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• W2083670951 endingPage "275" @default.
• W2083670951 startingPage "266" @default.
• W2083670951 abstract "Photodynamic therapy (PDT) is a relatively new method to treat various kinds of tumors, including those of the oral cavity. The topical 5-ALA-PDT treatment for tumors of the oral mucosa is preferred, since when administered systemically, there is a general photosensitization drawback in the patient. However, 5-ALA is a hydrophilic molecule and its penetration and retention is limited by topical route, including oral mucosa. We propose a topical delivery system of chitosan-based mucoadhesive film, aiming to promote greater retention of 5-ALA in tissue. The chitosan (CHT) films (4% w/w) were prepared using the solvent evaporation/casting technique. They were tested without 5-ALA resulting in permeability to water vapor (W.V.P = 2.15–8.54 g mm/(h cm2 Pa) swelling ∼300.0% (±10.5) at 4 h or 24 h and in vitro residence time >24 h for all tests. CHT films containing 10.0% (w/w) 5-ALA have resulted in average weight of 0.22 g and thickness of 0.608 mm as suitable characteristics for oral application. In the presence of CHT films both in vitro permeation and retention of 5-ALA (1.0% or 10.0%) were increased. However, 10.0% 5-ALA presented highest values of permeation and retention (∼4 and 17 times respectively, compared to propylene glycol vehicle). On the other hand, in vitro mucoadhesion of CHT films was decreased (18.2-fold and 3.1-fold) by 5-ALA addition (1.0% or 10.0% respectively). However, CHT film containing 10.0% of 5-ALA can be a potential delivery system for topical use in the treatment of tumors of the oral cavity using PDT because it favored the retention of 5-ALA in this tissue and has shown convenient mucoadhesion." @default.
• W2083670951 created "2016-06-24" @default.
• W2083670951 creator A5025490261 @default.
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• W2083670951 date "2014-11-01" @default.
• W2083670951 modified "2023-10-16" @default.
• W2083670951 title "Chitosan-based mucoadhesive films containing 5-aminolevulinic acid for buccal cancer’s treatment" @default.
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• W2083670951 doi "https://doi.org/10.1016/j.jphotobiol.2014.08.005" @default.
• W2083670951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25190225" @default.
• W2083670951 hasPublicationYear "2014" @default.
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