FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083576502> ?p ?o ?g. }

• W2083576502 endingPage "200" @default.
• W2083576502 startingPage "194" @default.
• W2083576502 abstract "Background and aims Adverse events (AE) leading to discontinuation or dose-reduction of thiopurine therapy (TP) occur in 9–28% of patients with inflammatory bowel disease. 6-Thioguanine (6-TG) has been proposed as an alternative treatment in patients intolerant for azathioprine (AZA), but some concerns have been raised about drug safety. Methods We evaluated in a prospective manner the tolerance and efficacy of 6-TG in 23 Crohn's disease (CD) patients (13 men, median age 41 (19–65) years) with prior intolerance (n = 18) or resistance (n = 5) to AZA and/or 6-mercaptopurine (6-MP). In addition, eight patients had tried mycophenolate mofetil. Seventeen patients (74%) had undergone intestinal resection, often several times. Results Patients were treated with a median daily dose of 40 mg 6-TG (range 20–60) for 259 (15–2272) days. Seven of 13 patients (54%) with active disease went into remission after 8 (4–26) weeks. Sixteen patients (70%) experienced AE that lead to discontinuation (n = 10) after 85 (15–451) days or dose reduction (n = 6) after 78 (10–853) days. Ten of 18 patients (56%) with prior TP-intolerance discontinued 6-TG treatment due to AE compared to none of five patients with TP-resistance (p = 0.046). Of 13 patients that tolerated 6-TG, eight discontinued the drug due to therapeutic failure (n = 5) or safety concerns (n = 3). Eight patients (35%) continued treatment beyond 12 months. There was no significant difference in maximum thioguanine nucleotide levels between patients with AE leading to discontinuation/dose reduction and patients without AE, 652 (99–2488) vs. 551 (392–1574) pmol/8 × 108 RBC; p = 0.80. Conclusions In this cohort of CD patients with severe disease failing traditional thiopurine treatment, a small fraction (22%) had long-term benefit of 6-TG-treatment. 6-TG therapy seems to offer a limited therapeutic gain for patients intolerant to both AZA and 6-MP and other treatment options should be considered." @default.
• W2083576502 created "2016-06-24" @default.
• W2083576502 creator A5011694844 @default.
• W2083576502 creator A5019938824 @default.
• W2083576502 creator A5070381365 @default.
• W2083576502 date "2009-03-01" @default.
• W2083576502 modified "2023-09-24" @default.
• W2083576502 title "6-Thioguanine therapy in Crohn′s disease—Observational data in Swedish patients" @default.
• W2083576502 cites W1604764192 @default.
• W2083576502 cites W1963889098 @default.
• W2083576502 cites W1975192137 @default.
• W2083576502 cites W1981097265 @default.
• W2083576502 cites W1984844839 @default.
• W2083576502 cites W1992656588 @default.
• W2083576502 cites W2005395189 @default.
• W2083576502 cites W2016837646 @default.
• W2083576502 cites W2022661087 @default.
• W2083576502 cites W2022787044 @default.
• W2083576502 cites W2027611001 @default.
• W2083576502 cites W2027947307 @default.
• W2083576502 cites W2030471467 @default.
• W2083576502 cites W2031141890 @default.
• W2083576502 cites W2046194577 @default.
• W2083576502 cites W2052575498 @default.
• W2083576502 cites W2054837922 @default.
• W2083576502 cites W2058868649 @default.
• W2083576502 cites W2061446694 @default.
• W2083576502 cites W2073496329 @default.
• W2083576502 cites W2074567775 @default.
• W2083576502 cites W2091346856 @default.
• W2083576502 cites W2095882378 @default.
• W2083576502 cites W2139547491 @default.
• W2083576502 cites W2143534053 @default.
• W2083576502 cites W2160237124 @default.
• W2083576502 cites W315967697 @default.
• W2083576502 cites W4236928477 @default.
• W2083576502 cites W78543264 @default.
• W2083576502 doi "https://doi.org/10.1016/j.dld.2008.07.314" @default.
• W2083576502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18799369" @default.
• W2083576502 hasPublicationYear "2009" @default.
• W2083576502 type Work @default.
• W2083576502 sameAs 2083576502 @default.
• W2083576502 citedByCount "27" @default.
• W2083576502 countsByYear W20835765022012 @default.
• W2083576502 countsByYear W20835765022013 @default.
• W2083576502 countsByYear W20835765022015 @default.
• W2083576502 countsByYear W20835765022016 @default.
• W2083576502 countsByYear W20835765022017 @default.
• W2083576502 countsByYear W20835765022018 @default.
• W2083576502 countsByYear W20835765022019 @default.
• W2083576502 countsByYear W20835765022020 @default.
• W2083576502 countsByYear W20835765022022 @default.
• W2083576502 countsByYear W20835765022023 @default.
• W2083576502 crossrefType "journal-article" @default.
• W2083576502 hasAuthorship W2083576502A5011694844 @default.
• W2083576502 hasAuthorship W2083576502A5019938824 @default.
• W2083576502 hasAuthorship W2083576502A5070381365 @default.
• W2083576502 hasConcept C126322002 @default.
• W2083576502 hasConcept C141071460 @default.
• W2083576502 hasConcept C197934379 @default.
• W2083576502 hasConcept C2776760755 @default.
• W2083576502 hasConcept C2777173762 @default.
• W2083576502 hasConcept C2778260677 @default.
• W2083576502 hasConcept C2778715236 @default.
• W2083576502 hasConcept C2779134260 @default.
• W2083576502 hasConcept C2779280984 @default.
• W2083576502 hasConcept C70917649 @default.
• W2083576502 hasConcept C71924100 @default.
• W2083576502 hasConcept C90924648 @default.
• W2083576502 hasConceptScore W2083576502C126322002 @default.
• W2083576502 hasConceptScore W2083576502C141071460 @default.
• W2083576502 hasConceptScore W2083576502C197934379 @default.
• W2083576502 hasConceptScore W2083576502C2776760755 @default.
• W2083576502 hasConceptScore W2083576502C2777173762 @default.
• W2083576502 hasConceptScore W2083576502C2778260677 @default.
• W2083576502 hasConceptScore W2083576502C2778715236 @default.
• W2083576502 hasConceptScore W2083576502C2779134260 @default.
• W2083576502 hasConceptScore W2083576502C2779280984 @default.
• W2083576502 hasConceptScore W2083576502C70917649 @default.
• W2083576502 hasConceptScore W2083576502C71924100 @default.
• W2083576502 hasConceptScore W2083576502C90924648 @default.
• W2083576502 hasIssue "3" @default.
• W2083576502 hasLocation W20835765021 @default.
• W2083576502 hasLocation W20835765022 @default.
• W2083576502 hasOpenAccess W2083576502 @default.
• W2083576502 hasPrimaryLocation W20835765021 @default.
• W2083576502 hasRelatedWork W1976932609 @default.
• W2083576502 hasRelatedWork W2011866056 @default.
• W2083576502 hasRelatedWork W2045364602 @default.
• W2083576502 hasRelatedWork W2106159140 @default.
• W2083576502 hasRelatedWork W2126093067 @default.
• W2083576502 hasRelatedWork W2316734434 @default.
• W2083576502 hasRelatedWork W2334467272 @default.
• W2083576502 hasRelatedWork W2349662145 @default.
• W2083576502 hasRelatedWork W2781372331 @default.
• W2083576502 hasRelatedWork W3023349297 @default.
• W2083576502 hasVolume "41" @default.
• W2083576502 isParatext "false" @default.

• next