FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083740746> ?p ?o ?g. }

• W2083740746 abstract "Abstract Background Fibroblast growth factors (Fgfs) are important regulators of cerebral cortex development. Fgf2, Fgf8 and Fgf17 promote growth and specification of rostromedial (frontoparietal) cortical areas. Recently, the function of Fgf15 in antagonizing Fgf8 in the rostral signaling center was also reported. However, regulation of caudal area formation by Fgf signaling remains unknown. Results In mutant mice with constitutive activation of Fgf receptor 3 (Fgfr3) in the forebrain, surface area of the caudolateral cortex was markedly expanded at early postnatal stage, while rostromedial surface area remained normal. Cortical thickness was also increased in caudal regions. The expression domain and levels of Fgf8, as well as overall patterning, were unchanged. In contrast, the changes in caudolateral surface area were associated with accelerated cell cycle in early stages of neurogenesis without an alteration of cell cycle exit. Moreover, a marked overproduction of intermediate neuronal progenitors was observed in later stages, indicating prolongation of neurogenesis. Conclusion Activation of Fgfr3 selectively promotes growth of caudolateral (occipitotemporal) cortex. These observations support the 'radial unit' and 'radial amplification' hypotheses and may explain premature sulcation of the occipitotemporal cortex in thanatophoric dysplasia, a human FGFR3 disorder. Together with previous work, this study suggests that formation of rostral and caudal areas are differentially regulated by Fgf signaling in the cerebral cortex." @default.
• W2083740746 created "2016-06-24" @default.
• W2083740746 creator A5005350060 @default.
• W2083740746 creator A5012780397 @default.
• W2083740746 creator A5020643827 @default.
• W2083740746 creator A5030607028 @default.
• W2083740746 creator A5041026882 @default.
• W2083740746 creator A5053829922 @default.
• W2083740746 creator A5061127761 @default.
• W2083740746 creator A5079182695 @default.
• W2083740746 creator A5084280682 @default.
• W2083740746 date "2009-02-03" @default.
• W2083740746 modified "2023-10-18" @default.
• W2083740746 title "Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortex" @default.
• W2083740746 cites W1506357334 @default.
• W2083740746 cites W1570281893 @default.
• W2083740746 cites W1582081614 @default.
• W2083740746 cites W1608092431 @default.
• W2083740746 cites W1761323037 @default.
• W2083740746 cites W1970783808 @default.
• W2083740746 cites W1974374273 @default.
• W2083740746 cites W1974651731 @default.
• W2083740746 cites W1981267260 @default.
• W2083740746 cites W1981856729 @default.
• W2083740746 cites W1982662107 @default.
• W2083740746 cites W1988754143 @default.
• W2083740746 cites W1988976106 @default.
• W2083740746 cites W1989412277 @default.
• W2083740746 cites W1990935914 @default.
• W2083740746 cites W1992415431 @default.
• W2083740746 cites W1992682918 @default.
• W2083740746 cites W1999970417 @default.
• W2083740746 cites W2004075797 @default.
• W2083740746 cites W2012470399 @default.
• W2083740746 cites W2015282923 @default.
• W2083740746 cites W2015313975 @default.
• W2083740746 cites W2016997675 @default.
• W2083740746 cites W2022274052 @default.
• W2083740746 cites W2032455771 @default.
• W2083740746 cites W2034119300 @default.
• W2083740746 cites W2037004283 @default.
• W2083740746 cites W2047727235 @default.
• W2083740746 cites W2049107929 @default.
• W2083740746 cites W2055172928 @default.
• W2083740746 cites W2056304112 @default.
• W2083740746 cites W2062231851 @default.
• W2083740746 cites W2066699807 @default.
• W2083740746 cites W2066971174 @default.
• W2083740746 cites W2070729834 @default.
• W2083740746 cites W2072303535 @default.
• W2083740746 cites W2072673889 @default.
• W2083740746 cites W2078950435 @default.
• W2083740746 cites W2093712120 @default.
• W2083740746 cites W2102793585 @default.
• W2083740746 cites W2105671340 @default.
• W2083740746 cites W2110387447 @default.
• W2083740746 cites W2112074923 @default.
• W2083740746 cites W2112809461 @default.
• W2083740746 cites W2119402894 @default.
• W2083740746 cites W2120761216 @default.
• W2083740746 cites W2121266463 @default.
• W2083740746 cites W2130793535 @default.
• W2083740746 cites W2131483842 @default.
• W2083740746 cites W2141759106 @default.
• W2083740746 cites W2147094077 @default.
• W2083740746 cites W2153347923 @default.
• W2083740746 cites W2156221138 @default.
• W2083740746 cites W2157001435 @default.
• W2083740746 cites W2163961175 @default.
• W2083740746 cites W2165132176 @default.
• W2083740746 cites W2168785085 @default.
• W2083740746 cites W2172202356 @default.
• W2083740746 cites W4211075026 @default.
• W2083740746 cites W608227570 @default.
• W2083740746 doi "https://doi.org/10.1186/1749-8104-4-4" @default.
• W2083740746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2661882" @default.
• W2083740746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19192266" @default.
• W2083740746 hasPublicationYear "2009" @default.
• W2083740746 type Work @default.
• W2083740746 sameAs 2083740746 @default.
• W2083740746 citedByCount "56" @default.
• W2083740746 countsByYear W20837407462012 @default.
• W2083740746 countsByYear W20837407462013 @default.
• W2083740746 countsByYear W20837407462014 @default.
• W2083740746 countsByYear W20837407462015 @default.
• W2083740746 countsByYear W20837407462016 @default.
• W2083740746 countsByYear W20837407462017 @default.
• W2083740746 countsByYear W20837407462018 @default.
• W2083740746 countsByYear W20837407462019 @default.
• W2083740746 countsByYear W20837407462020 @default.
• W2083740746 countsByYear W20837407462022 @default.
• W2083740746 countsByYear W20837407462023 @default.
• W2083740746 crossrefType "journal-article" @default.
• W2083740746 hasAuthorship W2083740746A5005350060 @default.
• W2083740746 hasAuthorship W2083740746A5012780397 @default.
• W2083740746 hasAuthorship W2083740746A5020643827 @default.
• W2083740746 hasAuthorship W2083740746A5030607028 @default.
• W2083740746 hasAuthorship W2083740746A5041026882 @default.
• W2083740746 hasAuthorship W2083740746A5053829922 @default.
• W2083740746 hasAuthorship W2083740746A5061127761 @default.

• next