Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083583313> ?p ?o ?g. }
- W2083583313 endingPage "e67504" @default.
- W2083583313 startingPage "e67504" @default.
- W2083583313 abstract "Hesperetin (3',5,7-trihydroxy-4-methoxyflavanone) is a metabolite of hesperidin (hesperetin-7-O-rutinoside), which belongs to the flavanone subgroup and is found mainly in citrus fruits. Hesperetin has been reported to be an effective osteoinductive compound in various in vivo and in vitro models. However, how hesperetin effects osteogenic differentiation is not fully understood. In this study, we investigated the capacity of hesperetin to stimulate the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) and to relieve the anti-osteogenic effect of high glucose. Osteogenesis of PDLSCs was assessed by measurement of alkaline phosphatase (ALP) activity, and evaluation of the mRNA expression of ALP, runt-related gene 2 (Runx2), osterix (OSX), and FRA1 as osteogenic transcription factors, as well as assessment of protein expression of osteopontin (OPN) and collagen type IA (COLIA). When PDLSCs were exposed to a high concentration (30 mM) of glucose, osteogenic activity decreased compared to control cells. Hesperetin significantly increased ALP activity at doses of 1, 10, and 100 µM. Pretreatment of cells with hesperetin alleviated the high-glucose-induced suppression of the osteogenic activity of PDLSCs. Hesperetin scavenged intracellular reactive oxygen species (ROS) produced under high glucose condition. Furthermore, hesperetin increased the activity of the PI3K/Akt and β-catenin pathways. Consistent with this, blockage of Akt or β-catenin diminished the protective effect of hesperetin against high glucose-inhibited osteogenic differentiation. Collectively, our results suggest that hesperetin alleviates the high glucose-mediated suppression of osteogenic differentiation in PDLSCs by regulating ROS levels and the PI3K/Akt and β-catenin signaling pathways." @default.
- W2083583313 created "2016-06-24" @default.
- W2083583313 creator A5034271738 @default.
- W2083583313 creator A5039729820 @default.
- W2083583313 creator A5044518854 @default.
- W2083583313 creator A5064483791 @default.
- W2083583313 creator A5071928897 @default.
- W2083583313 creator A5077808295 @default.
- W2083583313 date "2013-06-28" @default.
- W2083583313 modified "2023-10-03" @default.
- W2083583313 title "Hesperetin Alleviates the Inhibitory Effects of High Glucose on the Osteoblastic Differentiation of Periodontal Ligament Stem Cells" @default.
- W2083583313 cites W1783616538 @default.
- W2083583313 cites W1965119043 @default.
- W2083583313 cites W1973957009 @default.
- W2083583313 cites W1976298200 @default.
- W2083583313 cites W1983919104 @default.
- W2083583313 cites W1983963835 @default.
- W2083583313 cites W1993910454 @default.
- W2083583313 cites W1996086418 @default.
- W2083583313 cites W2006927962 @default.
- W2083583313 cites W2007755644 @default.
- W2083583313 cites W2008929124 @default.
- W2083583313 cites W2021470201 @default.
- W2083583313 cites W2026008427 @default.
- W2083583313 cites W2031226728 @default.
- W2083583313 cites W2031269763 @default.
- W2083583313 cites W2036431532 @default.
- W2083583313 cites W2039348615 @default.
- W2083583313 cites W2048480904 @default.
- W2083583313 cites W2053399811 @default.
- W2083583313 cites W2053543161 @default.
- W2083583313 cites W2055823811 @default.
- W2083583313 cites W2060503160 @default.
- W2083583313 cites W2061155330 @default.
- W2083583313 cites W2067235336 @default.
- W2083583313 cites W2073772438 @default.
- W2083583313 cites W2086067126 @default.
- W2083583313 cites W2094076414 @default.
- W2083583313 cites W2096240275 @default.
- W2083583313 cites W2096756743 @default.
- W2083583313 cites W2106110407 @default.
- W2083583313 cites W2116316981 @default.
- W2083583313 cites W2116864112 @default.
- W2083583313 cites W2122361297 @default.
- W2083583313 cites W2127114287 @default.
- W2083583313 cites W2130516299 @default.
- W2083583313 cites W2137563421 @default.
- W2083583313 cites W2144224215 @default.
- W2083583313 cites W2161509243 @default.
- W2083583313 cites W2168604354 @default.
- W2083583313 cites W2329516277 @default.
- W2083583313 cites W4210956735 @default.
- W2083583313 cites W4293247451 @default.
- W2083583313 doi "https://doi.org/10.1371/journal.pone.0067504" @default.
- W2083583313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3696082" @default.
- W2083583313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23840726" @default.
- W2083583313 hasPublicationYear "2013" @default.
- W2083583313 type Work @default.
- W2083583313 sameAs 2083583313 @default.
- W2083583313 citedByCount "51" @default.
- W2083583313 countsByYear W20835833132014 @default.
- W2083583313 countsByYear W20835833132015 @default.
- W2083583313 countsByYear W20835833132016 @default.
- W2083583313 countsByYear W20835833132017 @default.
- W2083583313 countsByYear W20835833132018 @default.
- W2083583313 countsByYear W20835833132019 @default.
- W2083583313 countsByYear W20835833132020 @default.
- W2083583313 countsByYear W20835833132021 @default.
- W2083583313 countsByYear W20835833132022 @default.
- W2083583313 countsByYear W20835833132023 @default.
- W2083583313 crossrefType "journal-article" @default.
- W2083583313 hasAuthorship W2083583313A5034271738 @default.
- W2083583313 hasAuthorship W2083583313A5039729820 @default.
- W2083583313 hasAuthorship W2083583313A5044518854 @default.
- W2083583313 hasAuthorship W2083583313A5064483791 @default.
- W2083583313 hasAuthorship W2083583313A5071928897 @default.
- W2083583313 hasAuthorship W2083583313A5077808295 @default.
- W2083583313 hasBestOaLocation W20835833131 @default.
- W2083583313 hasConcept C142724271 @default.
- W2083583313 hasConcept C160160445 @default.
- W2083583313 hasConcept C181199279 @default.
- W2083583313 hasConcept C185592680 @default.
- W2083583313 hasConcept C202751555 @default.
- W2083583313 hasConcept C204787440 @default.
- W2083583313 hasConcept C2776128092 @default.
- W2083583313 hasConcept C2776363554 @default.
- W2083583313 hasConcept C2777252647 @default.
- W2083583313 hasConcept C2778004101 @default.
- W2083583313 hasConcept C2778260815 @default.
- W2083583313 hasConcept C2779054382 @default.
- W2083583313 hasConcept C2779886569 @default.
- W2083583313 hasConcept C55493867 @default.
- W2083583313 hasConcept C71924100 @default.
- W2083583313 hasConcept C86803240 @default.
- W2083583313 hasConcept C95444343 @default.
- W2083583313 hasConceptScore W2083583313C142724271 @default.
- W2083583313 hasConceptScore W2083583313C160160445 @default.
- W2083583313 hasConceptScore W2083583313C181199279 @default.