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- W2083556161 abstract "Abstract The formation of hemoglobin - carcinogen adducts has been detected in carcinogen treated animals and in human populations. Although polycyclic aromatic hydrocarbons are ubiquitous in the human environment and DNA - aromatic hydrocarbon adducts have been detected in human tissue, the occurrence of hemoglobin - polycyclic aromatic hydrocarbon adducts in humans has not been thoroughly described. In this study we examined the effects of reaction condition on the extent of in vitro reaction of human hemoglobin and (+) [3H]benzo[a]pyrene-7,8-diol-9,10-epoxide (anti)(BPDE), a metabolite thought to be largely responsible for the carcinogenic effect of benzo[a]pyrene. The chromatographic properties of the resulting hemoglobin - BPDE adducts were examined by conventional DEAE-cellulose ion exchange liquid chromatography and by reversed phase high performance liquid chromatography. Several adducts were formed which were chromatographically resolved from hemoglobin and from the individual globins. Some adducts were basic and some acidic relative to unaltered hemoglobin, suggesting adduct formation by reaction at carboxyl and basic nitrogen groups, respectively. Alteration of the ion - chromatographic properties of the adducts by an ionic sulfhydryl reagent indicated that the adducts were not formed via reaction with the β93 cysteine sulfhydryl groups. The chromatographic techniques employed may be applicable for the characterization and analysis of other hemoglobin - carcinogen adducts. Key Words: HemoglobinBenzo[a]pyreneChromatographyAdductsCarcinogenBiomarkers" @default.
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- W2083556161 date "1994-08-01" @default.
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- W2083556161 title "Reaction of Benzo[a]pyrene-7,8-diol-9,10-epoxide with Human Hemoglobin and the Chromatographic Resolution of the Covalent Adducts" @default.
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- W2083556161 doi "https://doi.org/10.1080/10406639408031178" @default.
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