Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083638416> ?p ?o ?g. }
- W2083638416 endingPage "4677" @default.
- W2083638416 startingPage "4664" @default.
- W2083638416 abstract "The mechanical overloading of cartilage is involved in the pathophysiology of osteoarthritis (OA) by both biochemical and mechanical pathways. The application of fluid shear stress to chondrocytes recapitulates the earmarks of OA, as evidenced by the release of proinflammatory cytokines (PICs), matrix metalloproteinases (MMPs), and apoptotic factors. Dysregulations or mutations in these genes might directly cause OA in addition to determining the stage at which OA becomes apparent, the joint sites involved, and the severity of the disease and how rapidly it progresses. However, the underlying mechanisms remain unknown. In this review, we propose that the dysregulation of cyclooxygenase-2 (COX-2) is associated with fluid shear stress-induced OA via its metabolic products at different stages of the disease. Indeed, high fluid shear stress rapidly induces the production of PICs and MMPs via COX-2-derived prostaglandin (PG)E2 at the early stage of OA. In contrast, prolonged shear exposure (>12 h) aggravates the condition by concurrently up-regulating the expression of proapoptotic genes and down-regulating the expression of antiapoptotic genes in a 15-deoxy-Δ (12,14)-prostaglandin J2 (15d-PGJ2)-dependent manner at the late stage of disease. These observations may help to resolve long-standing questions in OA progression and provide insight for development of strategies to treat and combat OA." @default.
- W2083638416 created "2016-06-24" @default.
- W2083638416 creator A5009930001 @default.
- W2083638416 creator A5040899817 @default.
- W2083638416 creator A5049898092 @default.
- W2083638416 creator A5071452908 @default.
- W2083638416 creator A5076772309 @default.
- W2083638416 creator A5078814903 @default.
- W2083638416 date "2013-08-20" @default.
- W2083638416 modified "2023-10-16" @default.
- W2083638416 title "Fluid shear stress‐induced osteoarthritis: roles of cyclooxygenase‐2 and its metabolic products in inducing the expression of proinflammatory cytokines and matrix metalloproteinases" @default.
- W2083638416 cites W1495556840 @default.
- W2083638416 cites W1539392991 @default.
- W2083638416 cites W1565533401 @default.
- W2083638416 cites W1592997265 @default.
- W2083638416 cites W1852647106 @default.
- W2083638416 cites W1897201563 @default.
- W2083638416 cites W1964073342 @default.
- W2083638416 cites W1966180339 @default.
- W2083638416 cites W1968021703 @default.
- W2083638416 cites W1978025097 @default.
- W2083638416 cites W1979564777 @default.
- W2083638416 cites W1979600880 @default.
- W2083638416 cites W1979972616 @default.
- W2083638416 cites W1985385208 @default.
- W2083638416 cites W1985477860 @default.
- W2083638416 cites W1989469359 @default.
- W2083638416 cites W1989948125 @default.
- W2083638416 cites W1992724479 @default.
- W2083638416 cites W1993963021 @default.
- W2083638416 cites W2000165895 @default.
- W2083638416 cites W2001825870 @default.
- W2083638416 cites W2004065216 @default.
- W2083638416 cites W2005832407 @default.
- W2083638416 cites W2006537480 @default.
- W2083638416 cites W2008386900 @default.
- W2083638416 cites W2008540611 @default.
- W2083638416 cites W2010802338 @default.
- W2083638416 cites W2012375609 @default.
- W2083638416 cites W2016211178 @default.
- W2083638416 cites W2017720269 @default.
- W2083638416 cites W2019400588 @default.
- W2083638416 cites W2019449067 @default.
- W2083638416 cites W2019901635 @default.
- W2083638416 cites W2022640830 @default.
- W2083638416 cites W2026802983 @default.
- W2083638416 cites W2029322332 @default.
- W2083638416 cites W2030805052 @default.
- W2083638416 cites W2033701197 @default.
- W2083638416 cites W2036175192 @default.
- W2083638416 cites W2036834425 @default.
- W2083638416 cites W2037174379 @default.
- W2083638416 cites W2042469661 @default.
- W2083638416 cites W2045994102 @default.
- W2083638416 cites W2053342448 @default.
- W2083638416 cites W2055361189 @default.
- W2083638416 cites W2061690937 @default.
- W2083638416 cites W2062676485 @default.
- W2083638416 cites W2063347675 @default.
- W2083638416 cites W2064410171 @default.
- W2083638416 cites W2066974794 @default.
- W2083638416 cites W2068864388 @default.
- W2083638416 cites W2070686036 @default.
- W2083638416 cites W2072652175 @default.
- W2083638416 cites W2072960798 @default.
- W2083638416 cites W2075255950 @default.
- W2083638416 cites W2076233136 @default.
- W2083638416 cites W2078828283 @default.
- W2083638416 cites W2080839318 @default.
- W2083638416 cites W2082964054 @default.
- W2083638416 cites W2085268667 @default.
- W2083638416 cites W2086096794 @default.
- W2083638416 cites W2087175325 @default.
- W2083638416 cites W2088752908 @default.
- W2083638416 cites W2091437415 @default.
- W2083638416 cites W2091704534 @default.
- W2083638416 cites W2091795087 @default.
- W2083638416 cites W2096064303 @default.
- W2083638416 cites W2097073034 @default.
- W2083638416 cites W2103145683 @default.
- W2083638416 cites W2113683216 @default.
- W2083638416 cites W2115050343 @default.
- W2083638416 cites W2115824889 @default.
- W2083638416 cites W2119887587 @default.
- W2083638416 cites W2131400044 @default.
- W2083638416 cites W2132411378 @default.
- W2083638416 cites W2140215285 @default.
- W2083638416 cites W2148786141 @default.
- W2083638416 cites W2153429684 @default.
- W2083638416 cites W2155247533 @default.
- W2083638416 cites W2163069065 @default.
- W2083638416 cites W2166622593 @default.
- W2083638416 cites W2168424633 @default.
- W2083638416 cites W2409522037 @default.
- W2083638416 cites W4231070606 @default.
- W2083638416 cites W4247473588 @default.
- W2083638416 cites W4313050937 @default.
- W2083638416 doi "https://doi.org/10.1096/fj.13-234542" @default.