V/sec). The relationship between Vmax and takeoff potential in the M cell was fit by a Boltzmann equation with a V V0.5 of -68.6 ± 1.5 mV and k of 3.4 ± 0.5. The relationship between resting membrane potential (RMP) and [K+]0 in the M cell was exponential from 8 to 20 mmol/L (58 mV change in RMP per 10-fold change in [K+]0), deviating from K+ electrode behavior at [K+]0, < 8 mmol/L. RMP in M cells continued to hyperpolarize at [K+]0 < 2.5 mmol/L, reaching potentials of approximately -110 mV at I+]0, of 1 mmol/L. In contrast, subendocardial Purkinje fibers depolarized at these low levels of [K+]0. Unlike endocardium and epicardium, M cells developed early afterdepolarizations at low [K+]0 and slow rates. Conclusions: Our data indicate that the M cells are widely distributed in the intramural layers of the canine left ventricular free wall. M cells and transitional cells occupy 30% to 40% of the left ventricular wall and an estimated 20% to 40% of the mass of the ventricles of the normal canine heart. They display characteristics common to both myocardial and specialized conducting cells. Like Purkinje fibers, M cells exhibit a relatively large Vmax and steep APD-rute relations that are modulated by [K+]0. Unlike Purkinje fibers, M cells do not appear in bundles, they do not depolarize at [K+]0 < 2.5 mmol/L, nor do they exhibit phase 4 depolarization." @default.
• W2083480768 created "2016-06-24" @default.
• W2083480768 creator A5005749391 @default.
• W2083480768 creator A5024166075 @default.
• W2083480768 date "1995-08-01" @default.
• W2083480768 modified "2023-10-16" @default.
• W2083480768 title "Electrophysiologic Characteristics of M Cells in the Canine Left Ventricular Free Wall" @default.
• W2083480768 cites W1606576717 @default.
• W2083480768 cites W1967794787 @default.
• W2083480768 cites W1973729956 @default.
• W2083480768 cites W1981757294 @default.
• W2083480768 cites W1982246451 @default.
• W2083480768 cites W1988498011 @default.
• W2083480768 cites W1990267496 @default.
• W2083480768 cites W1997472615 @default.
• W2083480768 cites W2002596889 @default.
• W2083480768 cites W2011670149 @default.
• W2083480768 cites W2028300810 @default.
• W2083480768 cites W2043451457 @default.
• W2083480768 cites W2048591406 @default.
• W2083480768 cites W2050699386 @default.
• W2083480768 cites W2055166534 @default.
• W2083480768 cites W2062629038 @default.
• W2083480768 cites W2063000438 @default.
• W2083480768 cites W2071293796 @default.
• W2083480768 cites W2076076711 @default.
• W2083480768 cites W2080811832 @default.
• W2083480768 cites W2094615122 @default.
• W2083480768 cites W2102943126 @default.
• W2083480768 cites W2105677812 @default.
• W2083480768 cites W2108327352 @default.
• W2083480768 cites W2117765582 @default.
• W2083480768 cites W2121614682 @default.
• W2083480768 cites W2123189713 @default.
• W2083480768 cites W2126578506 @default.
• W2083480768 cites W2128592964 @default.
• W2083480768 cites W2133576088 @default.
• W2083480768 cites W2135225379 @default.
• W2083480768 cites W2136463260 @default.
• W2083480768 cites W2136634569 @default.
• W2083480768 cites W2136653489 @default.
• W2083480768 cites W2142618720 @default.
• W2083480768 cites W2149462844 @default.
• W2083480768 doi "https://doi.org/10.1111/j.1540-8167.1995.tb00435.x" @default.
• W2083480768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8535556" @default.
• W2083480768 hasPublicationYear "1995" @default.
• W2083480768 type Work @default.
• W2083480768 sameAs 2083480768 @default.
• W2083480768 citedByCount "94" @default.
• W2083480768 countsByYear W20834807682012 @default.
• W2083480768 countsByYear W20834807682013 @default.
• W2083480768 countsByYear W20834807682014 @default.
• W2083480768 countsByYear W20834807682015 @default.
• W2083480768 countsByYear W20834807682016 @default.
• W2083480768 countsByYear W20834807682017 @default.
• W2083480768 countsByYear W20834807682018 @default.
• W2083480768 countsByYear W20834807682019 @default.
• W2083480768 crossrefType "journal-article" @default.
• W2083480768 hasAuthorship W2083480768A5005749391 @default.
• W2083480768 hasAuthorship W2083480768A5024166075 @default.
• W2083480768 hasConcept C105702510 @default.
• W2083480768 hasConcept C12554922 @default.
• W2083480768 hasConcept C126322002 @default.
• W2083480768 hasConcept C164705383 @default.
• W2083480768 hasConcept C185263204 @default.
• W2083480768 hasConcept C2777463368 @default.
• W2083480768 hasConcept C2778875491 @default.
• W2083480768 hasConcept C2778921608 @default.
• W2083480768 hasConcept C71924100 @default.
• W2083480768 hasConcept C85378888 @default.
• W2083480768 hasConcept C86803240 @default.
• W2083480768 hasConceptScore W2083480768C105702510 @default.
• W2083480768 hasConceptScore W2083480768C12554922 @default.
• W2083480768 hasConceptScore W2083480768C126322002 @default.
• W2083480768 hasConceptScore W2083480768C164705383 @default.
• W2083480768 hasConceptScore W2083480768C185263204 @default.
• W2083480768 hasConceptScore W2083480768C2777463368 @default.
• W2083480768 hasConceptScore W2083480768C2778875491 @default.
• W2083480768 hasConceptScore W2083480768C2778921608 @default.
• W2083480768 hasConceptScore W2083480768C71924100 @default.
• W2083480768 hasConceptScore W2083480768C85378888 @default.
• W2083480768 hasConceptScore W2083480768C86803240 @default.
• W2083480768 hasIssue "8" @default.
• W2083480768 hasLocation W20834807681 @default.
• W2083480768 hasLocation W20834807682 @default.
• W2083480768 hasOpenAccess W2083480768 @default.
• W2083480768 hasPrimaryLocation W20834807681 @default.
• W2083480768 hasRelatedWork W2026247776 @default.
• W2083480768 hasRelatedWork W2032356666 @default.
• W2083480768 hasRelatedWork W2048008314 @default.
• W2083480768 hasRelatedWork W2078545226 @default.
• W2083480768 hasRelatedWork W2095597373 @default.
• W2083480768 hasRelatedWork W2135484958 @default.
• W2083480768 hasRelatedWork W2994046506 @default.
• W2083480768 hasRelatedWork W4230334346 @default.
• W2083480768 hasRelatedWork W4290435227 @default.
• W2083480768 hasRelatedWork W80816950 @default.
• W2083480768 hasVolume "6" @default.

• next