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• W2083673721 abstract "Summary We report global expression profiling of a uvrY‐ deficient mutant of Photorhabdus luminescens . We found that the regulator moiety of the two‐component regulatory system BarA/UvrY regulated more than 500 target genes coding for functions involved in the synthesis of major compartments and metabolic pathways of the cell. This regulation appeared to be in part indirect as UvrY affected the expression of several regulators. Indeed, the flagellum biosynthesis transcription activator FlhC and the flagella regulon were induced in the absence of UvrY, leading to a hyperflagellated phenotype and an increase in motility and biofilm formation. Two major regulatory systems were also altered: the type 2 quorum‐sensing inducer AI‐2 was activated by UvrY, and the CsrA regulator function appeared to be repressed by the increase of the small‐untranslated RNA csrB , the CsrA activity inhibitor TldD and the chaperonin GroESL. Both through and independently of these systems, UvrY regulated oxidative stress resistance; bioluminescence; iron, sugar and peptide transport; proteases; polyketide synthesis enzymes and nucleobases recycling, related to insect degradation and assimilation by bacteria. As a consequence, the uvrY ‐deficient strain exhibited a decreased killing of insect cells and a reduced growth on insect cells culture, suggesting a UvrY role in the adaptation of P. luminescens inside the insect." @default.
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• W2083673721 date "2008-01-31" @default.
• W2083673721 modified "2023-10-15" @default.
• W2083673721 title "Regulatory role of UvrY in adaptation of <i>Photorhabdus luminescens</i> growth inside the insect" @default.
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• W2083673721 doi "https://doi.org/10.1111/j.1462-2920.2007.01528.x" @default.
• W2083673721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18248456" @default.
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