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- W2083518460 endingPage "11311" @default.
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- W2083518460 abstract "l-Arginine (Arg) is oxidized to l-citrulline and nitric oxide (NO) by the action of endothelial nitric oxide synthase (NOS). In contrast, protein-incorporated Arg residues can be methylated with subsequent proteolysis giving rise to methylarginine compounds, such as asymmetric dimethylarginine (ADMA) that competes with Arg for binding to NOS. Most ADMA is degraded by dimethylarginine dimethyaminohydrolase (DDAH), distributed widely throughout the body and regulates ADMA levels and, therefore, NO synthesis. In recent years, several studies have suggested that increased ADMA levels are a marker of atherosclerotic change, and can be used to assess cardiovascular risk, consistent with ADMA being predominantly absorbed by endothelial cells. NO is an important messenger molecule involved in numerous biological processes, and its activity is essential to understand both pathogenic and therapeutic mechanisms in kidney disease and renal transplantation. NO production is reduced in renal patients because of their elevated ADMA levels with associated reduced DDAH activity. These factors contribute to endothelial dysfunction, oxidative stress and the progression of renal damage, but there are treatments that may effectively reduce ADMA levels in patients with kidney disease. Available data on ADMA levels in controls and renal patients, both in adults and children, also are summarized in this review." @default.
- W2083518460 created "2016-06-24" @default.
- W2083518460 creator A5063174554 @default.
- W2083518460 creator A5065348183 @default.
- W2083518460 date "2012-09-10" @default.
- W2083518460 modified "2023-09-26" @default.
- W2083518460 title "Asymmetric Dimethylarginine, Endothelial Dysfunction and Renal Disease" @default.
- W2083518460 cites W1789311305 @default.
- W2083518460 cites W1899699286 @default.
- W2083518460 cites W1965585323 @default.
- W2083518460 cites W1966929474 @default.
- W2083518460 cites W1967569297 @default.
- W2083518460 cites W1969796049 @default.
- W2083518460 cites W1970798352 @default.
- W2083518460 cites W1973145289 @default.
- W2083518460 cites W1979761529 @default.
- W2083518460 cites W1981268963 @default.
- W2083518460 cites W1985747103 @default.
- W2083518460 cites W1985946354 @default.
- W2083518460 cites W1987186964 @default.
- W2083518460 cites W1990549327 @default.
- W2083518460 cites W1990863512 @default.
- W2083518460 cites W1999278602 @default.
- W2083518460 cites W1999750490 @default.
- W2083518460 cites W2003045138 @default.
- W2083518460 cites W2003340777 @default.
- W2083518460 cites W2004837312 @default.
- W2083518460 cites W2007793016 @default.
- W2083518460 cites W2009561278 @default.
- W2083518460 cites W2012144927 @default.
- W2083518460 cites W2013653338 @default.
- W2083518460 cites W2014427275 @default.
- W2083518460 cites W2016979814 @default.
- W2083518460 cites W2019406766 @default.
- W2083518460 cites W2021387524 @default.
- W2083518460 cites W2024746608 @default.
- W2083518460 cites W2025891985 @default.
- W2083518460 cites W2033089638 @default.
- W2083518460 cites W2033609530 @default.
- W2083518460 cites W2033631367 @default.
- W2083518460 cites W2037709367 @default.
- W2083518460 cites W2039819831 @default.
- W2083518460 cites W2042800607 @default.
- W2083518460 cites W2044642923 @default.
- W2083518460 cites W2048121996 @default.
- W2083518460 cites W2050157038 @default.
- W2083518460 cites W2051090826 @default.
- W2083518460 cites W2051582832 @default.
- W2083518460 cites W2052631825 @default.
- W2083518460 cites W2053481736 @default.
- W2083518460 cites W2056644854 @default.
- W2083518460 cites W2058343608 @default.
- W2083518460 cites W2058570967 @default.
- W2083518460 cites W2059095384 @default.
- W2083518460 cites W2061976121 @default.
- W2083518460 cites W2064796583 @default.
- W2083518460 cites W2073950591 @default.
- W2083518460 cites W2075172325 @default.
- W2083518460 cites W2075608865 @default.
- W2083518460 cites W2076355884 @default.
- W2083518460 cites W2076680300 @default.
- W2083518460 cites W2080127004 @default.
- W2083518460 cites W2080171932 @default.
- W2083518460 cites W2082661372 @default.
- W2083518460 cites W2084828016 @default.
- W2083518460 cites W2085909218 @default.
- W2083518460 cites W2086144155 @default.
- W2083518460 cites W2088632030 @default.
- W2083518460 cites W2089313777 @default.
- W2083518460 cites W2090170448 @default.
- W2083518460 cites W2090443996 @default.
- W2083518460 cites W2090706356 @default.
- W2083518460 cites W2090890003 @default.
- W2083518460 cites W2091283262 @default.
- W2083518460 cites W2097066618 @default.
- W2083518460 cites W2098487456 @default.
- W2083518460 cites W2099907445 @default.
- W2083518460 cites W2104581763 @default.
- W2083518460 cites W2106169918 @default.
- W2083518460 cites W2106422918 @default.
- W2083518460 cites W2106535141 @default.
- W2083518460 cites W2107818859 @default.
- W2083518460 cites W2108606693 @default.
- W2083518460 cites W2113339507 @default.
- W2083518460 cites W2117349051 @default.
- W2083518460 cites W2119861336 @default.
- W2083518460 cites W2122065321 @default.
- W2083518460 cites W2123178954 @default.
- W2083518460 cites W2123993612 @default.
- W2083518460 cites W2124279221 @default.
- W2083518460 cites W2133104120 @default.
- W2083518460 cites W2133135624 @default.
- W2083518460 cites W2133576127 @default.
- W2083518460 cites W2133774741 @default.
- W2083518460 cites W2135369804 @default.
- W2083518460 cites W2135617339 @default.
- W2083518460 cites W2142172510 @default.
- W2083518460 cites W2145802142 @default.