FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083670993> ?p ?o ?g. }

• W2083670993 abstract "High levels of plasma total homocysteine (tHcy) are involved in arterial or venous occlusive diseases. It essentially depends on the nutritional status of folic acid (FA) and vitamins B12 or B6, but also on the methylenetetrahydrofolate reductase (MTHFR) enzymatic activity. We aim to evaluate the response of the hyperhomocysteinemia (HHcy) to a standard schedule of vitamin supplementation, according with the MTHFR genotype.227 patients, diagnosed with venous thromboembolism (VTE) were analysed for tHcy (in fasting conditions), and for the MTHFR-C677T gene polymorphism. When the tHcy exceeded the cut-off point (men = 16, women = 15 mumol/l), the patients were supplemented with a dose equivalent to 1 mg FA, 0.2 mg B12 and 100 mg of B6, daily by 6 weeks. Afterwards they were reanalysed and the reduction was stratified by MTHFR genotype, looking for any difference in the response.The mean fasting tHcy was 12.3 mumol/l (SD = 8). The 51 hyperhomocysteinemic patients (22%) were older (65.1 y) than the normal ones (55.0 y) (p = 0.0001). The treatment was carried out properly in 46 patients (90%). The pre-treatment mean Hcy was 23.2 (SD = 10.5) mumol/l, and it was reduced to 13.0 (SD = 5.9) (p = 0.0001) (mean reduction = 42.1%). By genotype, the C/C reduced from 21.0 to 13.2 mumol/l (37%) (n = 18), the C/T from 25.0 to 12.6 mumol/l (46%) (n = 24), and the abnormal homozygotes T/T from 22.7 to 14.5 mumol/l (39%) (n = 4), although no statistical significant differences were found. In 80% of cases (37/46), tHcy values normalised. A negative correlation (r = -0.471) (p = 0.005) was observed between age and response.The FA/B6/B12 based therapy reduces in a simple, quick and effective way (> 40% in 6 weeks) the pathologic tHcy levels on a VTE population and this is not influenced by the MTHFR genotype. As HHcy seems related with recurrences of venous thrombosis, we could speculate if it would be useful to analyse routinely the tHcy, attempting reduction in selected cases." @default.
• W2083670993 created "2016-06-24" @default.
• W2083670993 creator A5019045461 @default.
• W2083670993 creator A5022270402 @default.
• W2083670993 creator A5040751299 @default.
• W2083670993 creator A5040969669 @default.
• W2083670993 creator A5045739482 @default.
• W2083670993 creator A5072565876 @default.
• W2083670993 creator A5080003977 @default.
• W2083670993 date "2000-01-01" @default.
• W2083670993 modified "2023-10-18" @default.
• W2083670993 title "Reducción de concentraciones elevadas de homocisteína con ácido fólico y vitaminas B en pacientes con tromboembolia venosa: relación entre respuesta y genotipo C677T de la metilén tetrahidrofólico reductasa (MTHFR)" @default.
• W2083670993 cites W1482397881 @default.
• W2083670993 cites W149972145 @default.
• W2083670993 cites W1500962797 @default.
• W2083670993 cites W1763958285 @default.
• W2083670993 cites W1853715951 @default.
• W2083670993 cites W1912753018 @default.
• W2083670993 cites W1918125325 @default.
• W2083670993 cites W1966202709 @default.
• W2083670993 cites W1975357252 @default.
• W2083670993 cites W1982894405 @default.
• W2083670993 cites W1989790579 @default.
• W2083670993 cites W1990926399 @default.
• W2083670993 cites W1995781460 @default.
• W2083670993 cites W1998033890 @default.
• W2083670993 cites W2014205090 @default.
• W2083670993 cites W2024122285 @default.
• W2083670993 cites W2031857836 @default.
• W2083670993 cites W2049381991 @default.
• W2083670993 cites W2050411238 @default.
• W2083670993 cites W2066688265 @default.
