Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083676460> ?p ?o ?g. }
- W2083676460 endingPage "26" @default.
- W2083676460 startingPage "5" @default.
- W2083676460 abstract "Enzymes containing multi-metal active sites are central to numerous biological processes and, consequently, characterization of their structure and function is a problem of outstanding importance. One of the least-explored groups of enzymes is the hydrolases that contain dinuclear metal centers. These enzymes play key roles in carcinogenesis, tissue repair, and protein degradation processes. In addition, some of these enzymes can catalyze the hydrolysis of phosphorus(V) compounds found in nerve gases and agricultural neurotoxins. The determination of detailed reaction mechanisms for these enzymes is required for the design of highly potent, specific inhibitors that can function as potential pharmaceuticals. Hydrolytic enzymes that contain dinuclear centers can use every first row divalent transition metal ion from manganese to zinc, except copper. In order to understand the role of each metal ion in catalysis and the apparent non-selectivity of these enzymes towards divalent transition metal ions, it is critical that the reaction mechanism of a prototypical system be determined. The aminopeptidase from Aeromonas proteolytica (AAP) is one of the best mechanistically characterized hydrolytic enzymes that contains a dinuclear center and is, therefore, the focus of this review." @default.
- W2083676460 created "2016-06-24" @default.
- W2083676460 creator A5085500409 @default.
- W2083676460 date "2002-10-01" @default.
- W2083676460 modified "2023-10-09" @default.
- W2083676460 title "The aminopeptidase from Aeromonas proteolytica: structure and mechanism of co-catalytic metal centers involved in peptide hydrolysis" @default.
- W2083676460 cites W1188339843 @default.
- W2083676460 cites W1527643427 @default.
- W2083676460 cites W1532179928 @default.
- W2083676460 cites W1542029403 @default.
- W2083676460 cites W1543959669 @default.
- W2083676460 cites W1551973964 @default.
- W2083676460 cites W1557983290 @default.
- W2083676460 cites W1564876674 @default.
- W2083676460 cites W1566040104 @default.
- W2083676460 cites W1571433223 @default.
- W2083676460 cites W1579146824 @default.
- W2083676460 cites W1584566482 @default.
- W2083676460 cites W1594457527 @default.
- W2083676460 cites W1598654182 @default.
- W2083676460 cites W1599984390 @default.
- W2083676460 cites W1703401278 @default.
- W2083676460 cites W1769797432 @default.
- W2083676460 cites W1805898977 @default.
- W2083676460 cites W1891265320 @default.
- W2083676460 cites W195071280 @default.
- W2083676460 cites W1954690293 @default.
- W2083676460 cites W1964120330 @default.
- W2083676460 cites W1965770465 @default.
- W2083676460 cites W1967970315 @default.
- W2083676460 cites W1968185653 @default.
- W2083676460 cites W1968827966 @default.
- W2083676460 cites W1975165348 @default.
- W2083676460 cites W1977011959 @default.
- W2083676460 cites W1979034187 @default.
- W2083676460 cites W1979773824 @default.
- W2083676460 cites W1982945635 @default.
- W2083676460 cites W1985446597 @default.
- W2083676460 cites W1985629369 @default.
- W2083676460 cites W1986894327 @default.
- W2083676460 cites W1990071271 @default.
- W2083676460 cites W1991965319 @default.
- W2083676460 cites W1994103683 @default.
- W2083676460 cites W1994303809 @default.
- W2083676460 cites W1994306371 @default.
- W2083676460 cites W1994335443 @default.
- W2083676460 cites W2001151163 @default.
- W2083676460 cites W2003107936 @default.
- W2083676460 cites W2005377023 @default.
- W2083676460 cites W2005510077 @default.
- W2083676460 cites W2007569442 @default.
- W2083676460 cites W2009037950 @default.
- W2083676460 cites W2015304573 @default.
- W2083676460 cites W2016231322 @default.
- W2083676460 cites W2018837311 @default.
- W2083676460 cites W2020386376 @default.
- W2083676460 cites W2021116136 @default.
- W2083676460 cites W2021770929 @default.
- W2083676460 cites W2028691391 @default.
- W2083676460 cites W2034337315 @default.
- W2083676460 cites W2035861138 @default.
- W2083676460 cites W2038825773 @default.
- W2083676460 cites W2040576732 @default.
- W2083676460 cites W2042614258 @default.
- W2083676460 cites W2043835205 @default.
- W2083676460 cites W2045918025 @default.
- W2083676460 cites W2046137490 @default.
- W2083676460 cites W2047514291 @default.
- W2083676460 cites W2054130568 @default.
- W2083676460 cites W2058381750 @default.
- W2083676460 cites W2059334735 @default.
- W2083676460 cites W2062869162 @default.
- W2083676460 cites W2063567669 @default.
- W2083676460 cites W2064302342 @default.
- W2083676460 cites W2066916400 @default.
- W2083676460 cites W2067763402 @default.
- W2083676460 cites W2073607085 @default.
- W2083676460 cites W2075409852 @default.
- W2083676460 cites W2076675620 @default.
- W2083676460 cites W2076724062 @default.
- W2083676460 cites W2077026966 @default.
- W2083676460 cites W2077294102 @default.
- W2083676460 cites W2078317461 @default.
- W2083676460 cites W2079287378 @default.
- W2083676460 cites W2079943317 @default.
- W2083676460 cites W2080012080 @default.
- W2083676460 cites W2080048885 @default.
- W2083676460 cites W2080722333 @default.
- W2083676460 cites W2081378518 @default.
- W2083676460 cites W2081962393 @default.
- W2083676460 cites W2084399153 @default.
- W2083676460 cites W2085785716 @default.
- W2083676460 cites W2088422782 @default.
- W2083676460 cites W2089459862 @default.
- W2083676460 cites W2089493916 @default.
- W2083676460 cites W2089652428 @default.
- W2083676460 cites W2090133370 @default.
- W2083676460 cites W2090629919 @default.