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- W2083619095 abstract "Detection of cerebral β-amyloid (Aβ) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Aβ imaging agents. To further explore their potency as (19)F MRI contrast agents we synthetized several novel fluorinated bis-styrylbenzenes and studied their fluorescent properties and amyloid-β binding characteristics. The compounds showed a high affinity for Aβ plaques on murine and human brain sections. Interestingly, competitive binding experiments demonstrated that they bound to a different binding site than chrysamine G. Despite their high logP values, many bis-styrylbenzenes were able to enter the brain and label murine amyloid in vivo. Unfortunately initial post-mortem (19)F NMR studies showed that these compounds as yet do not warrant further MRI studies due to the reduction of the (19)F signal in the environment of the brain." @default.
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- W2083619095 date "2014-04-15" @default.
- W2083619095 modified "2023-09-26" @default.
- W2083619095 title "Polyfluorinated bis-styrylbenzenes as amyloid-β plaque binding ligands." @default.
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- W2083619095 doi "https://doi.org/10.1016/j.bmc.2014.02.054" @default.
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