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• W2083697400 abstract "Proper balance between self-renewal and differentiation of lung-specific progenitors is absolutely required for normal lung morphogenesis/regeneration. Therefore, understanding the behavior of lung epithelial stem/progenitor cells could identify innovative solutions for restoring normal lung morphogenesis and/or regeneration. The Notch inhibitor Numb is a key determinant of asymmetric or symmetric cell division and hence cell fate. Yet Numb proximal-distal expression pattern and symmetric versus asymmetric division are uncharacterized during lung epithelial development. Herein, the authors find that the cell fate determinant Numb is highly expressed and asymmetrically distributed at the apical side of distal epithelial progenitors and segregated to one daughter cell in most mitotic cells. Knocking down Numb in MLE15 epithelial cells significantly increased the number of cells expressing the progenitor cell markers Sox9/Id2. Furthermore, cadherin hole analysis revealed that most distal epithelial stem/progenitor cells in embryonic lungs divide asymmetrically; with their cleavage, planes are predicted to bypass the cadherin hole, resulting in asymmetric distribution of the cadherin hole to the daughter cells. These novel findings provide evidence for asymmetric cell division in distal epithelial stem/progenitor cells of embryonic lungs and a framework for future translationally oriented studies in this area." @default.
• W2083697400 created "2016-06-24" @default.
• W2083697400 creator A5042634877 @default.
• W2083697400 creator A5082423464 @default.
• W2083697400 date "2012-06-19" @default.
• W2083697400 modified "2023-10-16" @default.
• W2083697400 title "Numb Expression and Asymmetric versus Symmetric Cell Division in Distal Embryonic Lung Epithelium" @default.
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• W2083697400 doi "https://doi.org/10.1369/0022155412451582" @default.
• W2083697400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3524558" @default.
• W2083697400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22713487" @default.
• W2083697400 hasPublicationYear "2012" @default.
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