Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083598272> ?p ?o ?g. }
- W2083598272 endingPage "1361" @default.
- W2083598272 startingPage "1351" @default.
- W2083598272 abstract "Transforming growth factor (TGF)-β can suppress and promote breast cancer progression. How TGF-β elicits these dichotomous functions and which roles the principle intracellular effector proteins Smad2 and Smad3 have therein, is unclear. Here, we investigated the specific functions of Smad2 and Smad3 in TGF-β-induced responses in breast cancer cells in vitro and in a mouse model for breast cancer metastasis. We stably knocked down Smad2 or Smad3 expression in MDA-MB-231 breast cancer cells. The TGF-β-induced Smad3-mediated transcriptional response was mitigated and enhanced by Smad3 and Smad2 knockdown, respectively. This response was also seen for TGF-β-induced vascular endothelial growth factor (VEGF) expression. TGF-β induction of key target genes involved in bone metastasis, were found to be dependent on Smad3 but not Smad2. Strikingly, whereas knockdown of Smad3 in MDA-MB-231 resulted in prolonged latency and delayed growth of bone metastasis, Smad2 knockdown resulted in a more aggressive phenotype compared with control MDA-MB-231 cells. Consistent with differential effects of Smad knockdown on TGF-β-induced VEGF expression, these opposing effects of Smad2 versus Smad3 could be directly correlated with divergence in the regulation of tumor angiogenesis in vivo. Thus, Smad2 and Smad3 differentially affect breast cancer bone metastasis formation in vivo." @default.
- W2083598272 created "2016-06-24" @default.
- W2083598272 creator A5022472685 @default.
- W2083598272 creator A5042155192 @default.
- W2083598272 creator A5043961039 @default.
- W2083598272 creator A5046914597 @default.
- W2083598272 creator A5051606725 @default.
- W2083598272 creator A5082975435 @default.
- W2083598272 creator A5083709043 @default.
- W2083598272 date "2009-12-14" @default.
- W2083598272 modified "2023-10-11" @default.
- W2083598272 title "Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis" @default.
- W2083598272 cites W1487581481 @default.
- W2083598272 cites W1514397065 @default.
- W2083598272 cites W1528120845 @default.
- W2083598272 cites W1967600348 @default.
- W2083598272 cites W1978146894 @default.
- W2083598272 cites W1986471913 @default.
- W2083598272 cites W1989052193 @default.
- W2083598272 cites W1996046117 @default.
- W2083598272 cites W2000099153 @default.
- W2083598272 cites W2014584180 @default.
- W2083598272 cites W2026428548 @default.
- W2083598272 cites W2027636469 @default.
- W2083598272 cites W2028476252 @default.
- W2083598272 cites W2034552950 @default.
- W2083598272 cites W2041154504 @default.
- W2083598272 cites W2048654496 @default.
- W2083598272 cites W2049861779 @default.
- W2083598272 cites W2052982753 @default.
- W2083598272 cites W2058195928 @default.
- W2083598272 cites W2059174198 @default.
- W2083598272 cites W2060315334 @default.
- W2083598272 cites W2062074088 @default.
- W2083598272 cites W2063076489 @default.
- W2083598272 cites W2066419333 @default.
- W2083598272 cites W2069642304 @default.
- W2083598272 cites W2089078929 @default.
- W2083598272 cites W2094632087 @default.
- W2083598272 cites W2095461768 @default.
- W2083598272 cites W2095605427 @default.
- W2083598272 cites W2096662041 @default.
- W2083598272 cites W2110643890 @default.
- W2083598272 cites W2116403488 @default.
- W2083598272 cites W2119807946 @default.
- W2083598272 cites W2121946269 @default.
- W2083598272 cites W2124281312 @default.
- W2083598272 cites W2124836729 @default.
- W2083598272 cites W2136280424 @default.
- W2083598272 cites W2140088548 @default.
- W2083598272 cites W2143303692 @default.
- W2083598272 cites W2147610258 @default.
- W2083598272 cites W2152247435 @default.
- W2083598272 cites W2159000413 @default.
- W2083598272 cites W2167030358 @default.
- W2083598272 cites W4229714030 @default.
- W2083598272 doi "https://doi.org/10.1038/onc.2009.426" @default.
- W2083598272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20010874" @default.
- W2083598272 hasPublicationYear "2009" @default.
- W2083598272 type Work @default.
- W2083598272 sameAs 2083598272 @default.
- W2083598272 citedByCount "158" @default.
- W2083598272 countsByYear W20835982722012 @default.
- W2083598272 countsByYear W20835982722013 @default.
- W2083598272 countsByYear W20835982722014 @default.
- W2083598272 countsByYear W20835982722015 @default.
- W2083598272 countsByYear W20835982722016 @default.
- W2083598272 countsByYear W20835982722017 @default.
- W2083598272 countsByYear W20835982722018 @default.
- W2083598272 countsByYear W20835982722019 @default.
- W2083598272 countsByYear W20835982722020 @default.
- W2083598272 countsByYear W20835982722021 @default.
- W2083598272 countsByYear W20835982722022 @default.
- W2083598272 countsByYear W20835982722023 @default.
- W2083598272 crossrefType "journal-article" @default.
- W2083598272 hasAuthorship W2083598272A5022472685 @default.
- W2083598272 hasAuthorship W2083598272A5042155192 @default.
- W2083598272 hasAuthorship W2083598272A5043961039 @default.
- W2083598272 hasAuthorship W2083598272A5046914597 @default.
- W2083598272 hasAuthorship W2083598272A5051606725 @default.
- W2083598272 hasAuthorship W2083598272A5082975435 @default.
- W2083598272 hasAuthorship W2083598272A5083709043 @default.
- W2083598272 hasBestOaLocation W20835982721 @default.
- W2083598272 hasConcept C118131993 @default.
- W2083598272 hasConcept C121608353 @default.
- W2083598272 hasConcept C134018914 @default.
- W2083598272 hasConcept C173396325 @default.
- W2083598272 hasConcept C2777783956 @default.
- W2083598272 hasConcept C2778229498 @default.
- W2083598272 hasConcept C2779013556 @default.
- W2083598272 hasConcept C2780394083 @default.
- W2083598272 hasConcept C2781080636 @default.
- W2083598272 hasConcept C502942594 @default.
- W2083598272 hasConcept C530470458 @default.
- W2083598272 hasConcept C54355233 @default.
- W2083598272 hasConcept C81885089 @default.
- W2083598272 hasConcept C86803240 @default.
- W2083598272 hasConceptScore W2083598272C118131993 @default.