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- W2083617209 abstract "Following 400 mg brodimoprim given orally to 8 volunteers, the peaks of the mean concentration curves were 3.2 ± 1.0 mg/1 in serum and 1.0 ± 0.2 mg/1 ( ± SEM) in skin blister fluid. The terminal half-lives were 25.9 ± 2.2 h and 42.2 ± 6.5 h in serum and blister fluid, respectively. The area under the concentration-versus-time curve for blister fluid was 73 % of serum value, and the mean recovery of bioactive drug in urine during 24 h was 3.4%. Considering the minimal inhibitory concentrations of potential target organisms and the slow elimination, the results suggest that brodimoprim may be useful in the treatment of infections, and that dosage once a day may be sufficient." @default.
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- W2083617209 date "1985-01-01" @default.
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- W2083617209 title "Pharmacokinetics of Brodimoprim in Serum and Skin Blister Fluid" @default.
- W2083617209 doi "https://doi.org/10.1159/000238367" @default.
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