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- W2083669405 abstract "Human neuroblastoma cells contain a 260 kDa surface-associated antigen (NB-p260) that is recognised by natural cytotoxic IgM antibodies. In this study we demonstrate that NB-p260 is expressed in vivo in a neuroblastoma tumour specimen but not in normal human tissues of neuronal origin. Since MYCN amplification is a clinical marker of neuroblastoma disease progression, we analysed the expression of NB-p260 in human neuroblastoma cell lines with different MYCN amplification status. However, both amplified and non-amplified neuroblastoma cell lines exhibited comparable NB-p260 expression. Treatment of neuroblastoma cells with the differentiation-inducing agent retinoic acid (RA) also had no effect on the expression of NB-p260. Collectively, the data suggest that expression of NB-p260 on human neuroblastoma cells is independent of malignancy and differentiation status of neuroblastoma." @default.
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- W2083669405 date "1997-10-01" @default.
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- W2083669405 title "Expression of a 260kDa Neuroblastoma Surface Antigen, the Target of Cytotoxic Natural Human IgM: Correlation to MYCN Amplification and Effects of Retinoic Acid" @default.
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- W2083669405 doi "https://doi.org/10.1016/s0959-8049(97)00207-4" @default.
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