• W2083670993 cites W2069487228 @default.
• W2083670993 cites W2079604516 @default.
• W2083670993 cites W2089205356 @default.
• W2083670993 cites W2089793520 @default.
• W2083670993 cites W2112227680 @default.
• W2083670993 cites W2119262508 @default.
• W2083670993 cites W2125756592 @default.
• W2083670993 cites W2126486540 @default.
• W2083670993 cites W2131601973 @default.
• W2083670993 cites W2144139061 @default.
• W2083670993 cites W2151667576 @default.
• W2083670993 cites W2165715420 @default.
• W2083670993 cites W2166278013 @default.
• W2083670993 cites W2172568439 @default.
• W2083670993 cites W2173348934 @default.
• W2083670993 cites W2317172136 @default.
• W2083670993 cites W2319326268 @default.
• W2083670993 cites W2321554768 @default.
• W2083670993 cites W2337184574 @default.
• W2083670993 cites W2403895423 @default.
• W2083670993 cites W2416929543 @default.
• W2083670993 cites W1708861499 @default.
• W2083670993 doi "https://doi.org/10.1016/s0025-7753(00)71172-9" @default.
• W2083670993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10782453" @default.
• W2083670993 hasPublicationYear "2000" @default.
• W2083670993 type Work @default.
• W2083670993 sameAs 2083670993 @default.
• W2083670993 citedByCount "10" @default.
• W2083670993 crossrefType "journal-article" @default.
• W2083670993 hasAuthorship W2083670993A5019045461 @default.
• W2083670993 hasAuthorship W2083670993A5022270402 @default.
• W2083670993 hasAuthorship W2083670993A5040751299 @default.
• W2083670993 hasAuthorship W2083670993A5040969669 @default.
• W2083670993 hasAuthorship W2083670993A5045739482 @default.
• W2083670993 hasAuthorship W2083670993A5072565876 @default.
• W2083670993 hasAuthorship W2083670993A5080003977 @default.
• W2083670993 hasConcept C104317684 @default.
• W2083670993 hasConcept C126322002 @default.
• W2083670993 hasConcept C134018914 @default.
• W2083670993 hasConcept C135763542 @default.
• W2083670993 hasConcept C185592680 @default.
• W2083670993 hasConcept C2776523773 @default.
• W2083670993 hasConcept C2777090595 @default.
• W2083670993 hasConcept C2992130864 @default.
• W2083670993 hasConcept C43563269 @default.
• W2083670993 hasConcept C55493867 @default.
• W2083670993 hasConcept C71924100 @default.
• W2083670993 hasConcept C90924648 @default.
• W2083670993 hasConceptScore W2083670993C104317684 @default.
• W2083670993 hasConceptScore W2083670993C126322002 @default.
• W2083670993 hasConceptScore W2083670993C134018914 @default.
• W2083670993 hasConceptScore W2083670993C135763542 @default.
• W2083670993 hasConceptScore W2083670993C185592680 @default.
• W2083670993 hasConceptScore W2083670993C2776523773 @default.
• W2083670993 hasConceptScore W2083670993C2777090595 @default.
• W2083670993 hasConceptScore W2083670993C2992130864 @default.
• W2083670993 hasConceptScore W2083670993C43563269 @default.
• W2083670993 hasConceptScore W2083670993C55493867 @default.
• W2083670993 hasConceptScore W2083670993C71924100 @default.
• W2083670993 hasConceptScore W2083670993C90924648 @default.
• W2083670993 hasLocation W20836709931 @default.
• W2083670993 hasLocation W20836709932 @default.
• W2083670993 hasOpenAccess W2083670993 @default.
• W2083670993 hasPrimaryLocation W20836709931 @default.
• W2083670993 hasRelatedWork W1939837609 @default.
• W2083670993 hasRelatedWork W1988283092 @default.
• W2083670993 hasRelatedWork W2012827141 @default.
• W2083670993 hasRelatedWork W2032888383 @default.

• next