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• W2083572023 abstract "Leech embryos develop via stereotyped cell divisions, many of which are unequal. The first division generates identifiable cells, blastomeres AB and CD, which normally follow distinct developmental pathways. When these two cells are dissociated and cultured in isolation, their fates remain distinct and are reminiscent of normal development, but their typical cleavage patterns are disrupted; cell AB undergoes relatively few cell divisions, giving rise to a variable number of macromeres and micromeres, while cell CD cleaves many times, usually forming a poorly organized set of macromeres, embryonic stem cells (teloblasts), and micromeres. We have investigated the hypothesis that the abnormal cleavage pattern of isolated CD blastomeres is due to removal of mechanical constraints normally imposed by cell AB. We find that when cell CD is constrained in vitro to mimic its in vivo shape, it cleaves more normally." @default.
• W2083572023 created "2016-06-24" @default.
• W2083572023 creator A5083850738 @default.
• W2083572023 creator A5089700192 @default.
• W2083572023 date "1992-03-01" @default.
• W2083572023 modified "2023-10-15" @default.
• W2083572023 title "An investigation of the specification of unequal cleavages in leech embryos" @default.
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• W2083572023 doi "https://doi.org/10.1016/0012-1606(92)90019-d" @default.
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• W2083572023 hasPublicationYear "1992" @default.
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