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• W2083505522 abstract "Nasopharyngeal carcinoma (NPC) is an Epstein–Barr Virus (EBV)-associated cancer that is the fifth most common cancer in Malaysia. Early and accurate diagnoses are critical for patient prognosis. Unfortunately, early detection of NPC is still a challenge and the cost of more accurate imaging protocols is prohibitive in developing countries like Malaysia. To evaluate the clinical values of pre-treatment plasma EBV DNA levels in Malaysian NPC patients. Plasma EBV DNA levels were measured by quantitative PCR (Q-PCR) in a large and multi-ethnic cohort of Malaysian patients with NPC (n = 459) and 72 control subjects. We show for the first time that, compared to controls, NPC patients with stage I disease had significantly higher levels of EBV DNA (p < 0.001). Further, the median level of plasma EBV DNA in stage IV patients with distant metastasis was >9-fold higher than those without systemic spread (p = 0.001), suggesting plasma EBV DNA measurement could aid in the diagnosis of metastatic disease in advanced cases. Further, using a cut-off value of 8000 copies/mL, we demonstrate that EBV DNA level is a strong predictor for overall survival of NPC patients. Our data show that pre-treatment plasma EBV DNA is a potential biomarker for early stage and metastatic NPC. We conclude that the quantification of plasma EBV DNA is a useful tool in developing countries to stratify patients for MRI or PET/CT scans where such imaging protocol is not routinely applied." @default.
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• W2083505522 date "2012-09-01" @default.
• W2083505522 modified "2023-09-27" @default.
• W2083505522 title "Clinical significance of plasma Epstein–Barr Virus DNA loads in a large cohort of Malaysian patients with nasopharyngeal carcinoma" @default.
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• W2083505522 doi "https://doi.org/10.1016/j.jcv.2012.05.017" @default.
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