FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083497989> ?p ?o ?g. }

• W2083497989 endingPage "4511" @default.
• W2083497989 startingPage "4503" @default.
• W2083497989 abstract "This study examines whether the serine/threonine protein kinase, Akt, is involved in the cross-talk between epidermal growth factor (EGF) and insulin-related growth factor I (IGF-I) receptors and ER-alpha. Treatment of MCF-7 cells with either EGF or IGF-I resulted in a rapid phosphorylation of Akt and a 14- to 16-fold increase in Akt activity, respectively. Akt activation was blocked by inhibitors of phosphatidylinositol 3-kinase, but not by an inhibitor of the ribosomal protein kinase p70S6K. Stable transfection of cells with a dominant negative Akt mutant blocked the effects of EGF and IGF-I on ER-alpha expression and activity, whereas stable transfection of cells with a constitutively active Akt mutant mimicked the effects of EGF and IGF-I. In the latter cells, there was a decrease in the amount of ER-alpha protein and messenger RNA (70-80%) and an increase in the amount of progesterone receptor protein, messenger RNA (4- to 9- and by 3.5- to 7-fold, respectively) and pS2 (3- to 5-fold). Coexpression of wild-type ER-alpha and the dominant negative Akt mutant in COS-1 cells also blocked the growth factor-stimulated activation of ER-alpha, but coexpression of the wild-type receptor with the constitutively active Akt mutant increased ER-alpha activity. Receptor activation was blocked by an antiestrogen. Studies using mutants of ER-alpha demonstrated that Akt increased estrogen receptor activity through the amino-terminal activation function-1 (AF-1). Serines S104 S106, S118, and S167 appear to play a role in the activation of ER-alpha by Akt." @default.
• W2083497989 created "2016-06-24" @default.
• W2083497989 creator A5031280966 @default.
• W2083497989 creator A5034809007 @default.
• W2083497989 creator A5062855220 @default.
• W2083497989 creator A5079392139 @default.
• W2083497989 creator A5080531304 @default.
• W2083497989 creator A5083283335 @default.
• W2083497989 creator A5085761422 @default.
• W2083497989 creator A5088052652 @default.
• W2083497989 creator A5089626836 @default.
• W2083497989 date "2000-12-01" @default.
• W2083497989 modified "2023-10-16" @default.
• W2083497989 title "A Role for Akt in Mediating the Estrogenic Functions of Epidermal Growth Factor and Insulin-Like Growth Factor I¹" @default.
• W2083497989 cites W119017381 @default.
• W2083497989 cites W1479965447 @default.
• W2083497989 cites W1520299947 @default.
• W2083497989 cites W1571431043 @default.
• W2083497989 cites W1573821584 @default.
• W2083497989 cites W1726025741 @default.
• W2083497989 cites W1915833704 @default.
• W2083497989 cites W1954929088 @default.
• W2083497989 cites W1966089335 @default.
• W2083497989 cites W1979909416 @default.
• W2083497989 cites W1983901656 @default.
• W2083497989 cites W1989627660 @default.
• W2083497989 cites W1999186716 @default.
• W2083497989 cites W2000111014 @default.
• W2083497989 cites W2004078164 @default.
• W2083497989 cites W2008291690 @default.
• W2083497989 cites W2008987764 @default.
• W2083497989 cites W2010042688 @default.
• W2083497989 cites W2010401605 @default.
• W2083497989 cites W2013238591 @default.
• W2083497989 cites W2014745119 @default.
• W2083497989 cites W2014967694 @default.
• W2083497989 cites W2029475329 @default.
• W2083497989 cites W2032095724 @default.
• W2083497989 cites W2039193709 @default.
• W2083497989 cites W2044868069 @default.
• W2083497989 cites W2050498522 @default.
• W2083497989 cites W2059153388 @default.
• W2083497989 cites W2059221693 @default.
• W2083497989 cites W2061713372 @default.
• W2083497989 cites W2062860025 @default.
• W2083497989 cites W2072787342 @default.
• W2083497989 cites W2077478539 @default.
• W2083497989 cites W2080778537 @default.
• W2083497989 cites W2087027920 @default.
• W2083497989 cites W2087729478 @default.
• W2083497989 cites W2087904456 @default.
• W2083497989 cites W2090551359 @default.
• W2083497989 cites W2093604426 @default.
• W2083497989 cites W2097349743 @default.
• W2083497989 cites W2102414600 @default.
• W2083497989 cites W2113280225 @default.
• W2083497989 cites W2127890495 @default.
• W2083497989 cites W2130826810 @default.
• W2083497989 cites W2146697101 @default.
• W2083497989 cites W2146854995 @default.
• W2083497989 cites W2152186846 @default.
• W2083497989 cites W2316574060 @default.
• W2083497989 cites W2343796556 @default.
• W2083497989 cites W2907439807 @default.
• W2083497989 cites W46228081 @default.
• W2083497989 cites W8163034 @default.
• W2083497989 cites W89084389 @default.
• W2083497989 doi "https://doi.org/10.1210/endo.141.12.7836" @default.
• W2083497989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11108261" @default.
• W2083497989 hasPublicationYear "2000" @default.
• W2083497989 type Work @default.
• W2083497989 sameAs 2083497989 @default.
• W2083497989 citedByCount "192" @default.
• W2083497989 countsByYear W20834979892012 @default.
• W2083497989 countsByYear W20834979892013 @default.
• W2083497989 countsByYear W20834979892014 @default.
• W2083497989 countsByYear W20834979892015 @default.
• W2083497989 countsByYear W20834979892016 @default.
• W2083497989 countsByYear W20834979892017 @default.
• W2083497989 countsByYear W20834979892018 @default.
• W2083497989 countsByYear W20834979892019 @default.
• W2083497989 countsByYear W20834979892020 @default.
• W2083497989 countsByYear W20834979892021 @default.
• W2083497989 countsByYear W20834979892022 @default.
• W2083497989 countsByYear W20834979892023 @default.
• W2083497989 crossrefType "journal-article" @default.
• W2083497989 hasAuthorship W2083497989A5031280966 @default.
• W2083497989 hasAuthorship W2083497989A5034809007 @default.
• W2083497989 hasAuthorship W2083497989A5062855220 @default.
• W2083497989 hasAuthorship W2083497989A5079392139 @default.
• W2083497989 hasAuthorship W2083497989A5080531304 @default.
• W2083497989 hasAuthorship W2083497989A5083283335 @default.
• W2083497989 hasAuthorship W2083497989A5085761422 @default.
• W2083497989 hasAuthorship W2083497989A5088052652 @default.
• W2083497989 hasAuthorship W2083497989A5089626836 @default.
• W2083497989 hasBestOaLocation W20834979891 @default.
• W2083497989 hasConcept C104202773 @default.
• W2083497989 hasConcept C11960822 @default.

• next