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• W2083705046 endingPage "2313" @default.
• W2083705046 startingPage "2301" @default.
• W2083705046 abstract "It is well documented that macrophages and eosinophils play important roles in normal murine pubertal mammary gland development. Although it is accepted that estrogen (E) and progesterone (P) are key players in mammary gland development, the roles these hormones might play in regulating the actions of leukocytes in that process is an understudied area. We show here that P and E, respectively, induce unique, but overlapping, sets of proinflammatory and angiogenic cytokines and chemokines, in the pubertal female BALB/c mammary gland, as well as induce infiltration of macrophages and eosinophils to the mammary periepithelium. This extends earlier studies showing P induction of proinflammatory products in pubertal and adult mammary epithelial organoids and P-induced in vivo infiltration of leukocytes to the adult mammary periepithelium. Importantly, epidermal growth factor receptor-signaling, which is likely mediated by amphiregulin (Areg), a downstream mediator of E and P, is both necessary and sufficient for both E- and P-induced recruitment of macrophages and eosinophils to the pubertal mammary periepithelium. We further show that receptor activator of nuclear factor κB ligand (RANKL), although not sufficient of itself to cause macrophage and eosinophil recruitment, contributes to an optimal response to P. The potency of Areg is highlighted by the fact that it is sufficient to induce macrophage and eosinophil recruitment at levels equivalent to that induced by either E or P. Our finding of a dominant role for Areg in hormonally induced leukocyte recruitment to the pubertal mammary gland parallels its dominance in regulating ductal outgrowth and its role in P-induced proliferation in the pubertal gland." @default.
• W2083705046 created "2016-06-24" @default.
• W2083705046 creator A5001512334 @default.
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• W2083705046 creator A5089765791 @default.
• W2083705046 date "2014-06-01" @default.
• W2083705046 modified "2023-09-22" @default.
• W2083705046 title "Epidermal Growth Factor Receptor (EGFR) Signaling Is a Key Mediator of Hormone-Induced Leukocyte Infiltration in the Pubertal Female Mammary Gland" @default.
• W2083705046 cites W1488419343 @default.
• W2083705046 cites W1528331455 @default.
• W2083705046 cites W1551337203 @default.
• W2083705046 cites W1563819414 @default.
• W2083705046 cites W1567453654 @default.
• W2083705046 cites W1573437546 @default.
• W2083705046 cites W1584506674 @default.
• W2083705046 cites W1650001464 @default.
• W2083705046 cites W1919166337 @default.
• W2083705046 cites W1933061151 @default.
• W2083705046 cites W1964055102 @default.
• W2083705046 cites W1970078194 @default.
• W2083705046 cites W1972001482 @default.
• W2083705046 cites W1974188582 @default.
• W2083705046 cites W1977289462 @default.
• W2083705046 cites W1978939787 @default.
• W2083705046 cites W1984115097 @default.
• W2083705046 cites W1986736465 @default.
• W2083705046 cites W1987399881 @default.
• W2083705046 cites W1990078228 @default.
• W2083705046 cites W1994439119 @default.
• W2083705046 cites W1995612509 @default.
• W2083705046 cites W1996164746 @default.
• W2083705046 cites W2000236348 @default.
• W2083705046 cites W2001392617 @default.
• W2083705046 cites W2003193394 @default.
• W2083705046 cites W2004633183 @default.
• W2083705046 cites W2007237831 @default.
• W2083705046 cites W2007867222 @default.
• W2083705046 cites W2008658436 @default.
• W2083705046 cites W2008786326 @default.
• W2083705046 cites W2011030679 @default.
• W2083705046 cites W2011387218 @default.
• W2083705046 cites W2012425172 @default.
• W2083705046 cites W2016909880 @default.
• W2083705046 cites W2019803826 @default.
• W2083705046 cites W2037146477 @default.
• W2083705046 cites W2037991788 @default.
• W2083705046 cites W2040541451 @default.
• W2083705046 cites W2041034019 @default.
• W2083705046 cites W2042267093 @default.
• W2083705046 cites W2043614433 @default.
• W2083705046 cites W2044192395 @default.
• W2083705046 cites W2044991100 @default.
• W2083705046 cites W2051320963 @default.
• W2083705046 cites W2051783431 @default.
• W2083705046 cites W2052721892 @default.
• W2083705046 cites W2053448057 @default.
• W2083705046 cites W2055138560 @default.
• W2083705046 cites W2064577372 @default.
• W2083705046 cites W2068031169 @default.
• W2083705046 cites W2070430161 @default.
• W2083705046 cites W2071357739 @default.
• W2083705046 cites W2072595885 @default.
• W2083705046 cites W2073612276 @default.
• W2083705046 cites W2076435017 @default.
• W2083705046 cites W2077359527 @default.
• W2083705046 cites W2082062731 @default.
• W2083705046 cites W2085430804 @default.
• W2083705046 cites W2087560192 @default.
• W2083705046 cites W2090542818 @default.
• W2083705046 cites W2097646128 @default.
• W2083705046 cites W2098282196 @default.
• W2083705046 cites W2098923078 @default.
• W2083705046 cites W2099840919 @default.
• W2083705046 cites W2101175579 @default.
• W2083705046 cites W2103663550 @default.
• W2083705046 cites W2105250575 @default.
• W2083705046 cites W2106710825 @default.
• W2083705046 cites W2126588008 @default.
• W2083705046 cites W2131464730 @default.
• W2083705046 cites W2134055933 @default.
• W2083705046 cites W2134318982 @default.
• W2083705046 cites W2139979263 @default.
• W2083705046 cites W2142454592 @default.
• W2083705046 cites W2142584363 @default.
• W2083705046 cites W2143633028 @default.
• W2083705046 cites W2146934968 @default.
• W2083705046 cites W2151217876 @default.
• W2083705046 cites W2153078549 @default.
• W2083705046 cites W2156626338 @default.
• W2083705046 cites W2161506868 @default.
• W2083705046 cites W2163539931 @default.
• W2083705046 cites W2168339479 @default.
• W2083705046 cites W2168811904 @default.
• W2083705046 cites W2324492479 @default.

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