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• W2083515804 abstract "Statins are the most widely prescribed and effective medication for reducing low density lipoprotein cholesterol. Statins may also lower resting blood pressure (BP); however, results are inconsistent. We sought to determine if the maximum dose of atorvastatin reduces resting BP and the peak systolic BP (SBP) achieved on a graded exercise stress test (GEST) among a large sample of 419 healthy men (48%) and women (52%). Subjects (419, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mn>44.1</mml:mn><mml:mo>±</mml:mo><mml:mn>0.8</mml:mn></mml:math> yr) were double-blinded and randomized to 80 mg<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mo>·</mml:mo></mml:mrow></mml:math>d −1 of atorvastatin (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>202</mml:mn></mml:math>) or placebo (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>217</mml:mn></mml:math>) for 6 mo. Among the total sample, there were no differences in resting BP (SBP, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.30</mml:mn></mml:math>; diastolic BP [DBP], <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.69</mml:mn></mml:math>; mean arterial pressure (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.76</mml:mn></mml:math>); or peak SBP on a GEST (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.99</mml:mn></mml:math>)) over 6 mo, regardless of drug treatment group. However, among women on atorvastatin, resting SBP/DBP (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mn>3.7</mml:mn><mml:mo>±</mml:mo><mml:mn>1.5</mml:mn></mml:math> mmHg, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.01</mml:mn><mml:mo>/</mml:mo><mml:mn>3.2</mml:mn><mml:mo>±</mml:mo><mml:mn>0.9</mml:mn></mml:math> mmHg, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.02</mml:mn></mml:math>) and peak SBP on a GEST (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mn>6.5</mml:mn><mml:mo>±</mml:mo><mml:mn>1.5</mml:mn></mml:math> mmHg, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M13><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.04</mml:mn></mml:math>) were lower versus men. Atorvastatin lowered resting BP 3-4 mmHg and peak SBP on a GEST ~7 mmHg more among women than men over 6 mo of treatment. The inconsistent findings regarding the antihypertensive effects of statins may be partially explained by not accounting for sex effects." @default.
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• W2083515804 date "2014-11-18" @default.
• W2083515804 modified "2023-10-16" @default.
• W2083515804 title "Effects of Atorvastatin on Resting and Peak Exercise Blood Pressure among Normotensive Men and Women" @default.
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• W2083515804 doi "https://doi.org/10.1155/2014/720507" @default.
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