Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083669410> ?p ?o ?g. }
- W2083669410 endingPage "139" @default.
- W2083669410 startingPage "132" @default.
- W2083669410 abstract "Recently identified candidate susceptibility genes for schizophrenia are likely to play, important roles in the pathophysiology of the illness. It is also clear, however, that the etiologic, contribution of these genes is not only via their own functions but also through interactions with other, genes and environmental factors. Genetic, transgenic and postmortem brain studies support a, potential role for NRG1–erbB4 signaling in schizophrenia. Embedded in the results of these studies, however, are clues to the notion that NRG1–erbB4 signaling does not act alone but in conjunction with, other pathways. This article aims to re-evaluate the evidence for the role of neuregulin 1 (NRG1)–erbB4 signaling in schizophrenia by focusing on its interactions with other candidate susceptibility, pathways. In addition, we consider molecular substrates upon which the NRG1–erbB4 and other, candidate pathways converge contributing to susceptibility for the illness (schizophrenia interactome). Glutamatergic signaling can be an interesting candidate for schizophrenia interactome. Schizophrenia is associated with NMDA receptor hypofunction and moreover, several susceptibility genes for, schizophrenia converge on NMDA receptor signaling. These candidate genes influence NMDA receptor, signaling via diverse mechanisms, yet all eventually impact on protein composition of NMDA receptor, complexes. Likewise, the protein associations in the receptor complexes can themselves modulate, signaling molecules of candidate genes and their pathways. Therefore, protein–protein interactions in the NMDA receptor complexes can mediate reciprocal interactions between NMDA receptor function, and susceptibility candidate pathways including NRG1–erbB4 signaling and thus can be a, schizophrenia interactome." @default.
- W2083669410 created "2016-06-24" @default.
- W2083669410 creator A5019955038 @default.
- W2083669410 creator A5035834560 @default.
- W2083669410 creator A5060876408 @default.
- W2083669410 creator A5036186750 @default.
- W2083669410 date "2010-09-01" @default.
- W2083669410 modified "2023-10-16" @default.
- W2083669410 title "Neuregulin 1–erbB4 pathway in schizophrenia: From genes to an interactome" @default.
- W2083669410 cites W1508668327 @default.
- W2083669410 cites W1532915946 @default.
- W2083669410 cites W1549069263 @default.
- W2083669410 cites W1576792925 @default.
- W2083669410 cites W1583412938 @default.
- W2083669410 cites W1967364883 @default.
- W2083669410 cites W1969572960 @default.
- W2083669410 cites W1974992252 @default.
- W2083669410 cites W1975599306 @default.
- W2083669410 cites W1977768257 @default.
- W2083669410 cites W1978564492 @default.
- W2083669410 cites W1979791151 @default.
- W2083669410 cites W1980073907 @default.
- W2083669410 cites W1980141913 @default.
- W2083669410 cites W1980967004 @default.
- W2083669410 cites W1981437105 @default.
- W2083669410 cites W1981473462 @default.
- W2083669410 cites W1985900119 @default.
- W2083669410 cites W1989278867 @default.
- W2083669410 cites W1995540460 @default.
- W2083669410 cites W1995959193 @default.
- W2083669410 cites W1997031801 @default.
- W2083669410 cites W1999356943 @default.
- W2083669410 cites W2001618399 @default.
- W2083669410 cites W2001837017 @default.
- W2083669410 cites W2007492904 @default.
- W2083669410 cites W2009307684 @default.
- W2083669410 cites W2009424285 @default.
- W2083669410 cites W2011573205 @default.
- W2083669410 cites W2011818792 @default.
- W2083669410 cites W2012203059 @default.
- W2083669410 cites W2014141616 @default.
- W2083669410 cites W2014847766 @default.
- W2083669410 cites W2016717347 @default.
- W2083669410 cites W2017498093 @default.
- W2083669410 cites W2018912242 @default.
- W2083669410 cites W2019184486 @default.
- W2083669410 cites W2019797166 @default.
- W2083669410 cites W2020145862 @default.
- W2083669410 cites W2020237866 @default.
- W2083669410 cites W2021168080 @default.
- W2083669410 cites W2023368138 @default.
- W2083669410 cites W2025953513 @default.
- W2083669410 cites W2026721396 @default.
- W2083669410 cites W2030756376 @default.
- W2083669410 cites W2034802813 @default.
- W2083669410 cites W2034995368 @default.
- W2083669410 cites W2035909968 @default.
- W2083669410 cites W2036146366 @default.
- W2083669410 cites W2037091931 @default.
- W2083669410 cites W2038661578 @default.
- W2083669410 cites W2043212123 @default.
- W2083669410 cites W2043345702 @default.
- W2083669410 cites W2043467783 @default.
- W2083669410 cites W2047007360 @default.
- W2083669410 cites W2047560376 @default.
- W2083669410 cites W2049733177 @default.
- W2083669410 cites W2063273481 @default.
- W2083669410 cites W2063619823 @default.
- W2083669410 cites W2063978545 @default.
- W2083669410 cites W2066635264 @default.
- W2083669410 cites W2066700676 @default.
- W2083669410 cites W2069433703 @default.
- W2083669410 cites W2070739681 @default.
- W2083669410 cites W2071090720 @default.
- W2083669410 cites W2074078151 @default.
- W2083669410 cites W2075300079 @default.
- W2083669410 cites W2080396204 @default.
- W2083669410 cites W2084200464 @default.
- W2083669410 cites W2085062703 @default.
- W2083669410 cites W2085778323 @default.
- W2083669410 cites W2088337416 @default.
- W2083669410 cites W2089762801 @default.
- W2083669410 cites W2090409162 @default.
- W2083669410 cites W2090982878 @default.
- W2083669410 cites W2092250372 @default.
- W2083669410 cites W2097333356 @default.
- W2083669410 cites W2097364564 @default.
- W2083669410 cites W2099698491 @default.
- W2083669410 cites W2104079955 @default.
- W2083669410 cites W2106028122 @default.
- W2083669410 cites W2106584815 @default.
- W2083669410 cites W2106785307 @default.
- W2083669410 cites W2107427447 @default.
- W2083669410 cites W2107616280 @default.
- W2083669410 cites W2108422856 @default.
- W2083669410 cites W2114381854 @default.
- W2083669410 cites W2116774419 @default.
- W2083669410 cites W2123029057 @default.