FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083564303> ?p ?o ?g. }

• W2083564303 endingPage "776" @default.
• W2083564303 startingPage "770" @default.
• W2083564303 abstract "In Brief The leading cause of transfusion-related morbidity and mortality in the United States is transfusion-related acute lung injury (TRALI). Diagnostic criteria for TRALI have recently been developed and primarily consist of hypoxia and bilateral pulmonary edema occurring during or within 6 h of a transfusion in the absence of cardiac failure or intravascular volume overload. The primary differential diagnosis is transfusion-associated circulatory overload and differentiation can be difficult. Treatment is supportive with oxygen and mechanical ventilation. Diuresis is not indicated and the role of steroids is unproven. Patients typically recover within a few days. All types of blood products have been associated with TRALI, however, the plasma-rich components, such as fresh frozen plasma and apheresis platelets, have been most frequently implicated. The pathogenesis of TRALI is not completely understood. Leukocyte antibodies in donor plasma have been implicated in most cases with antibodies directed at human leukocyte antigen (HLA) class I, HLA class II or neutrophil-specific antigens, particularly HNA-3a. Activation of pulmonary endothelium is important in the development of TRALI and may account for most cases being observed in surgical or intensive care unit patients. Transfused leukoagglutinating antibodies bind to recipients’ neutrophils localized to pulmonary endothelium resulting in activation and release of oxidases and other damaging biologic response modifiers that cause capillary leak. In a minority of TRALI cases, no antibodies are identified and it is postulated that neutrophil priming factors in the transfused component can mediate TRALI in a patient with pulmonary endothelial activation, the so called “two hit” mechanism. Recognition of the role of anti-leukocyte antibodies has led to new strategies to reduce the risk of TRALI. Female blood donors with a previous pregnancy frequently have HLA antibodies with an overall prevalence of 24% and increasing prevalence related to the number of previous pregnancies. Since HLA antibodies have been implicated in TRALI, blood centers have adopted policies to produce plasma components primarily from male donors. Strategies to reduce the risk from apheresis platelets are problematic and are likely to involve testing female apheresis platelet donors for HLA antibodies. Much more research is needed to understand the blood component and patient risk factors for TRALI so that novel strategies for treatment and additional measures to reduce the risk of TRALI can be developed. IMPLICATIONS: TRALI is an acute lung injury syndrome associated with transfusion and nows represents the most common cause of death from transfusion. Physician who transfuse patient must be familiar with the recognition and management of this complication." @default.
• W2083564303 created "2016-06-24" @default.
• W2083564303 creator A5008827736 @default.
• W2083564303 date "2009-03-01" @default.
• W2083564303 modified "2023-10-12" @default.
• W2083564303 title "Transfusion-Related Acute Lung Injury: Current Concepts for the Clinician" @default.
• W2083564303 cites W1918355653 @default.
• W2083564303 cites W1964095702 @default.
• W2083564303 cites W1967640548 @default.
• W2083564303 cites W1968573702 @default.
• W2083564303 cites W1974410179 @default.
• W2083564303 cites W1982031226 @default.
• W2083564303 cites W1983318857 @default.
• W2083564303 cites W1985352910 @default.
• W2083564303 cites W1986063899 @default.
• W2083564303 cites W1992458520 @default.
• W2083564303 cites W1993546125 @default.
• W2083564303 cites W1994308427 @default.
• W2083564303 cites W1996573036 @default.
• W2083564303 cites W1996760444 @default.
• W2083564303 cites W1996958745 @default.
• W2083564303 cites W2004668542 @default.
• W2083564303 cites W2007900655 @default.
• W2083564303 cites W2022840790 @default.
• W2083564303 cites W2026425106 @default.
• W2083564303 cites W2029213593 @default.
• W2083564303 cites W2032905340 @default.
• W2083564303 cites W2041600306 @default.
• W2083564303 cites W2045244853 @default.
• W2083564303 cites W2045287873 @default.
• W2083564303 cites W2048829599 @default.
• W2083564303 cites W2054375284 @default.
• W2083564303 cites W2057493194 @default.
• W2083564303 cites W2061459967 @default.
• W2083564303 cites W2065130385 @default.
• W2083564303 cites W2071688599 @default.
• W2083564303 cites W2076988730 @default.
• W2083564303 cites W2094771549 @default.
• W2083564303 cites W2098355694 @default.
• W2083564303 cites W2099073736 @default.
• W2083564303 cites W2100198018 @default.
• W2083564303 cites W2104440541 @default.
• W2083564303 cites W2111403445 @default.
• W2083564303 cites W2121530386 @default.
• W2083564303 cites W2129724071 @default.
• W2083564303 cites W2143050617 @default.
• W2083564303 cites W2146844204 @default.
• W2083564303 cites W2147269621 @default.
• W2083564303 cites W2153503857 @default.
• W2083564303 cites W2160878167 @default.
• W2083564303 cites W2164126145 @default.
• W2083564303 cites W3113100813 @default.
• W2083564303 cites W4321509092 @default.
• W2083564303 doi "https://doi.org/10.1213/ane.0b013e31819029b2" @default.
• W2083564303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19224781" @default.
• W2083564303 hasPublicationYear "2009" @default.
• W2083564303 type Work @default.
• W2083564303 sameAs 2083564303 @default.
• W2083564303 citedByCount "149" @default.
• W2083564303 countsByYear W20835643032012 @default.
• W2083564303 countsByYear W20835643032013 @default.
• W2083564303 countsByYear W20835643032014 @default.
• W2083564303 countsByYear W20835643032015 @default.
• W2083564303 countsByYear W20835643032016 @default.
• W2083564303 countsByYear W20835643032017 @default.
• W2083564303 countsByYear W20835643032018 @default.
• W2083564303 countsByYear W20835643032019 @default.
• W2083564303 countsByYear W20835643032020 @default.
• W2083564303 countsByYear W20835643032021 @default.
• W2083564303 countsByYear W20835643032022 @default.
• W2083564303 crossrefType "journal-article" @default.
• W2083564303 hasAuthorship W2083564303A5008827736 @default.
• W2083564303 hasBestOaLocation W20835643031 @default.
• W2083564303 hasConcept C126322002 @default.
• W2083564303 hasConcept C147483822 @default.
• W2083564303 hasConcept C177713679 @default.
• W2083564303 hasConcept C188280979 @default.
• W2083564303 hasConcept C203014093 @default.
• W2083564303 hasConcept C2776468924 @default.
• W2083564303 hasConcept C2776689292 @default.
• W2083564303 hasConcept C2777259802 @default.
• W2083564303 hasConcept C2777714996 @default.
• W2083564303 hasConcept C2780014101 @default.
• W2083564303 hasConcept C2780942790 @default.
• W2083564303 hasConcept C2781003276 @default.
• W2083564303 hasConcept C66112548 @default.
• W2083564303 hasConcept C71924100 @default.
• W2083564303 hasConcept C89560881 @default.
• W2083564303 hasConceptScore W2083564303C126322002 @default.
• W2083564303 hasConceptScore W2083564303C147483822 @default.
• W2083564303 hasConceptScore W2083564303C177713679 @default.
• W2083564303 hasConceptScore W2083564303C188280979 @default.
• W2083564303 hasConceptScore W2083564303C203014093 @default.
• W2083564303 hasConceptScore W2083564303C2776468924 @default.
• W2083564303 hasConceptScore W2083564303C2776689292 @default.
• W2083564303 hasConceptScore W2083564303C2777259802 @default.
• W2083564303 hasConceptScore W2083564303C2777714996 @default.
• W2083564303 hasConceptScore W2083564303C2780014101 @default.

• next