Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083527679> ?p ?o ?g. }
- W2083527679 endingPage "133" @default.
- W2083527679 startingPage "123" @default.
- W2083527679 abstract "Seventeen relapsing–remitting (R/R) multiple sclerosis (MS) patients and age/sex matched controls were studied every 6 weeks for 2 years. Disease activity, determined both clinically and by serial MRI, was correlated with natural killer (NK) cell functional activity (FA) and phenotype. Mean NK cell FA is significantly lower in MS patients, compared to controls (P<0.001), while variability around the means is significantly greater (P<0.01). The spectrum of mean NK cell FA, observed in the patient cohort, along with cyclical nature of the FA and phenotype over time, observed in both patients and controls, may begin to explain the discrepant results reported in previous studies. In R/R MS, there is a significant correlation between reductions (valleys) in NK cell FA and the development of active lesions on MRI, new (P<0.001) or enlarging (P=0.05). More importantly, a significant number of active lesions, new (P=0.01) and enlarging (P=0.02), are preceded by a reduction in NK cell FA. The correlation between the onset of clinical attacks and valleys of NK cell FA is also significant (P=0.002). When taken together, the results suggest that reductions (valleys) in NK cell FA represent periods of susceptibility for the development of active lesions on MRI and clinical attacks. A significant positive correlation is also identified between mean NK cell FA for each R/R MS patient and total number of active MRI lesions developed by that patient over the 2 years (P=0.001). The results would suggest that R/R MS patients with a higher mean NK cell FA are at greater risk for the development of active lesions. These results support the proposal that NK cells may play a role in the immunopathogenesis of R/R MS." @default.
- W2083527679 created "2016-06-24" @default.
- W2083527679 creator A5003703784 @default.
- W2083527679 creator A5014349713 @default.
- W2083527679 creator A5024460308 @default.
- W2083527679 creator A5030545268 @default.
- W2083527679 creator A5062630442 @default.
- W2083527679 creator A5065850453 @default.
- W2083527679 creator A5075612393 @default.
- W2083527679 date "1998-06-01" @default.
- W2083527679 modified "2023-09-26" @default.
- W2083527679 title "A role for natural killer cells in the immunopathogenesis of multiple sclerosis" @default.
- W2083527679 cites W1489850871 @default.
- W2083527679 cites W1504038693 @default.
- W2083527679 cites W1510592856 @default.
- W2083527679 cites W1542501019 @default.
- W2083527679 cites W1556867369 @default.
- W2083527679 cites W159682276 @default.
- W2083527679 cites W1604871681 @default.
- W2083527679 cites W1649008823 @default.
- W2083527679 cites W1760041358 @default.
- W2083527679 cites W1783984636 @default.
- W2083527679 cites W1923737223 @default.
- W2083527679 cites W1966212138 @default.
- W2083527679 cites W1994979699 @default.
- W2083527679 cites W1995410544 @default.
- W2083527679 cites W1998398900 @default.
- W2083527679 cites W2001071033 @default.
- W2083527679 cites W2004889721 @default.
- W2083527679 cites W2017372938 @default.
- W2083527679 cites W2023804521 @default.
- W2083527679 cites W2025188867 @default.
- W2083527679 cites W2045144251 @default.
- W2083527679 cites W2045964137 @default.
- W2083527679 cites W2048159994 @default.
- W2083527679 cites W2053572501 @default.
- W2083527679 cites W2055801484 @default.
- W2083527679 cites W2056124282 @default.
- W2083527679 cites W2057549315 @default.
- W2083527679 cites W2058784036 @default.
- W2083527679 cites W2059167513 @default.
- W2083527679 cites W2061983128 @default.
- W2083527679 cites W2066433792 @default.
- W2083527679 cites W2075933266 @default.
- W2083527679 cites W2083536542 @default.
- W2083527679 cites W2085516673 @default.
- W2083527679 cites W2088617902 @default.
- W2083527679 cites W2104417744 @default.
- W2083527679 cites W2122956735 @default.
- W2083527679 cites W2127022844 @default.
- W2083527679 cites W2142521847 @default.
- W2083527679 cites W2161074465 @default.
- W2083527679 cites W2161082695 @default.
- W2083527679 cites W2165547142 @default.
- W2083527679 cites W2246548868 @default.
- W2083527679 cites W2315046448 @default.
- W2083527679 cites W382746649 @default.
- W2083527679 cites W4313313462 @default.
- W2083527679 doi "https://doi.org/10.1016/s0165-5728(98)00014-9" @default.
- W2083527679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9663557" @default.
- W2083527679 hasPublicationYear "1998" @default.
- W2083527679 type Work @default.
- W2083527679 sameAs 2083527679 @default.
- W2083527679 citedByCount "89" @default.
- W2083527679 countsByYear W20835276792012 @default.
- W2083527679 countsByYear W20835276792013 @default.
- W2083527679 countsByYear W20835276792014 @default.
- W2083527679 countsByYear W20835276792015 @default.
- W2083527679 countsByYear W20835276792016 @default.
- W2083527679 countsByYear W20835276792017 @default.
- W2083527679 countsByYear W20835276792018 @default.
- W2083527679 countsByYear W20835276792019 @default.
- W2083527679 countsByYear W20835276792021 @default.
- W2083527679 countsByYear W20835276792023 @default.
- W2083527679 crossrefType "journal-article" @default.
- W2083527679 hasAuthorship W2083527679A5003703784 @default.
- W2083527679 hasAuthorship W2083527679A5014349713 @default.
- W2083527679 hasAuthorship W2083527679A5024460308 @default.
- W2083527679 hasAuthorship W2083527679A5030545268 @default.
- W2083527679 hasAuthorship W2083527679A5062630442 @default.
- W2083527679 hasAuthorship W2083527679A5065850453 @default.
- W2083527679 hasAuthorship W2083527679A5075612393 @default.
- W2083527679 hasConcept C104317684 @default.
- W2083527679 hasConcept C117220453 @default.
- W2083527679 hasConcept C126322002 @default.
- W2083527679 hasConcept C127716648 @default.
- W2083527679 hasConcept C142724271 @default.
- W2083527679 hasConcept C1491633281 @default.
- W2083527679 hasConcept C154317977 @default.
- W2083527679 hasConcept C202751555 @default.
- W2083527679 hasConcept C203014093 @default.
- W2083527679 hasConcept C2524010 @default.
- W2083527679 hasConcept C2778102761 @default.
- W2083527679 hasConcept C2780640218 @default.
- W2083527679 hasConcept C33923547 @default.
- W2083527679 hasConcept C54355233 @default.
- W2083527679 hasConcept C71924100 @default.
- W2083527679 hasConcept C72563966 @default.