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• W2083740151 abstract "The deiodinative pathways of T4 and the production of T3 and rT3 were compared in two groups of normal volunteers on physiological T4 replacement. One group was given a normal diet and the second group was fasted up to 15 days. After 1 week of fasting, the mean serum T3 level fell from 140 to 93 ng/dl, and the mean serum rT3 level rose from 51 to 106 ng/dl. No significant change occurred in the group mean serum concentration of TSH or total or free T4. These changes were most marked during the fifth to seventh day of fasting, but recovered partly toward the baseline values during the second week of fasting. The ratio of mean serum T3 to mean serum rT3 was 2.8 before fasting. It diminished to 0.9 after 1 week of fasting and increased to 1.5 after 2 weeks of fasting. In seven control subjects, the MCRs of T4, T3, and rT3 were 1.27 ± 0.24, 24.0 ± 3.6, and 105 ± 13 liters/day · 70 kg, respectively (mean ± sd). The disposal rates of T4, T3, and rT3 were 140 ± 16, 41 ± 5, and 49 ± 12 μg/day·70 kg, respectively. In seven fasting subjects, the MCRs of T4, T3, and rT3 were 0.95 ± 0.17 (P < 0.01), 19.3 ± 3.9 (P < 0.05), and 55 ± 15 liters/day ·70 kg (P < 0.001), whereas the disposal rates of T4, T3( and rT3 were 113 ± 14 (P < 0.005), 17 ± 4 (P < 0.001), and 58 ± 9 μg/day·70 kg (P < 0.2), respectively. The clearance of rT3 was reduced 52%, and the T3 disposal rate was reduced to 41% in the fasting subjects. The mean rT3 disposal rate remained unchanged, but the rT3 disposal to T4 disposal ratio rose from 0.35 to 0.51 during fasting. The T4 to T3 conversion rate was reduced to 50%, and the T4 to rT3 conversion rate was increased to 146% in the fasting group as compared to the control group. The proportion of T4 metabolized by deiodination remained unchanged (77% in the control group and 76% in the fasting group). The results suggest that in subjects of good health, severe caloric deprivation impaired iodothyronine deiodiation in general, and in particular the deiodination at 5′ position, thereby reducing both T3 production and rT3 clearance. Significant shunting of T4 metabolism away from T3 production into rT3 production was noted. Fasting did not alter the proportion of T4 undergoing metabolism via the deiodinative pathways compared to the nondeiodinative pathways." @default.
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• W2083740151 date "1978-12-01" @default.
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• W2083740151 title "The Production and Metabolism of 3,5,3′-Triiodothyronine and 3,3′,5′-Triiodothyronine in Normal and Fasting Subjects*" @default.
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• W2083740151 doi "https://doi.org/10.1210/jcem-47-6-1311" @default.
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