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• W2083539097 abstract "Osteoclasts dissolve mineralized bone matrix at bone resorption sites and release large amounts of calcium (Ca2+) and phosphate (PO43−) ions into the extracellular fluid. However, the exact nature of Ca2+ and PO43− on osteoblasts remains unclear. We proposed that Ca2+ and PO43− ions are required for the expression of sodium-dependent vitamin C transporter (SVCT) 2 and a differentiation marker, osteopontin (OPN), in osteoblasts as a response to the osteoclastic degradation. Results from Northern blotting indicated that a deficiency of Ca2+ or PO43− inhibited both SVCT2 and OPN expression in a time-dependent manner, whereas elevated Ca2+ (1 to 4 mM) or PO43− (1 to 4 mM) dose-dependently induced SVCT2, OPN expression and OPN promoter activity. In addition, the L-type calcium channel blocker, nifedipine (5 to 20 μM) and the phosphate transporter inhibitor, foscarnet (0.15 to 0.6 mM), dose-dependently abolished Ca2+- and PO43−-induced SVCT2, OPN expression and OPN promoter activity. Furthermore, the results from l-ascorbic acid uptake assay and Western blotting indicated that the stimulatory effect of Ca2+ and PO43− on functional SVCT2 protein expression. These findings suggested that Ca2+ and PO43− regulate osteoblastic phenotype by entering into cells to stimulate SVCT2 and OPN expression." @default.
• W2083539097 created "2016-06-24" @default.
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• W2083539097 date "2003-06-01" @default.
• W2083539097 modified "2023-10-10" @default.
• W2083539097 title "Requirement of calcium and phosphate ions in expression of sodium-dependent vitamin C transporter 2 and osteopontin in MC3T3-E1 osteoblastic cells" @default.
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• W2083539097 doi "https://doi.org/10.1016/s0167-4889(03)00065-x" @default.
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